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Gene · 51755

CDK12: cyclin dependent kinase 12

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CDK12: cyclin dependent kinase 12. Genes, record 51755. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51755

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Gene

Symbol
CDK12
HGNC
Name
cyclin dependent kinase 12
HGNC
NCBI Gene ID
51755
NCBI Gene
HGNC ID
HGNC:24224
HGNC
Ensembl
ENSG00000167258
NCBI Gene
Aliases
CRK7, CRKR, CRKRS, KIAA0904
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NYV4Cyclin-dependent kinase 121,49039Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US RE050776 E12026-02-03275Q9NYV4Espacenet
EP 4650780 A22025-11-1912941Q9NYV4Espacenet
EP 4641201 A22025-10-2914505Q9NYV4Espacenet
JP 2025517969 A2025-06-1214505Q9NYV4Espacenet
JP 2025517970 A2025-06-1212941Q9NYV4Espacenet
US 12098154 B22024-09-24275Q9NYV4Espacenet
US 12037646 B22024-07-165Q9NYV4Espacenet
US 11976334 B22024-05-07130Q9NYV4Espacenet
US 11932625 B22024-03-192Q9NYV4Espacenet
JP 2023052006 A2023-04-11275Q9NYV4Espacenet

1 to 10 of 44

See all 44 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AT-7519CHEMBL445813Cyclin-dependent kinase inhibitorINHIBITORChEMBL
AZD-5438CHEMBL488436Cyclin-dependent kinase inhibitorINHIBITORChEMBL
PHA-793887CHEMBL1230607Cyclin-dependent kinase inhibitorINHIBITORChEMBL
RONICICLIBCHEMBL4442620Cyclin-dependent kinase inhibitorINHIBITORChEMBL

Trials7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02522910RONICICLIBPHASE1/PHASE2ClinicalTrials.gov
NCT02161419RONICICLIBPHASE2ClinicalTrials.gov
NCT01652144AT-7519PHASE2ClinicalTrials.gov
NCT01627054AT-7519PHASE2ClinicalTrials.gov
NCT01573338RONICICLIBPHASE1/PHASE2ClinicalTrials.gov
NCT01188252RONICICLIBPHASE1ClinicalTrials.gov
NCT01183949AT-7519PHASE1/PHASE2ClinicalTrials.gov

NIH grants2,235

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCDK12 papersNewest fiscal year
P30CA008748Cancer Center Support Grant682025
P30CA016672Cancer Center Support Grant342025
P30CA006973Regional Oncology Research Center262025
P50CA097186The Pacific Northwest Prostate Cancer SPORE252025
P30CA015704Cancer Center Support Grant242025
P50CA186786Michigan Prostate SPORE 2025-2030202025
P50CA092629SPORE in Prostate Cancer122025
P30CA076292Moffitt Cancer Center Support Grant112025
P30CA086862Cancer Center Support Grant112025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028102025

1 to 10 of 2,235Source NIH's project files

See all 2,235 nih grants

Papers3,441

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CDK7, CDK9, or CDK11 inhibition reduces neutrophil-driven inflammation and tissue damage in experimental autoimmune models.Cell Commun Signal202642823736PubTator, text miningPubMed
Bacopa monnieri attenuates Alzheimer's pathology by modulating RNA metabolism, cellular stress responses, and Rho GTPase signaling: Phosphoproteomic insights from a cellular model of Alzheimer's disease.
Neurochem Int202642810623PubTator, text miningPubMed
Androgen Receptor-Immune Crosstalk in Metastatic Castration-Resistant Prostate Cancer: From Context-Dependent Remodeling to Biomarker-Guided Translation.Prostate202642801730PubTator, text miningPubMed
Protein Expression Dynamics in Breast Cancer Cells Exposed to Nano-Encapsulated Tarin, the Taro Lectin.Pharmaceutics202642797298PubTator, text miningPubMed
Association of ATM Alterations with Outcomes After 177Lu-PSMA-617 Treatment in Patients with Metastatic Castration-Resistant Prostate Cancer.J Nucl Med202642785951PubTator, text miningPubMed
DNA damage repair gene defects combined predict the efficacy of immune checkpoint inhibitors in metastatic castration-resistant prostate cancer: a retrospective cohort study.Front Genet202642741774PubTator, text miningPubMed
Comprehensive Clinicopathologic, Immunohistochemical, and Genomic Profiling of Sporadic Ampullary Somatostatin-producing D-cell Neuroendocrine Tumors Identifies Recurrent HRAS Hotspot Mutations.Endocr Pathol202642730891PubTator, text miningPubMed
Genome-wide CRISPR screens map synthetic lethal interactions across recurrent cancer driver alterations.Cell Rep202642726641PubTator, text miningPubMed
Ellagic acid and bone health: a systematic review of preclinical studies on its protective role against osteoporosis.Mol Biol Rep202642700298PubTator, text miningPubMed
Cannabidiol alters the epigenome of hormone-dependent prostate cancer cells.Biomed Pharmacother202642691574PubTator, text miningPubMed

1 to 10 of 3,441

See all 3,441 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/51755

GET https://conductscience.org/api/genes/v1/51755/patents?page=2