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PFKFB3: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
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Gene · 5209

Papers3,123

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 3,123

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TitleJournalYearPMIDFound bySource
Targeting PFKFB3 Metabolic Gatekeeping of β-Cell Dysfunctional States Enables Durable Glucose Tolerance in Type 2 Diabetes.bioRxiv202642818175PubTator, text miningPubMed
Mapping immune cell metabolic reprogramming from mechanistic hotspots to translational directions: A bibliometric analysis with exploratory clinical evidence.Hum Immunol202642800206PubTator, text miningPubMed
Lysed erythrocyte membranes metabolically prime endothelial cells for angiogenesis.Angiogenesis202642788982PubTator, text miningPubMed
YTHDF3 promotes angiogenesis in endometriosis by enhancing the translation efficiency of PFKFB3.Angiogenesis202642776305PubTator, text miningPubMed
TRIM28 facilitates diffuse large B-cell lymphoma progression by inducing glycolytic reprogramming through the E2F1/PKM2 axis.Naunyn Schmiedebergs Arch Pharmacol202642760375PubTator, text miningPubMed
The cGAS-STING pathway in acute myocardial infarction: Biomarker discovery and mechanistic insights.PLoS One202642758768PubTator, text miningPubMed
Necroptosis-senescence crosstalk in tubulointerstitial fibrosis: the mtDNA-cGAS-STING-PFKFB3 axis as a metabolic bridge.Front Med (Lausanne)202642755616PubTator, text miningPubMed
NSUN2 promotes glycolysis and stemness of retinoblastoma cells by m5C modification of PFKFB3.Tissue Cell202642753463PubTator, text miningPubMed
Lactylation at H3K18 drives pathological angiogenesis via metabolic-epigenetic crosstalk in ischemic retinopathy.Theranostics202642707676PubTator, text miningPubMed
The role of notch signaling in tumor angiogenesis in hematological malignancies.Front Oncol202642676697PubTator, text miningPubMed
Single-Cell and Machine Learning Analyses Identify a PFKFB3-Centered Regulatory Network and Potential Salidroside Interaction in Coronary Heart Disease.Int J Mol Sci202642653415PubTator, text miningPubMed
Integrated Multi-Omics Analysis and Experimental Validation Identify Acetylation-Related Genes as Potential Regulators in Osteoarthritis.Biomedicines202642652188PubTator, text miningPubMed
Pdcd4-Rictor interaction suppresses mTORC2-PFKFB3 axis and tumorigenesis in NSCLC.Neoplasia202642648032PubTator, text miningPubMed
Efferocytosis regulatory factors in atherosclerosis: A preclinical systematic review.Biochem Biophys Res Commun202642636768PubTator, text miningPubMed
Loss of eIF3m aggravates myocardial ischemia/reperfusion injury via enhancing nitrative damage and inhibiting glycolytic reprogramming.Sci Bull (Beijing)202642632795PubTator, text miningPubMed
Mitochondrial dysfunction in ARDS: unraveling the regulatory networks and therapeutic opportunities.Front Immunol202642592019PubTator, text miningPubMed
Alkyl-chain-length-associated responses of K562 leukemia cells to methyl-, ethyl-, and butylparaben with a focus on PPARγ and WNT/β-catenin signaling.Toxicol Appl Pharmacol202642586446PubTator, text miningPubMed
Mitochondrial bioenergetic remodeling underlies fingolimod-induced immunometabolic adaptation in multiple sclerosis.Biomed Pharmacother202642570637PubTator, text miningPubMed
Tumor-derived extracellular vesicles-mediated oxidative stress transfer activates glycometabolic reprogramming of CAFs.Cell Signal202642567334PubTator, text miningPubMed
The evolving landscape of the Warburg effect in gastric cancer: From molecular mechanisms to targeted therapy.Clin Transl Med202642557756PubTator, text miningPubMed

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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