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Gene · 5179

PENK: proenkephalin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PENK: proenkephalin. Genes, record 5179. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5179

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Gene

Symbol
PENK
HGNC
Name
proenkephalin
HGNC
NCBI Gene ID
5179
NCBI Gene
HGNC ID
HGNC:8831
HGNC
Ensembl
ENSG00000181195
NCBI Gene
Aliases
PE, PENK-A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P01210Proenkephalin-A2679Ensembl, GeneID, HGNC

Source UniProt

Patents69

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459088P01210Espacenet
JP 2026004568 A2026-01-1459089P01210Espacenet
EP 4650780 A22025-11-195543P01210Espacenet
EP 4641201 A22025-10-295161P01210Espacenet
JP 2025147176 A2025-10-0610253P01210Espacenet
JP 2025147176 A2025-10-0610254P01210Espacenet
JP 2025529142 A2025-09-047322P01210Espacenet
US 12371689 B22025-07-297322P01210Espacenet
JP 2025517969 A2025-06-125161P01210Espacenet
JP 2025517970 A2025-06-125543P01210Espacenet

1 to 10 of 69

See all 69 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,516

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePENK papersNewest fiscal year
P30DA018310Neurometabolomics and Neuroproteomics Center on Cell-Cell Signaling72025
UL1TR001863Yale Clinical and Translational Science Award62025
P30CA008748Cancer Center Support Grant42025
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology42025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).42025
P30CA016672Cancer Center Support Grant32025
P30EY003039UAB Core Grant for Vision Research32025
P30EY008098Core Grant for Vision Research32025
R01DA008863Regulation Of Opioid Receptor Signaling by Endogenous Peptides32025
R28AA012725Brain Tissue Resource Center for Alcohol Research32025

1 to 10 of 1,516Source NIH's project files

See all 1,516 nih grants

Papers2,097

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Role of Proenkephalin in Predicting Renal Dysfunction and Mortality in Septic Patients Admitted to the Emergency Department and Intensive Care Unit: A Narrative Review.J Pers Med202642783482PubTator, text miningPubMed
Reference values for serum proenkephalin A in a pediatric and young adult cohort.Clin Biochem202642702244PubTator, text miningPubMed
Plasma proenkephalin-a facilitates measurement of human kidney functional reserve: From healthy kidney donors to polymorbid patients.Physiol Rep202642655869PubTator, text miningPubMed
Prenatal exposure to environmental stressors alters gut macrophage development and gastrointestinal function of male offspring.Brain Behav Immun202642575453PubTator, text miningPubMed
Proenkephalin A for assessing kidney integrity and guiding KRT liberation decisions in critically ill patients.Ann Intensive Care202642571343PubTator, text miningPubMed
Beyond Creatinine: Novel Renal Biomarkers at the Interface of Kidney Injury and Cardiovascular Risk.Biomedicines202642511998PubTator, text miningPubMed
Dynamics in kidney function markers as predictors of post-ICU survival: an innovative approach to enhance marker accuracy.Front Med (Lausanne)202642440654PubTator, text miningPubMed
A study on the prognosis of patients with sepsis or septic shock based on plasma proenkephalin levels: a meta-analysis.Biomarkers202642377086PubTator, text miningPubMed
A descending posterior insular pathway drives sensory hypersensitivity in neuropathic pain.Brain202642366792PubTator, text miningPubMed
Ultra-sensitive urine DNA methylation test enables early and accurate detection of bladder cancer.Epigenomics202642324902PubTator, text miningPubMed

1 to 10 of 2,097

See all 2,097 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5179

GET https://conductscience.org/api/genes/v1/5179/patents?page=2