Gene · 5187
PER1: period circadian regulator 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PER1: period circadian regulator 1. Genes, record 5187. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5187
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15534 | Period circadian protein homolog 1 | 1,290 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents28
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 4957 | O15534 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4533 | O15534 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4533 | O15534 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4957 | O15534 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 33284 | O15534 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 33284 | O15534 | Espacenet |
| US 11860162 B2 | 2024-01-02 | 1370 | O15534 | Espacenet |
| US 11708396 B2 | 2023-07-25 | 2445 | O15534 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 33284 | O15534 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 5389 | O15534 | Espacenet |
1 to 10 of 28
See all 28 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,275
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PER1 papers | Newest fiscal year |
|---|---|---|---|
| P30ES013508 | Center of Excellence in Environmental Toxicology | 9 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| R35GM118102 | Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock | 6 | 2025 |
| U54GM104942 | West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health | 6 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 5 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 5 | 2025 |
| R01AG039547 | Circadian Clock and Dietary Restriction | 5 | 2025 |
| T32HL007901 | Training in Sleep, Circadian, and Respiratory Neurobiology | 5 | 2025 |
1 to 10 of 2,275Source NIH's project files
See all 2,275 nih grantsPapers3,143
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Self-assembled micelles of Glycyrrhizic acid and Glabridin: A novel transdermal delivery system with enhanced whitening efficacy. | Int J Pharm | 2026 | 42822710 | PubTator, text mining | PubMed |
| Glucocorticoids Do Not Enhance BK Polyomavirus Replication in Human Renal Proximal Tubular Epithelial Cells In Vitro. | Clin Transl Sci | 2026 | 42817405 | PubTator, text mining | PubMed |
| Trimester-specific associations of methyl-donor nutrients and prenatal dietary patterns with adolescent blood leukocyte circadian gene DNA methylation. | J Dev Orig Health Dis | 2026 | 42788273 | PubTator, text mining | PubMed |
| Diurnal Insulin Clearance and Circadian Metabolic Gene Signatures in MASLD: Integrative Multi-Dataset Physiological and Transcriptomic Analysis. | Metabolites | 2026 | 42783754 | PubTator, text mining | PubMed |
| 11β-HSD2 buffers fetal glucocorticoid exposure inducing Per1 expression under maternal stress. | PNAS Nexus | 2026 | 42703617 | PubTator, text mining | PubMed |
| Molecular and clinicopathological insights into oral squamous cell carcinoma: Exploring oxidative stress, ferroptosis, circadian regulation, and novel biomarkers. | Cancer Treat Res Commun | 2026 | 42607534 | PubTator, text mining | PubMed |
| Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes. | Diabetology (Basel) | 2026 | 42583078 | PubTator, text mining | PubMed |
| PER1-related inflammatory signaling links night shift exposure to lower lung function in coal miners. | iScience | 2026 | 42541301 | PubTator, text mining | PubMed |
| Circadian Disruption as a Determinant of the Tumor Temporal State in Colorectal Cancer: A PRISMA-Based Systematic Review Integrating Metabolism, Immunity, and Metastasis. | Int J Mol Sci | 2026 | 42511510 | PubTator, text mining | PubMed |
| Gut Microbiota Modulation as a Therapeutic Strategy for Insomnia: A Systematic Review of Nutritional and Botanical Interventions. | Biomolecules | 2026 | 42509727 | PubTator, text mining | PubMed |
1 to 10 of 3,143
See all 3,143 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5187
GET https://conductscience.org/api/genes/v1/5187/patents?page=2