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PFKFB3: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
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Gene · 5209

Papers3,123

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

121 to 140 of 3,123

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TitleJournalYearPMIDFound bySource
ETS Variant Transcription Factor 6 Promotes Glucose Metabolism Reprogramming in HCC.J Cell Mol Med202641631407PubTator, text miningPubMed
Sepsis and the immunometabolic inflammatory response.NPJ Metab Health Dis202641629610PubTator, text miningPubMed
The moonlighting functions of glycolytic enzymes in tumorigenesis.Cell Oncol (Dordr)202641627634PubTator, text miningPubMed
Loss of Cathepsin K Impairs Collagen Biogenesis and Enhances Actin Polymerization in Trabecular Meshwork.Invest Ophthalmol Vis Sci202641615370PubTator, text miningPubMed
Glucose Metabolic Enzyme PFKFB3 in Cardiopulmonary Vascular Health and Disease.Circ Res202641610189PubTator, text miningPubMed
PFKFB3 exacerbates myocardial injury by accelerating CXCR4hi neutrophil mobilization after acute myocardial infarction.PLoS One202641610117PubTator, text miningPubMed
Lactate-lactylation in tumor angiogenesis and progression: mechanisms, biomarker potential, and therapeutic implications.Biomark Res202641593811PubTator, text miningPubMed
Protein kinase D: Integrating cancer and metabolic disorders.Mol Aspects Med202641587506PubTator, text miningPubMed
Role of elevation of glycolysis in tumor-associated macrophages in glioblastoma immune evasion and therapeutic implications.PNAS Nexus202641567927PubTator, text miningPubMed
Emerging frontiers in the mitochondrial regulation of dendritic cell biology.Redox Biol202641564795PubTator, text miningPubMed
The role of metformin in extracellular matrix-based three-dimensional cell culture Models: A mini-review on therapeutic potentials.Biochem Biophys Rep202641561225PubTator, text miningPubMed
Exosomal microRNA-448 suppresses the malignant behaviors of liver cancer cells by targeting RAB7A and inhibiting glycolysis.Oncol Lett202641551341PubTator, text miningPubMed
Daucosterol Targets PFKFB3 to Mitigates Sepsis-Induced Acute Lung Injury by Inhibiting Glycolysis and M1 Macrophage Polarization.Chem Biol Drug Des202641549474PubTator, text miningPubMed
Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation.Inflammation202641543766PubTator, text miningPubMed
NAT10 promotes the glycolysis of retinoblastoma through ac4C modification of PFKFB3 mRNA.BMC Cancer202641540352PubTator, text miningPubMed
F2,6BP restores mitochondrial genome integrity in Huntington's disease.J Biol Chem202641534834PubTator, text miningPubMed
PFKFB3-involved glycolytic metabolism supports sepsis-induced neutrophil extracellular trap formation.Int Immunopharmacol202641512792PubTator, text miningPubMed
Metabolic alterations driven by PFKFB3 upregulation confer resistance to trastuzumab in HER2-positive breast cancer.Biomed Pharmacother202641496324PubTator, text miningPubMed
Unveiling the active component of HuoXueTongFu formula: Emodin attenuates postoperative intra-abdominal adhesion by inhibiting HIF-1α-mediated glycolytic reprogramming.Phytomedicine202641447843PubTator, text miningPubMed
Immune cell-derived cytokines synergistically interact to drive synovial fibroblast invasive function and metabolic capacity.J Autoimmun202641435749PubTator, text miningPubMed

gene-search-2026-11-11-0.2.0

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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