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Gene · 51673

TPPP3: tubulin polymerization promoting protein family member 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TPPP3: tubulin polymerization promoting protein family member 3. Genes, record 51673. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51673

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Gene

Symbol
TPPP3
HGNC
Name
tubulin polymerization promoting protein family member 3
HGNC
NCBI Gene ID
51673
NCBI Gene
HGNC ID
HGNC:24162
HGNC
Ensembl
ENSG00000159713
NCBI Gene
Aliases
CGI-38, TPPP/p20, p20, p25gamma
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9BW30Tubulin polymerization-promoting protein family member 31761Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 11860162 B22024-01-021109Q9BW30Espacenet
US 11564998 B22023-01-315124Q9BW30Espacenet
US 11564998 B22023-01-316838Q9BW30Espacenet
US 11446398 B22022-09-2093448Q9BW30Espacenet
US 11446398 B22022-09-2093449Q9BW30Espacenet
US 11446398 B22022-09-2093450Q9BW30Espacenet
US 11446398 B22022-09-2093451Q9BW30Espacenet
JP 2022524081 A2022-04-27196419Q9BW30Espacenet
JP 2022524081 A2022-04-27196420Q9BW30Espacenet
JP 2022524081 A2022-04-27196421Q9BW30Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,177

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTPPP3 papersNewest fiscal year
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation72025
P30CA008748Cancer Center Support Grant62025
R01AI124346Innate immune signaling and stress response62025
R01HL136389The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis62025
P30DK034854Integrated Epithelial and Muscosal Biology52025
R01AI124491NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing52025
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation52025
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition52025
P30CA021765Cancer Center Support Grant (CCSG)42025
K12GM081259IRACDA at the University of Pennsylvania: Penn Postdoctoral Opportunities in Research and Teaching (PennPORT).32025

1 to 10 of 1,177Source NIH's project files

See all 1,177 nih grants

Papers1,850

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Lithium-associated peripheral transcriptional signatures correlate with brain white matter microstructure in bipolar disorder.Int Clin Psychopharmacol202642742966PubTator, text miningPubMed
TPPP3 Overexpression Suppresses Nasopharyngeal Carcinoma Progression and Promotes Immune Microenvironment Remodeling Through HSPA8 Association.Cancers (Basel)202642738372PubTator, text miningPubMed
Particulate Matter Exposure and Diabetic Kidney Dysfunction: Insights from Integrated Transcriptomic and Bioinformatics Analyses.Int J Mol Sci202642737513PubTator, text miningPubMed
Proteomic signatures of protected APOE ε4 carriers reveal causal pathways associated with delayed Alzheimer's disease onset.Alzheimers Dement202642592812PubTator, text miningPubMed
Synthesis, structure and properties of Pt(II) α-pyrrolyl dipyrrin complexes that exhibit anticancer activities.Dalton Trans202642573421PubTator, text miningPubMed
Retraction notice to "Molecular structure and mechanism of protein MSMB, TPPP3, SPI1: Construction of novel 4 pancreatic cancer-related protein signatures model based on machine learning" [Int. J. Biol. Macromol. 307 (2025) 142075].
Int J Biol Macromol202642527178PubTator, text miningPubMed
Cryo-EM structures of human caspase-4 in complex with full-length gasdermin D.Structure202642442362PubTator, text miningPubMed
ROS-TXNIP-NLRP3 inflammasome axis-driven macrophage activation contributes to endothelial dysfunction in Kawasaki disease.Tissue Cell202642263501PubTator, text miningPubMed
Cisplatin resistance in an ovarian cancer model is mediated by microtubule dynamics regulator TPPP3 in synergy with tubulin code rewiring.Cell Rep202642241284PubTator, text miningPubMed
Skin Application of Inflammasome Inhibitor MCC950 Prevents Psoriasis-like Cutaneous Manifestations and Associated Systemic Inflammation.Inflammation202642240911PubTator, text miningPubMed

1 to 10 of 1,850

See all 1,850 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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