Gene · 5205
ATP8B1: ATPase phospholipid transporting 8B1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ATP8B1: ATPase phospholipid transporting 8B1. Genes, record 5205. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5205
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43520 | Phospholipid-transporting ATPase IC | 1,251 | 13 | Ensembl, GeneID, HGNC |
Source UniProt
Patents106
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 80 | O43520 | Espacenet |
| US 12508234 B2 | 2025-12-30 | 1 | O43520 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 855 | O43520 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 856 | O43520 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 4080 | O43520 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 25474 | O43520 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 536 | O43520 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 536 | O43520 | Espacenet |
| US 12365658 B2 | 2025-07-22 | 1 | O43520 | Espacenet |
| JP 2025521736 A | 2025-07-10 | 1 | O43520 | Espacenet |
1 to 10 of 106
See all 106 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,495
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ATP8B1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 19 | 2025 |
| U01DK062453 | Colorado Center of Childhood Liver Disease ResearchNetwork | 16 | 2025 |
| P50CA058223 | SPORE in Breast Cancer | 14 | 2025 |
| R01AI127652 | Phage resistance and mobile genetic elements in Vibrio cholerae | 14 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 13 | 2025 |
| P30DK078392 | Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease | 12 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 10 | 2025 |
| P30DK026743 | UCSF Liver Center | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| U01DK062481 | Advancing our Understanding of Rare Pediatric Liver Diseases | 9 | 2025 |
1 to 10 of 1,495Source NIH's project files
See all 1,495 nih grantsPapers1,828
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Genetic and clinical spectrum of progressive familial intrahepatic cholestasis type 1: novel ATP8B1 variants and genotype-phenotype correlations. | Eur J Pediatr | 2026 | 42760445 | PubTator, text mining | PubMed |
| Novel genetic variants and atypical phenotypes in pediatric progressive familial intrahepatic cholestasis. | Pediatr Res | 2026 | 42754724 | PubTator, text mining | PubMed |
| Subtype-Dependent Transcriptional Coupling Between DNMT1 and E2F-Linked Proliferative Programs in Breast Cancer: A Dual-Cohort Transcriptomic Analysis. | J Cancer | 2026 | 42741635 | PubTator, text mining | PubMed |
| TFAP2B and FOXC1 are associated with biologically and clinically distinct differentiation states in triple-negative breast cancer. | Sci Rep | 2026 | 42728354 | PubTator, text mining | PubMed |
| A comparative evaluation of quantum machine learning architectures for breast cancer classification using clinical and genomic data. | Front Artif Intell | 2026 | 42591753 | PubTator, text mining | PubMed |
| Use of Next-Generation Sequencing and Whole-Exome Sequencing in the Diagnosis of Adult-Onset Familial Intrahepatic Cholestasis: Challenges in Interpreting Variants of Uncertain Significance. | Diagnostics (Basel) | 2026 | 42587573 | PubTator, text mining | PubMed |
| Tertiary lymphoid structure transcriptomic signatures show limited and cohort-dependent value for predicting axillary nodal involvement in oestrogen receptor-positive luminal breast cancer. | Anticancer Drugs | 2026 | 42542556 | PubTator, text mining | PubMed |
| Multi-omic Profiling of Recurrence Risk Across Breast Cancer Subtypes. | medRxiv | 2026 | 42528523 | PubTator, text mining | PubMed |
| Mechanistic Insights into Autoinhibition of the Human Flippase ATP8B1. | J Membr Biol | 2026 | 42517958 | PubTator, text mining | PubMed |
| Case Report: Recurrent intrahepatic cholestasis: two rare cases with their novel variants of ATB8B1 and atypical clinical findings. | Front Med (Lausanne) | 2026 | 42500542 | PubTator, text mining | PubMed |
1 to 10 of 1,828
See all 1,828 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5205
GET https://conductscience.org/api/genes/v1/5205/patents?page=2