Gene · 51752
ERAP1: endoplasmic reticulum aminopeptidase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ERAP1: endoplasmic reticulum aminopeptidase 1. Genes, record 51752. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51752
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NZ08 | Endoplasmic reticulum aminopeptidase 1 | 941 | 27 | Ensembl, GeneID, HGNC |
Source UniProt
Patents44
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 44936 | Q9NZ08 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 44937 | Q9NZ08 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 13399 | Q9NZ08 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 2333 | Q9NZ08 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 15280 | Q9NZ08 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 4858 | Q9NZ08 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6287 | Q9NZ08 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6287 | Q9NZ08 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 2333 | Q9NZ08 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 15280 | Q9NZ08 | Espacenet |
1 to 10 of 44
See all 44 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| TOSEDOSTAT | CHEMBL2103847 | Aminopeptidase inhibitor | INHIBITOR |
Source ChEMBL
Trials9
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02452346 | TOSEDOSTAT | PHASE2 | 2018-06-12 | ClinicalTrials.gov |
| NCT02352831 | TOSEDOSTAT | PHASE1/PHASE2 | 2018-12-17 | ClinicalTrials.gov |
| NCT01636609 | TOSEDOSTAT | PHASE1 | ClinicalTrials.gov | |
| NCT01567059 | TOSEDOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT01180426 | TOSEDOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT00780598 | TOSEDOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT00737555 | TOSEDOSTAT | PHASE1 | ClinicalTrials.gov | |
| NCT00689000 | TOSEDOSTAT | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT00522938 | TOSEDOSTAT | PHASE1/PHASE2 | ClinicalTrials.gov |
NIH grants1,029
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ERAP1 papers | Newest fiscal year |
|---|---|---|---|
| ZIAAR041184 | Pathogenic Mechanisms in Spondyloarthritis | 11 | 2025 |
| ZIDAR041180 | Clinical Support Services for the NIAMS Intramural Research Program | 8 | 2025 |
| R01AI044115 | Influences of HLA Class I Polymorphisms on immune responses | 6 | 2025 |
| ZIAAR041198 | Genetics and pathophysiology of systemic juvenile idiopathic arthritis and other complex autoinflammatory diseases | 5 | 2025 |
| P30AI110527 | Tennessee Center for AIDS Research (TN-CFAR) | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| R01AI114495 | Role of Tspan5 in MHC I antigen presentation and cancer immune evasion | 4 | 2025 |
| U01AI154659 | NATIENS: A Phase III Randomized Double Blinded Study to Determine the Mechanisms and Optimal Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 3 | 2025 |
1 to 10 of 1,029Source NIH's project files
See all 1,029 nih grantsPapers1,796
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Association of ERAP1 and IL23R Gene Polymorphisms with Susceptibility and Clinical Manifestations of Spondyloarthritis in Tunisian Patients. | Curr Rheumatol Rev | 2026 | 42768844 | PubTator, text mining | PubMed |
| Cancers modulate processing and presentation of p53 neoantigens to evade T cell detection. | Immunity | 2026 | 42753739 | PubTator, text mining | PubMed |
| Moonlighting ERAP Aminopeptidases in Cancer: Beyond Antigen Processing. | Cells | 2026 | 42738902 | PubTator, text mining | PubMed |
| From inflammation to rupture: advances in the pathogenesis of pseudoaneurysm formation in Vascular Behçet's Disease. | Front Immunol | 2026 | 42694747 | PubTator, text mining | PubMed |
| Exploring the Involvement of ERAP1 in the Pathogenesis of Non-Infectious Uveitis: A Systematic Review. | Life (Basel) | 2026 | 42653028 | PubTator, text mining | PubMed |
| Immunometabolic regulation and tissue-resident immunity in autoimmune uveitis: from genetic susceptibility to the gut-spleen-eye axis. | Inflamm Res | 2026 | 42608607 | PubTator, text mining | PubMed |
| Leveraging expression quantitative trait loci information in single-cell resolution to identify cell-specific genes for gestational diabetes. | PLoS One | 2026 | 42531322 | PubTator, text mining | PubMed |
| An integrated immunogenetic network architecture linking antigen processing and innate immune activation in Ankylosing Spondylitis. | Hum Immunol | 2026 | 42269371 | PubTator, text mining | PubMed |
| Combos New and Old Counter PD-(L)1 Resistance, Treat Rare Cancers. | Cancer Discov | 2026 | 42240229 | PubTator, text mining | PubMed |
| Integrated Host Genetics and Skin Microbiome Profiling Suggest an HLA-C-Peptostreptococcus Axis in Psoriasis. | Int J Mol Sci | 2026 | 42123693 | PubTator, text mining | PubMed |
1 to 10 of 1,796
See all 1,796 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/51752
GET https://conductscience.org/api/genes/v1/51752/patents?page=2