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Gene · 51741

WWOX: WW domain containing oxidoreductase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. WWOX: WW domain containing oxidoreductase. Genes, record 51741. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51741

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Gene

Symbol
WWOX
HGNC
Name
WW domain containing oxidoreductase
HGNC
NCBI Gene ID
51741
NCBI Gene
HGNC ID
HGNC:12799
HGNC
Ensembl
ENSG00000186153
NCBI Gene
Aliases
D16S432E, DEE28, EIEE28, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NZC7WW domain-containing oxidoreductase4141Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1917213Q9NZC7Espacenet
EP 4641201 A22025-10-2921246Q9NZC7Espacenet
EP 4582143 A22025-07-092Q9NZC7Espacenet
JP 2025517969 A2025-06-1221246Q9NZC7Espacenet
JP 2025517970 A2025-06-1217213Q9NZC7Espacenet
JP 2024123008 A2024-09-109095Q9NZC7Espacenet
JP 2024123008 A2024-09-109097Q9NZC7Espacenet
JP 2023537093 A2023-08-305Q9NZC7Espacenet
KR 1020230051223 A2023-04-172Q9NZC7Espacenet
US 11446398 B22022-09-2097928Q9NZC7Espacenet

1 to 10 of 38

See all 38 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,483

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleWWOX papersNewest fiscal year
P30CA016672Cancer Center Support Grant232025
P30CA008748Cancer Center Support Grant112025
P30CA016058Cancer Center Support Grant112025
P30CA015704Cancer Center Support Grant72025
P30DK063491Diabetes Research Center (DRC)72025
P30CA056036Translational Research in Cancer62025
P30CA068485Cancer Center Support Grant52025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)42025
P30CA016086Cancer Center Support Grant42025
R01CA140657Modeling Neoplastic Progression in Barrett's Esophagus - Renewal -242025

1 to 10 of 1,483Source NIH's project files

See all 1,483 nih grants

Papers1,875

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
GWAS integrating maternal and child genetics reveals novel risk-modifying loci for fetal alcohol spectrum disorders (FASD).Res Sq202642818975PubTator, text miningPubMed
WWOX Suppresses Gastric Cancer Cell Proliferation, Migration, and EMT by Negatively Regulating the Wnt/β-Catenin Signaling Pathway.Ann Clin Lab Sci202642790938PubTator, text miningPubMed
WWOX-related developmental and epileptic encephalopathy (WOREE): A case series of seven patients from Argentina.Seizure202642721537PubTator, text miningPubMed
WWOX/HIF1A Balance Delineates Context-Dependent Molecular States in Breast Cancer Subtypes and Ovarian Carcinoma.Int J Mol Sci202642589397PubTator, text miningPubMed
Golgi CATCHR complexes function as organizing hubs for vesicle tethering and fusion.bioRxiv202642523332PubTator, text miningPubMed
The control of prickle formation in Rubus.Plant Physiol202642508810PubTator, text miningPubMed
[Retracted] p73 participates in WWOX-mediated apoptosis in leukemia cells.Int J Mol Med202642464650PubTator, text miningPubMed
Neuron-specific WWOX gene therapy produces dose-dependent, durable rescue in a model of WWOX-related epileptic encephalopathy.Mol Ther Adv202642422765PubTator, text miningPubMed
Disrupted WWOX-MYC interplay impairs neurogenesis in human brain organoids.Brain202642397075PubTator, text miningPubMed
WWOX contributes to DNA damage, but not somatic instability in Huntington's disease.bioRxiv202642395553PubTator, text miningPubMed

1 to 10 of 1,875

See all 1,875 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/51741

GET https://conductscience.org/api/genes/v1/51741/patents?page=2