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Gene · 5225

PGC: progastricsin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PGC: progastricsin. Genes, record 5225. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5225

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Gene

Symbol
PGC
HGNC
Name
progastricsin
HGNC
NCBI Gene ID
5225
NCBI Gene
HGNC ID
HGNC:8890
HGNC
Ensembl
ENSG00000096088
NCBI Gene
Aliases
PEPC, PGII
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20142Gastricsin3882Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459095P20142Espacenet
EP 4650780 A22025-11-199220P20142Espacenet
JP 2025147176 A2025-10-0610296P20142Espacenet
JP 2025529142 A2025-09-047333P20142Espacenet
WO 2025162587 A12025-08-0769P20142Espacenet
US 12371689 B22025-07-297333P20142Espacenet
WO 2025125234 A12025-06-1917P20142Espacenet
JP 2025517970 A2025-06-129220P20142Espacenet
JP 2025028160 A2025-02-2810296P20142Espacenet
KR 1020250010750 A2025-01-2110296P20142Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants868

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePGC papersNewest fiscal year
P30DK058404Molecular and Cellular Basis for Digestive Diseases122025
R01HL095993Derivation of lung epithelia from iPS cells for advanced disease modeling92025
P30CA068485Cancer Center Support Grant82025
R01DK094989REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUS82025
P30DK056338Texas Medical Center Digestive Diseases Center62025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease62025
R01DK101332Induction and Evolution of Metaplasia in the Stomach62025
P01CA116087H. pylori-induced Inflammation and Gastric Cancer52025
P30DK052574Host-environment interactions in the pathophysiology of digestive disease52025
R01DK105129MECHANISMS OF CHIEF CELL DEDIFFERENTIATION52025

1 to 10 of 868Source NIH's project files

See all 868 nih grants

Papers2,033

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Serology and magnetically controlled capsule gastroscopy for opportunistic screening of high-risk events in gastric cancer development: a cross-sectional study.Front Med (Lausanne)202642682437PubTator, text miningPubMed
Physical, chemical, and structural properties of human gastric organoid-derived mucus.Am J Physiol Gastrointest Liver Physiol202642460667PubTator, text miningPubMed
Development and internal validation of a risk prediction model for gastric precancerous lesions integrating Helicobacter pylori serologic typing and host susceptibility polymorphisms.Medicine (Baltimore)202642410859PubTator, text miningPubMed
Endoscopic spectrum of autoimmune gastritis across disease stages: a focus on Barrett's esophagus and ME-NBI features.Front Immunol202642317341PubTator, text miningPubMed
[Combined assessment of gastric mucosal damage associated with Helicobacter pylori infection in children by virulence factors and pepsinogen].Zhongguo Dang Dai Er Ke Za Zhi202642305000PubTator, text miningPubMed
Lineage tracing of soma-to-primordial germ cell-like conversion in human tumor cell line.iScience202642291258PubTator, text miningPubMed
Longitudinal Changes in the Serum Pepsinogen I/II Ratio With Progression of Gastric Atrophy.J Clin Lab Anal202642179212PubTator, text miningPubMed
Inflammatory Cytokines as Potential Inducements of Early Gastric Mucosal Lesions in Helicobacter pylori-Infected Patients.Gastroenterol Res Pract202642157998PubTator, text miningPubMed
Progastricsin (Pepsinogen C) is downregulated in gastric adenocarcinoma: evidence from a South Asian population.BMC Cancer202642116048PubTator, text miningPubMed
An Epidemiological Study on the Relationship between Gastric Mucosal Atrophy, Exhaled Hydrogen Concentration, and Gut Microbiota.Digestion202642048281PubTator, text miningPubMed

1 to 10 of 2,033

See all 2,033 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5225

GET https://conductscience.org/api/genes/v1/5225/patents?page=2