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Gene · 51752

ERAP1: endoplasmic reticulum aminopeptidase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ERAP1: endoplasmic reticulum aminopeptidase 1. Genes, record 51752. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51752

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Gene

Symbol
ERAP1
HGNC
Name
endoplasmic reticulum aminopeptidase 1
HGNC
NCBI Gene ID
51752
NCBI Gene
HGNC ID
HGNC:18173
HGNC
Ensembl
ENSG00000164307
NCBI Gene
Aliases
A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, KIAA0525, PILS-AP, PILSAP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NZ08Endoplasmic reticulum aminopeptidase 194127Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444936Q9NZ08Espacenet
JP 2026004568 A2026-01-1444937Q9NZ08Espacenet
EP 4650780 A22025-11-1913399Q9NZ08Espacenet
EP 4640849 A22025-10-292333Q9NZ08Espacenet
EP 4641201 A22025-10-2915280Q9NZ08Espacenet
JP 2025147176 A2025-10-064858Q9NZ08Espacenet
JP 2025529142 A2025-09-046287Q9NZ08Espacenet
US 12371689 B22025-07-296287Q9NZ08Espacenet
JP 2025519096 A2025-06-242333Q9NZ08Espacenet
JP 2025517969 A2025-06-1215280Q9NZ08Espacenet

1 to 10 of 44

See all 44 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
TOSEDOSTATCHEMBL2103847Aminopeptidase inhibitorINHIBITOR

Source ChEMBL

Trials9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02452346TOSEDOSTATPHASE22018-06-12ClinicalTrials.gov
NCT02352831TOSEDOSTATPHASE1/PHASE22018-12-17ClinicalTrials.gov
NCT01636609TOSEDOSTATPHASE1ClinicalTrials.gov
NCT01567059TOSEDOSTATPHASE2ClinicalTrials.gov
NCT01180426TOSEDOSTATPHASE2ClinicalTrials.gov
NCT00780598TOSEDOSTATPHASE2ClinicalTrials.gov
NCT00737555TOSEDOSTATPHASE1ClinicalTrials.gov
NCT00689000TOSEDOSTATPHASE1/PHASE2ClinicalTrials.gov
NCT00522938TOSEDOSTATPHASE1/PHASE2ClinicalTrials.gov

NIH grants1,029

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleERAP1 papersNewest fiscal year
ZIAAR041184Pathogenic Mechanisms in Spondyloarthritis112025
ZIDAR041180Clinical Support Services for the NIAMS Intramural Research Program82025
R01AI044115Influences of HLA Class I Polymorphisms on immune responses62025
ZIAAR041198Genetics and pathophysiology of systemic juvenile idiopathic arthritis and other complex autoinflammatory diseases52025
P30AI110527Tennessee Center for AIDS Research (TN-CFAR)42025
P30CA008748Cancer Center Support Grant42025
R01AI114495Role of Tspan5 in MHC I antigen presentation and cancer immune evasion42025
U01AI154659NATIENS: A Phase III Randomized Double Blinded Study to Determine the Mechanisms and Optimal Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis42025
P30CA016672Cancer Center Support Grant32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025

1 to 10 of 1,029Source NIH's project files

See all 1,029 nih grants

Papers1,796

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Association of ERAP1 and IL23R Gene Polymorphisms with Susceptibility and Clinical Manifestations of Spondyloarthritis in Tunisian Patients.Curr Rheumatol Rev202642768844PubTator, text miningPubMed
Cancers modulate processing and presentation of p53 neoantigens to evade T cell detection.Immunity202642753739PubTator, text miningPubMed
Moonlighting ERAP Aminopeptidases in Cancer: Beyond Antigen Processing.Cells202642738902PubTator, text miningPubMed
From inflammation to rupture: advances in the pathogenesis of pseudoaneurysm formation in Vascular Behçet's Disease.Front Immunol202642694747PubTator, text miningPubMed
Exploring the Involvement of ERAP1 in the Pathogenesis of Non-Infectious Uveitis: A Systematic Review.Life (Basel)202642653028PubTator, text miningPubMed
Immunometabolic regulation and tissue-resident immunity in autoimmune uveitis: from genetic susceptibility to the gut-spleen-eye axis.Inflamm Res202642608607PubTator, text miningPubMed
Leveraging expression quantitative trait loci information in single-cell resolution to identify cell-specific genes for gestational diabetes.PLoS One202642531322PubTator, text miningPubMed
An integrated immunogenetic network architecture linking antigen processing and innate immune activation in Ankylosing Spondylitis.Hum Immunol202642269371PubTator, text miningPubMed
Combos New and Old Counter PD-(L)1 Resistance, Treat Rare Cancers.Cancer Discov202642240229PubTator, text miningPubMed
Integrated Host Genetics and Skin Microbiome Profiling Suggest an HLA-C-Peptostreptococcus Axis in Psoriasis.Int J Mol Sci202642123693PubTator, text miningPubMed

1 to 10 of 1,796

See all 1,796 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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GET https://conductscience.org/api/genes/v1/51752/patents?page=2