Gene · 51755
CDK12: cyclin dependent kinase 12
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CDK12: cyclin dependent kinase 12. Genes, record 51755. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/51755
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NYV4 | Cyclin-dependent kinase 12 | 1,490 | 39 | Ensembl, GeneID, HGNC |
Source UniProt
Patents44
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US RE050776 E1 | 2026-02-03 | 275 | Q9NYV4 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 12941 | Q9NYV4 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 14505 | Q9NYV4 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 14505 | Q9NYV4 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 12941 | Q9NYV4 | Espacenet |
| US 12098154 B2 | 2024-09-24 | 275 | Q9NYV4 | Espacenet |
| US 12037646 B2 | 2024-07-16 | 5 | Q9NYV4 | Espacenet |
| US 11976334 B2 | 2024-05-07 | 130 | Q9NYV4 | Espacenet |
| US 11932625 B2 | 2024-03-19 | 2 | Q9NYV4 | Espacenet |
| JP 2023052006 A | 2023-04-11 | 275 | Q9NYV4 | Espacenet |
1 to 10 of 44
See all 44 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AT-7519 | CHEMBL445813 | Cyclin-dependent kinase inhibitor | INHIBITOR | ChEMBL |
| AZD-5438 | CHEMBL488436 | Cyclin-dependent kinase inhibitor | INHIBITOR | ChEMBL |
| PHA-793887 | CHEMBL1230607 | Cyclin-dependent kinase inhibitor | INHIBITOR | ChEMBL |
| RONICICLIB | CHEMBL4442620 | Cyclin-dependent kinase inhibitor | INHIBITOR | ChEMBL |
Trials7
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02522910 | RONICICLIB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT02161419 | RONICICLIB | PHASE2 | ClinicalTrials.gov | |
| NCT01652144 | AT-7519 | PHASE2 | ClinicalTrials.gov | |
| NCT01627054 | AT-7519 | PHASE2 | ClinicalTrials.gov | |
| NCT01573338 | RONICICLIB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT01188252 | RONICICLIB | PHASE1 | ClinicalTrials.gov | |
| NCT01183949 | AT-7519 | PHASE1/PHASE2 | ClinicalTrials.gov |
NIH grants2,235
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CDK12 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 68 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 34 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 26 | 2025 |
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 25 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 24 | 2025 |
| P50CA186786 | Michigan Prostate SPORE 2025-2030 | 20 | 2025 |
| P50CA092629 | SPORE in Prostate Cancer | 12 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 11 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 11 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 10 | 2025 |
1 to 10 of 2,235Source NIH's project files
See all 2,235 nih grantsPapers3,441
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| CDK7, CDK9, or CDK11 inhibition reduces neutrophil-driven inflammation and tissue damage in experimental autoimmune models. | Cell Commun Signal | 2026 | 42823736 | PubTator, text mining | PubMed |
Bacopa monnieri attenuates Alzheimer's pathology by modulating RNA metabolism, cellular stress responses, and Rho GTPase signaling: Phosphoproteomic insights from a cellular model of Alzheimer's disease. | Neurochem Int | 2026 | 42810623 | PubTator, text mining | PubMed |
| Androgen Receptor-Immune Crosstalk in Metastatic Castration-Resistant Prostate Cancer: From Context-Dependent Remodeling to Biomarker-Guided Translation. | Prostate | 2026 | 42801730 | PubTator, text mining | PubMed |
| Protein Expression Dynamics in Breast Cancer Cells Exposed to Nano-Encapsulated Tarin, the Taro Lectin. | Pharmaceutics | 2026 | 42797298 | PubTator, text mining | PubMed |
| Association of ATM Alterations with Outcomes After 177Lu-PSMA-617 Treatment in Patients with Metastatic Castration-Resistant Prostate Cancer. | J Nucl Med | 2026 | 42785951 | PubTator, text mining | PubMed |
| DNA damage repair gene defects combined predict the efficacy of immune checkpoint inhibitors in metastatic castration-resistant prostate cancer: a retrospective cohort study. | Front Genet | 2026 | 42741774 | PubTator, text mining | PubMed |
| Comprehensive Clinicopathologic, Immunohistochemical, and Genomic Profiling of Sporadic Ampullary Somatostatin-producing D-cell Neuroendocrine Tumors Identifies Recurrent HRAS Hotspot Mutations. | Endocr Pathol | 2026 | 42730891 | PubTator, text mining | PubMed |
| Genome-wide CRISPR screens map synthetic lethal interactions across recurrent cancer driver alterations. | Cell Rep | 2026 | 42726641 | PubTator, text mining | PubMed |
| Ellagic acid and bone health: a systematic review of preclinical studies on its protective role against osteoporosis. | Mol Biol Rep | 2026 | 42700298 | PubTator, text mining | PubMed |
| Cannabidiol alters the epigenome of hormone-dependent prostate cancer cells. | Biomed Pharmacother | 2026 | 42691574 | PubTator, text mining | PubMed |
1 to 10 of 3,441
See all 3,441 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/51755
GET https://conductscience.org/api/genes/v1/51755/patents?page=2