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Gene · 5209

PFKFB3: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PFKFB3: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. Genes, record 5209. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5209

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Gene

Symbol
PFKFB3
HGNC
Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
HGNC
NCBI Gene ID
5209
NCBI Gene
HGNC ID
HGNC:8874
HGNC
Ensembl
ENSG00000170525
NCBI Gene
Aliases
IPFK2, PFK2, iPFK-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q168756-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 352026Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435838Q16875Espacenet
EP 4650780 A22025-11-1910214Q16875Espacenet
JP 2025517970 A2025-06-1210214Q16875Espacenet
JP 2025062604 A2025-04-14527Q16875Espacenet
US 11446398 B22022-09-20527Q16875Espacenet
JP 2022524081 A2022-04-27103498Q16875Espacenet
JP 2020524268 A2020-08-1335Q16875Espacenet
JP 2019054813 A2019-04-11216273Q16875Espacenet
WO 2018232288 A12018-12-2022Q16875Espacenet
JP 2017121241 A2017-07-13216273Q16875Espacenet

1 to 10 of 27

See all 27 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,912

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePFKFB3 papersNewest fiscal year
R01HL117913The NOTCH Signaling Pathway in Large Vessel Vasculitis212025
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged182025
R01HL142068T Cell Immunity in Giant Cell Arteritis92025
P30CA016672Cancer Center Support Grant82025
UL1TR001863Yale Clinical and Translational Science Award72025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes62025
P30CA008748Cancer Center Support Grant62025
P30CA016087Cancer Center Support Grant52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer52025

1 to 10 of 1,912Source NIH's project files

See all 1,912 nih grants

Papers3,123

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting PFKFB3 Metabolic Gatekeeping of β-Cell Dysfunctional States Enables Durable Glucose Tolerance in Type 2 Diabetes.bioRxiv202642818175PubTator, text miningPubMed
Mapping immune cell metabolic reprogramming from mechanistic hotspots to translational directions: A bibliometric analysis with exploratory clinical evidence.Hum Immunol202642800206PubTator, text miningPubMed
Lysed erythrocyte membranes metabolically prime endothelial cells for angiogenesis.Angiogenesis202642788982PubTator, text miningPubMed
YTHDF3 promotes angiogenesis in endometriosis by enhancing the translation efficiency of PFKFB3.Angiogenesis202642776305PubTator, text miningPubMed
TRIM28 facilitates diffuse large B-cell lymphoma progression by inducing glycolytic reprogramming through the E2F1/PKM2 axis.Naunyn Schmiedebergs Arch Pharmacol202642760375PubTator, text miningPubMed
The cGAS-STING pathway in acute myocardial infarction: Biomarker discovery and mechanistic insights.PLoS One202642758768PubTator, text miningPubMed
Necroptosis-senescence crosstalk in tubulointerstitial fibrosis: the mtDNA-cGAS-STING-PFKFB3 axis as a metabolic bridge.Front Med (Lausanne)202642755616PubTator, text miningPubMed
NSUN2 promotes glycolysis and stemness of retinoblastoma cells by m5C modification of PFKFB3.Tissue Cell202642753463PubTator, text miningPubMed
Lactylation at H3K18 drives pathological angiogenesis via metabolic-epigenetic crosstalk in ischemic retinopathy.Theranostics202642707676PubTator, text miningPubMed
The role of notch signaling in tumor angiogenesis in hematological malignancies.Front Oncol202642676697PubTator, text miningPubMed

1 to 10 of 3,123

See all 3,123 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5209

GET https://conductscience.org/api/genes/v1/5209/patents?page=2