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Gene · 5216

PFN1: profilin 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PFN1: profilin 1. Genes, record 5216. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5216

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Gene

Symbol
PFN1
HGNC
Name
profilin 1
HGNC
NCBI Gene ID
5216
NCBI Gene
HGNC ID
HGNC:8881
HGNC
Ensembl
ENSG00000108518
NCBI Gene
Aliases
ALS18, PDB7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07737Profilin-114022Ensembl, GeneID, HGNC

Source UniProt

Patents71

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4694917 A12026-02-18631P07737Espacenet
EP 4650780 A22025-11-19635P07737Espacenet
JP 2025147176 A2025-10-0610269P07737Espacenet
JP 2025529142 A2025-09-047327P07737Espacenet
US 12371689 B22025-07-297327P07737Espacenet
JP 2025517970 A2025-06-12635P07737Espacenet
JP 2025028160 A2025-02-2810269P07737Espacenet
KR 1020250010750 A2025-01-2110269P07737Espacenet
US 12097221 B22024-09-2420P07737Espacenet
JP 2024123008 A2024-09-107805P07737Espacenet

1 to 10 of 71

See all 71 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,607

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePFN1 papersNewest fiscal year
T32HL076124Cardiovascular Bioengineering Training Program102025
R01CA248873Profilin biology in breast cancer92025
T32HL129964Training Program in Imaging Sciences in Translational Cardiovascular Research72025
P30CA091842Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant52025
R01CA271095Transcriptional Regulation of Dormancy and Emergence in Breast Cancer52025
R01GM073791Structural-Functional Basis of Actin Cytoskeleton Dynamics52025
R01GM114666Molecular Mechanisms of Bacterial Toxins Targeting the Actin Cytoskeleton52025
R35GM133485Mechanisms of coordinated actin and microtubule dynamics52025
P30CA021765Cancer Center Support Grant (CCSG)42025

1 to 10 of 1,607Source NIH's project files

See all 1,607 nih grants

Papers2,319

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A novel tRNA-derived fragment, tRF-16-WSNKP9D promotes malignant progression of colorectal carcinoma through mediating PFN1.Genomics202642805318PubTator, text miningPubMed
In Vitro Analysis of Profilin 1 Binding to Recombinant Actin.Methods Mol Biol202642681009PubTator, text miningPubMed
DIA-based serum proteomics of the complement-coagulation cascade identifies candidate biomarkers for myasthenia gravis.Front Neurosci202642516550PubTator, text miningPubMed
SLC3A2-mediated BCAAs transport promotes airway inflammation and remodeling in chronic obstructive pulmonary disease via acetylation of PFN1.J Adv Res202642448278PubTator, text miningPubMed
ASAP-ID: Proximity Labelling With Small Tags.Mol Cell Proteomics202642362190PubTator, text miningPubMed
Proteomic profile of bone in patients with acromegaly: new insights from a pilot exploratory study.J Endocrinol Invest202642329359PubTator, text miningPubMed
Profilin-1 as a Potential Biomarker in Acute Ischemic Stroke: Predictive Value for Large Vessel Occlusion and Mechanical Thrombectomy.Clin Lab202642295319PubTator, text miningPubMed
PFN1 inhibits lytic replication of Kaposi sarcoma-associated herpesvirus through SQSTM1/p62-mediated selective autophagy targeting the KSHV helicase.Autophagy202642260986Swiss-Prot, curatedPubMed
From bone alterations to tumours: Genetic drivers linking Paget's disease of bone to cancer.Crit Rev Oncol Hematol202642208632PubTator, text miningPubMed
A pilot shotgun proteomic profiling of peripheral blood mononuclear cells in patients with different MRI phenotypes of cerebral small vessel disease.Biomed Khim202642183763PubTator, text miningPubMed

1 to 10 of 2,319

See all 2,319 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5216

GET https://conductscience.org/api/genes/v1/5216/patents?page=2