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Gene · 5169

ENPP3: ectonucleotide pyrophosphatase/phosphodiesterase 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ENPP3: ectonucleotide pyrophosphatase/phosphodiesterase 3. Genes, record 5169. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5169

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Gene

Symbol
ENPP3
HGNC
Name
ectonucleotide pyrophosphatase/phosphodiesterase 3
HGNC
NCBI Gene ID
5169
NCBI Gene
HGNC ID
HGNC:3358
HGNC
Ensembl
ENSG00000154269
NCBI Gene
Aliases
B10, CD203c, NPP3, PD-IBETA, PDNP3, gp130RB13-6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14638Ectonucleotide pyrophosphatase/phosphodiesterase family member 38753Ensembl, GeneID, HGNC

Source UniProt

Patents114

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004432 A2026-01-1448O14638Espacenet
JP 2026004568 A2026-01-1444724O14638Espacenet
JP 2026004568 A2026-01-1444726O14638Espacenet
US 12514926 B22026-01-0648O14638Espacenet
EP 4640849 A22025-10-291110O14638Espacenet
EP 4641201 A22025-10-297431O14638Espacenet
JP 2025519096 A2025-06-241110O14638Espacenet
WO 2025126102 A12025-06-1951O14638Espacenet
JP 2025517969 A2025-06-127431O14638Espacenet
JP 2025517332 A2025-06-05131O14638Espacenet

1 to 10 of 114

See all 114 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
AGS-16C3FCHEMBL4594455Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 binding agentBINDING AGENT

Source ChEMBL

Trials2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02639182AGS-16C3FPHASE22020-09-23ClinicalTrials.gov
NCT01672775AGS-16C3FPHASE1ClinicalTrials.gov

NIH grants1,181

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleENPP3 papersNewest fiscal year
U19AI104209Integrated Genomic and Functional Studies of Immunotherapy for Multi-Food Allergy122025
T32AI007062Research Training in Allergy and Clinical Immunology82025
P30CA016086Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant62025
P30ES010126UNC Center for Environmental Health and Susceptibility62025
ZIAAI000249The Pathogenesis, Diagnosis, and Treatment of Systemic Mast Cell Disorders62025
R01AG044335Goals and Motivation to Remember Important Information in Old Age52025
P30CA077598Cancer Center Support Grant42025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)42025
P01HL136275Immune Cell Interactions in Atherosclerosis32025

1 to 10 of 1,181Source NIH's project files

See all 1,181 nih grants

Papers2,209

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Assessment of fluorescence interference in the basophil activation test: a case of indocyanine green-induced anaphylaxis.J Anesth202642802243PubTator, text miningPubMed
Development of potent and selective ENPP1 inhibitors based on imidazo[1,2-a]pyrazine and pyrazine scaffolds for cancer immunotherapy.Eur J Med Chem202642648057PubTator, text miningPubMed
The Basophil Activation Test in Allergy Diagnostics: Clinical Applications, Methodological Challenges, and Proposed Clinical Frameworks.Cells202642505351PubTator, text miningPubMed
Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test.Allergy202642493353PubTator, text miningPubMed
Case Report: aleukemic mast cell leukemia with KIT p.V559G mutation, CD25-negative immunophenotype, and complex karyotype.Front Oncol202642488121PubTator, text miningPubMed
ENPP3 CAR T cells combined with CD206 modulation suppress adrenocortical carcinoma.J Immunother Cancer202642386343PubTator, text miningPubMed
Anaphylaxis during hemodialysis associated with a polysulfone membrane: evidence from basophil activation testing.Kidney Res Clin Pract202642299450PubTator, text miningPubMed
Identification of common genes associated with diabetic nephropathy and diabetic retinopathy.Front Cell Dev Biol202642131108PubTator, text miningPubMed
Efficacy predictions for omalizumab treatment based on basophil CD203c expression in patients with allergic rhinitis by basophil activation test -- a real-life, pilot study.World Allergy Organ J202642058162PubTator, text miningPubMed
Utility of basophil activation tests in the diagnosis of cross-intolerance to nonsteroidal anti-inflammatory drug reactions.Allergy Asthma Proc202642050829PubTator, text miningPubMed

1 to 10 of 2,209

See all 2,209 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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