Gene · 5169
ENPP3: ectonucleotide pyrophosphatase/phosphodiesterase 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ENPP3: ectonucleotide pyrophosphatase/phosphodiesterase 3. Genes, record 5169. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5169
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14638 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 | 875 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents114
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004432 A | 2026-01-14 | 48 | O14638 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 44724 | O14638 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 44726 | O14638 | Espacenet |
| US 12514926 B2 | 2026-01-06 | 48 | O14638 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1110 | O14638 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7431 | O14638 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1110 | O14638 | Espacenet |
| WO 2025126102 A1 | 2025-06-19 | 51 | O14638 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7431 | O14638 | Espacenet |
| JP 2025517332 A | 2025-06-05 | 131 | O14638 | Espacenet |
1 to 10 of 114
See all 114 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| AGS-16C3F | CHEMBL4594455 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 binding agent | BINDING AGENT |
Source ChEMBL
Trials2
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02639182 | AGS-16C3F | PHASE2 | 2020-09-23 | ClinicalTrials.gov |
| NCT01672775 | AGS-16C3F | PHASE1 | ClinicalTrials.gov |
NIH grants1,181
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ENPP3 papers | Newest fiscal year |
|---|---|---|---|
| U19AI104209 | Integrated Genomic and Functional Studies of Immunotherapy for Multi-Food Allergy | 12 | 2025 |
| T32AI007062 | Research Training in Allergy and Clinical Immunology | 8 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 6 | 2025 |
| ZIAAI000249 | The Pathogenesis, Diagnosis, and Treatment of Systemic Mast Cell Disorders | 6 | 2025 |
| R01AG044335 | Goals and Motivation to Remember Important Information in Old Age | 5 | 2025 |
| P30CA077598 | Cancer Center Support Grant | 4 | 2025 |
| P30DK040561 | Boston Area Nutrition Obesity Research Center (NORC) | 4 | 2025 |
| P01HL136275 | Immune Cell Interactions in Atherosclerosis | 3 | 2025 |
1 to 10 of 1,181Source NIH's project files
See all 1,181 nih grantsPapers2,209
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Assessment of fluorescence interference in the basophil activation test: a case of indocyanine green-induced anaphylaxis. | J Anesth | 2026 | 42802243 | PubTator, text mining | PubMed |
| Development of potent and selective ENPP1 inhibitors based on imidazo[1,2-a]pyrazine and pyrazine scaffolds for cancer immunotherapy. | Eur J Med Chem | 2026 | 42648057 | PubTator, text mining | PubMed |
| The Basophil Activation Test in Allergy Diagnostics: Clinical Applications, Methodological Challenges, and Proposed Clinical Frameworks. | Cells | 2026 | 42505351 | PubTator, text mining | PubMed |
| Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test. | Allergy | 2026 | 42493353 | PubTator, text mining | PubMed |
| Case Report: aleukemic mast cell leukemia with KIT p.V559G mutation, CD25-negative immunophenotype, and complex karyotype. | Front Oncol | 2026 | 42488121 | PubTator, text mining | PubMed |
| ENPP3 CAR T cells combined with CD206 modulation suppress adrenocortical carcinoma. | J Immunother Cancer | 2026 | 42386343 | PubTator, text mining | PubMed |
| Anaphylaxis during hemodialysis associated with a polysulfone membrane: evidence from basophil activation testing. | Kidney Res Clin Pract | 2026 | 42299450 | PubTator, text mining | PubMed |
| Identification of common genes associated with diabetic nephropathy and diabetic retinopathy. | Front Cell Dev Biol | 2026 | 42131108 | PubTator, text mining | PubMed |
| Efficacy predictions for omalizumab treatment based on basophil CD203c expression in patients with allergic rhinitis by basophil activation test -- a real-life, pilot study. | World Allergy Organ J | 2026 | 42058162 | PubTator, text mining | PubMed |
| Utility of basophil activation tests in the diagnosis of cross-intolerance to nonsteroidal anti-inflammatory drug reactions. | Allergy Asthma Proc | 2026 | 42050829 | PubTator, text mining | PubMed |
1 to 10 of 2,209
See all 2,209 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5169
GET https://conductscience.org/api/genes/v1/5169/patents?page=2