Gene · 5170
PDPK1: 3-phosphoinositide dependent protein kinase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PDPK1: 3-phosphoinositide dependent protein kinase 1. Genes, record 5170. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5170
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | 556 | 70 | Ensembl, GeneID, HGNC |
Source UniProt
Patents58
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 6874 | O15530 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6874 | O15530 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 306 | O15530 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 4711 | O15530 | Espacenet |
| US 11892452 B2 | 2024-02-06 | 97 | O15530 | Espacenet |
| US 11708396 B2 | 2023-07-25 | 1837 | O15530 | Espacenet |
| US 11696924 B2 | 2023-07-11 | 23 | O15530 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 306 | O15530 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 103277 | O15530 | Espacenet |
| US 11016093 B2 | 2021-05-25 | 97 | O15530 | Espacenet |
1 to 10 of 58
See all 58 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials16
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT00978523 | AR-12 | PHASE1 | ClinicalTrials.gov | |
| NCT00301938 | UCN-01 | PHASE1 | ClinicalTrials.gov | |
| NCT00098956 | UCN-01 | PHASE2 | 2015-09-09 | ClinicalTrials.gov |
| NCT00082017 | UCN-01 | PHASE2 | 2012-08-29 | ClinicalTrials.gov |
| NCT00072267 | UCN-01 | PHASE2 | ClinicalTrials.gov | |
| NCT00072189 | UCN-01 | PHASE2 | 2015-03-02 | ClinicalTrials.gov |
| NCT00045747 | UCN-01 | PHASE2 | ClinicalTrials.gov | |
| NCT00045513 | UCN-01 | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT00045500 | UCN-01 | PHASE1 | ClinicalTrials.gov | |
| NCT00045175 | UCN-01 | PHASE1 | ClinicalTrials.gov |
1 to 10 of 16
See all 16 trialsNIH grants1,622
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PDPK1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 20 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| ZIABC005708 | Xenobiotic metabolism, cancer chemoprevention and cancer biomarkers | 10 | 2025 |
| ZIABC005562 | Xenobiotic receptors | 7 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 6 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 5 | 2025 |
| R01CA200709 | Facilitated recruitment of MYC to chromatin by interaction with WDR5 | 4 | 2025 |
| P30CA016042 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,622Source NIH's project files
See all 1,622 nih grantsPapers2,673
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation. | Mol Oncol | 2026 | 42808303 | PubTator, text mining | PubMed |
| A De Novo 16p13.3 Triplication Underlying Early-Onset Complex Neurodegeneration. | Mov Disord | 2026 | 42734088 | PubTator, text mining | PubMed |
| PDK1 signaling in cancer: Current status and future perspectives. | Int J Biol Macromol | 2026 | 42716156 | PubTator, text mining | PubMed |
| Osthole and matrine suppress malignant progression of lead-exposed NSCLC via regulating cellular homeostasis: A combined network pharmacology and in vitro experimental study. | Phytomedicine | 2026 | 42555991 | PubTator, text mining | PubMed |
| The PDPK1-RSK2 axis as a potential convergent therapeutic vulnerability in B-cell lymphomas. | Expert Opin Ther Targets | 2026 | 42489440 | PubTator, text mining | PubMed |
| Akt inhibitor-IV in estrogen receptor-positive breast cancer cells: cytotoxic, apoptotic, transcriptional, and in-silico comparison with tamoxifen. | Anticancer Drugs | 2026 | 42390376 | PubTator, text mining | PubMed |
| Correction: Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs. | Cell Death Dis | 2026 | 42259783 | PubTator, text mining | PubMed |
| Penfluridol directly targets PDPK1 to suppress AKT1 phosphorylation and stabilize CTR1, inducing cuproptosis in colorectal cancer. | Acta Pharmacol Sin | 2026 | 42185682 | PubTator, text mining | PubMed |
| Thr308-dephosphorylated AKT1 licenses SQSTM1-LC3C-mediated antiviral autophagy. | Autophagy | 2026 | 42152503 | PubTator, text mining | PubMed |
| Genomic profile of an IDH-wild-type glioblastoma diagnosed following TNF-α inhibitor therapy: a molecular case study. | Front Oncol | 2026 | 42130630 | PubTator, text mining | PubMed |
1 to 10 of 2,673
See all 2,673 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5170
GET https://conductscience.org/api/genes/v1/5170/patents?page=2