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Gene · 5223

PGAM1: phosphoglycerate mutase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PGAM1: phosphoglycerate mutase 1. Genes, record 5223. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5223

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Gene

Symbol
PGAM1
HGNC
Name
phosphoglycerate mutase 1
HGNC
NCBI Gene ID
5223
NCBI Gene
HGNC ID
HGNC:8888
HGNC
Ensembl
ENSG00000171314
NCBI Gene
Aliases
HEL-S-35, PGAM-B, PGAMA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P18669Phosphoglycerate mutase 125433Ensembl, GeneID, HGNC

Source UniProt

Patents79

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026022479 A12026-01-291P18669Espacenet
JP 2026004568 A2026-01-1457850P18669Espacenet
EP 4650780 A22025-11-1939423P18669Espacenet
EP 4650780 A22025-11-198870P18669Espacenet
EP 4640238 A12025-10-291P18669Espacenet
EP 4641201 A22025-10-299095P18669Espacenet
US 12441764 B22025-10-142P18669Espacenet
JP 2025517969 A2025-06-129095P18669Espacenet
JP 2025517970 A2025-06-128870P18669Espacenet
JP 2025517970 A2025-06-1239423P18669Espacenet

1 to 10 of 79

See all 79 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants918

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePGAM1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
P30CA008748Cancer Center Support Grant62025
R01CA140515Signaling importance of ‘functionless’ lyso-PAF, an inactive form of platelet activating factor, in melanoma with mutant Nras52025
P30CA014195Cancer Center Support Grant (CCSG)42025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes32025
P30CA006973Regional Oncology Research Center32025
P30CA016042Cancer Center Support Grant32025
P30CA016087Cancer Center Support Grant32025
P30CA138292Winship Cancer Institute Cancer Center Support Grant32025
R35CA220449Human metabolic variation as a window into cancer initiation and progression32025

1 to 10 of 918Source NIH's project files

See all 918 nih grants

Papers1,506

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The impact of low carbohydrate diet on the plasma proteomic profile of individuals with obesity.Front Nutr202642780918PubTator, text miningPubMed
KDM6B inhibition modulates monocyte activation and alleviates IMQ-induced psoriasis-like skin inflammation.Cell Commun Signal202642732058PubTator, text miningPubMed
Targeting PGAM1 Y119 phosphorylation resensitizes non-small-cell lung cancer to cisplatin therapy by promoting oxidative stress and DNA damage.J Biol Chem202642680101PubTator, text miningPubMed
The function of phosphoglycerate mutase 1 (PGAM1) and its role in diseases.Front Mol Biosci202642676892PubTator, text miningPubMed
PGAM1 rheostat in glycolysis and autophagy.Nat Cell Biol202642567989PubTator, text miningPubMed
The glycolytic enzyme PGAM1 functions as a metabolic-autophagy checkpoint to coordinate growth and stress tolerance.Nat Cell Biol202642527668PubTator, text miningPubMed
N4-acetylcytidine modification bridges metabolic reprogramming and immune evasion in cancer: mechanisms and therapeutic implications.Front Immunol202642445196PubTator, text miningPubMed
USP20-mediated PGAM1 stabilization promotes glycolysis and confers osimertinib resistance in non-small cell lung carcinoma.Oncogene202642420587PubTator, text miningPubMed
Correction: LncRNA SPINT1-AS1 enhances the Warburg effect and promotes the progression of osteosarcoma via the miR-135b-5p/PGAM1 axis.Cancer Cell Int202642316270PubTator, text miningPubMed
The Warburg effect provides attributes that facilitate tumor-cell resistance.Histol Histopathol202642311140PubTator, text miningPubMed

1 to 10 of 1,506

See all 1,506 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5223

GET https://conductscience.org/api/genes/v1/5223/patents?page=2