Gene · 5209
PFKFB3: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PFKFB3: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. Genes, record 5209. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5209
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16875 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 520 | 26 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 35838 | Q16875 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 10214 | Q16875 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 10214 | Q16875 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 527 | Q16875 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 527 | Q16875 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 103498 | Q16875 | Espacenet |
| JP 2020524268 A | 2020-08-13 | 35 | Q16875 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 216273 | Q16875 | Espacenet |
| WO 2018232288 A1 | 2018-12-20 | 22 | Q16875 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 216273 | Q16875 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,912
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PFKFB3 papers | Newest fiscal year |
|---|---|---|---|
| R01HL117913 | The NOTCH Signaling Pathway in Large Vessel Vasculitis | 21 | 2025 |
| U19AI057266 | Vaccine and Infection Induced Immunity in the Young and Aged | 18 | 2025 |
| R01HL142068 | T Cell Immunity in Giant Cell Arteritis | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 7 | 2025 |
| P01CA120964 | Molecular Pathogenesis of the Hamartoma Syndromes | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 5 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| P50CA136393 | Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer | 5 | 2025 |
1 to 10 of 1,912Source NIH's project files
See all 1,912 nih grantsPapers3,123
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Targeting PFKFB3 Metabolic Gatekeeping of β-Cell Dysfunctional States Enables Durable Glucose Tolerance in Type 2 Diabetes. | bioRxiv | 2026 | 42818175 | PubTator, text mining | PubMed |
| Mapping immune cell metabolic reprogramming from mechanistic hotspots to translational directions: A bibliometric analysis with exploratory clinical evidence. | Hum Immunol | 2026 | 42800206 | PubTator, text mining | PubMed |
| Lysed erythrocyte membranes metabolically prime endothelial cells for angiogenesis. | Angiogenesis | 2026 | 42788982 | PubTator, text mining | PubMed |
| YTHDF3 promotes angiogenesis in endometriosis by enhancing the translation efficiency of PFKFB3. | Angiogenesis | 2026 | 42776305 | PubTator, text mining | PubMed |
| TRIM28 facilitates diffuse large B-cell lymphoma progression by inducing glycolytic reprogramming through the E2F1/PKM2 axis. | Naunyn Schmiedebergs Arch Pharmacol | 2026 | 42760375 | PubTator, text mining | PubMed |
| The cGAS-STING pathway in acute myocardial infarction: Biomarker discovery and mechanistic insights. | PLoS One | 2026 | 42758768 | PubTator, text mining | PubMed |
| Necroptosis-senescence crosstalk in tubulointerstitial fibrosis: the mtDNA-cGAS-STING-PFKFB3 axis as a metabolic bridge. | Front Med (Lausanne) | 2026 | 42755616 | PubTator, text mining | PubMed |
| NSUN2 promotes glycolysis and stemness of retinoblastoma cells by m5C modification of PFKFB3. | Tissue Cell | 2026 | 42753463 | PubTator, text mining | PubMed |
| Lactylation at H3K18 drives pathological angiogenesis via metabolic-epigenetic crosstalk in ischemic retinopathy. | Theranostics | 2026 | 42707676 | PubTator, text mining | PubMed |
| The role of notch signaling in tumor angiogenesis in hematological malignancies. | Front Oncol | 2026 | 42676697 | PubTator, text mining | PubMed |
1 to 10 of 3,123
See all 3,123 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5209
GET https://conductscience.org/api/genes/v1/5209/patents?page=2