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Gene · 5205

ATP8B1: ATPase phospholipid transporting 8B1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ATP8B1: ATPase phospholipid transporting 8B1. Genes, record 5205. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5205

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Gene

Symbol
ATP8B1
HGNC
Name
ATPase phospholipid transporting 8B1
HGNC
NCBI Gene ID
5205
NCBI Gene
HGNC ID
HGNC:3706
HGNC
Ensembl
ENSG00000081923
NCBI Gene
Aliases
ATPIC, BRIC, FIC1, ICP1, PFIC, PFIC1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43520Phospholipid-transporting ATPase IC1,25113Ensembl, GeneID, HGNC

Source UniProt

Patents106

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-2180O43520Espacenet
US 12508234 B22025-12-301O43520Espacenet
JP 2025169942 A2025-11-14855O43520Espacenet
JP 2025169942 A2025-11-14856O43520Espacenet
EP 4640849 A22025-10-294080O43520Espacenet
EP 4641201 A22025-10-2925474O43520Espacenet
JP 2025529142 A2025-09-04536O43520Espacenet
US 12371689 B22025-07-29536O43520Espacenet
US 12365658 B22025-07-221O43520Espacenet
JP 2025521736 A2025-07-101O43520Espacenet

1 to 10 of 106

See all 106 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,495

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleATP8B1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant192025
U01DK062453Colorado Center of Childhood Liver Disease ResearchNetwork162025
P50CA058223SPORE in Breast Cancer142025
R01AI127652Phage resistance and mobile genetic elements in Vibrio cholerae142025
P30CA016056Roswell Park Cancer Center Support Grant132025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease122025
P30CA068485Cancer Center Support Grant102025
P30DK026743UCSF Liver Center102025
P30CA016672Cancer Center Support Grant92025
U01DK062481Advancing our Understanding of Rare Pediatric Liver Diseases92025

1 to 10 of 1,495Source NIH's project files

See all 1,495 nih grants

Papers1,828

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic and clinical spectrum of progressive familial intrahepatic cholestasis type 1: novel ATP8B1 variants and genotype-phenotype correlations.Eur J Pediatr202642760445PubTator, text miningPubMed
Novel genetic variants and atypical phenotypes in pediatric progressive familial intrahepatic cholestasis.Pediatr Res202642754724PubTator, text miningPubMed
Subtype-Dependent Transcriptional Coupling Between DNMT1 and E2F-Linked Proliferative Programs in Breast Cancer: A Dual-Cohort Transcriptomic Analysis.J Cancer202642741635PubTator, text miningPubMed
TFAP2B and FOXC1 are associated with biologically and clinically distinct differentiation states in triple-negative breast cancer.Sci Rep202642728354PubTator, text miningPubMed
A comparative evaluation of quantum machine learning architectures for breast cancer classification using clinical and genomic data.Front Artif Intell202642591753PubTator, text miningPubMed
Use of Next-Generation Sequencing and Whole-Exome Sequencing in the Diagnosis of Adult-Onset Familial Intrahepatic Cholestasis: Challenges in Interpreting Variants of Uncertain Significance.Diagnostics (Basel)202642587573PubTator, text miningPubMed
Tertiary lymphoid structure transcriptomic signatures show limited and cohort-dependent value for predicting axillary nodal involvement in oestrogen receptor-positive luminal breast cancer.Anticancer Drugs202642542556PubTator, text miningPubMed
Multi-omic Profiling of Recurrence Risk Across Breast Cancer Subtypes.medRxiv202642528523PubTator, text miningPubMed
Mechanistic Insights into Autoinhibition of the Human Flippase ATP8B1.J Membr Biol202642517958PubTator, text miningPubMed
Case Report: Recurrent intrahepatic cholestasis: two rare cases with their novel variants of ATB8B1 and atypical clinical findings.Front Med (Lausanne)202642500542PubTator, text miningPubMed

1 to 10 of 1,828

See all 1,828 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5205

GET https://conductscience.org/api/genes/v1/5205/patents?page=2