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Gene · 5187

PER1: period circadian regulator 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PER1: period circadian regulator 1. Genes, record 5187. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5187

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Gene

Symbol
PER1
HGNC
Name
period circadian regulator 1
HGNC
NCBI Gene ID
5187
NCBI Gene
HGNC ID
HGNC:8845
HGNC
Ensembl
ENSG00000179094
NCBI Gene
Aliases
PER, RIGUI, hPER
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15534Period circadian protein homolog 11,2900Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194957O15534Espacenet
EP 4641201 A22025-10-294533O15534Espacenet
JP 2025517969 A2025-06-124533O15534Espacenet
JP 2025517970 A2025-06-124957O15534Espacenet
JP 2025032204 A2025-03-1133284O15534Espacenet
EP 4461818 A22024-11-1333284O15534Espacenet
US 11860162 B22024-01-021370O15534Espacenet
US 11708396 B22023-07-252445O15534Espacenet
JP 2023058610 A2023-04-2533284O15534Espacenet
US 11564998 B22023-01-315389O15534Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,275

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePER1 papersNewest fiscal year
P30ES013508Center of Excellence in Environmental Toxicology92025
P30CA014195Cancer Center Support Grant (CCSG)62025
R35GM118102Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock62025
U54GM104942West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health62025
P30AG028740University of Florida Older Americans Independence Center (OAIC)52025
P30CA016056Roswell Park Cancer Center Support Grant52025
P30CA016672Cancer Center Support Grant52025
P30ES010126UNC Center for Environmental Health and Susceptibility52025
R01AG039547Circadian Clock and Dietary Restriction52025
T32HL007901Training in Sleep, Circadian, and Respiratory Neurobiology52025

1 to 10 of 2,275Source NIH's project files

See all 2,275 nih grants

Papers3,143

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Self-assembled micelles of Glycyrrhizic acid and Glabridin: A novel transdermal delivery system with enhanced whitening efficacy.Int J Pharm202642822710PubTator, text miningPubMed
Glucocorticoids Do Not Enhance BK Polyomavirus Replication in Human Renal Proximal Tubular Epithelial Cells In Vitro.Clin Transl Sci202642817405PubTator, text miningPubMed
Trimester-specific associations of methyl-donor nutrients and prenatal dietary patterns with adolescent blood leukocyte circadian gene DNA methylation.J Dev Orig Health Dis202642788273PubTator, text miningPubMed
Diurnal Insulin Clearance and Circadian Metabolic Gene Signatures in MASLD: Integrative Multi-Dataset Physiological and Transcriptomic Analysis.Metabolites202642783754PubTator, text miningPubMed
11β-HSD2 buffers fetal glucocorticoid exposure inducing Per1 expression under maternal stress.PNAS Nexus202642703617PubTator, text miningPubMed
Molecular and clinicopathological insights into oral squamous cell carcinoma: Exploring oxidative stress, ferroptosis, circadian regulation, and novel biomarkers.Cancer Treat Res Commun202642607534PubTator, text miningPubMed
Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes.Diabetology (Basel)202642583078PubTator, text miningPubMed
PER1-related inflammatory signaling links night shift exposure to lower lung function in coal miners.iScience202642541301PubTator, text miningPubMed
Circadian Disruption as a Determinant of the Tumor Temporal State in Colorectal Cancer: A PRISMA-Based Systematic Review Integrating Metabolism, Immunity, and Metastasis.Int J Mol Sci202642511510PubTator, text miningPubMed
Gut Microbiota Modulation as a Therapeutic Strategy for Insomnia: A Systematic Review of Nutritional and Botanical Interventions.Biomolecules202642509727PubTator, text miningPubMed

1 to 10 of 3,143

See all 3,143 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5187

GET https://conductscience.org/api/genes/v1/5187/patents?page=2