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PGF: placental growth factor

1 protein, 112 patents, 3 drugs, 401 trials, 4,060 NIH grants and 12,642 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPGFHGNC
Nameplacental growth factorHGNC
NCBI Gene ID5228NCBI Gene
HGNC IDHGNC:8893HGNC
EnsemblENSG00000119630NCBI Gene
AliasesD12S1900, PGFL, PIGF, PLGF, PlGF, PlGF-2, SHGC-10760NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P49763Placenta growth factor2212Ensembl, GeneID, HGNCUniProt

Patents 112

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1911923P49763Espacenet
JP 2025147176 A2025-10-0610298P49763Espacenet
JP 2025529142 A2025-09-047334P49763Espacenet
US 12371689 B22025-07-297334P49763Espacenet
JP 2025517970 A2025-06-1211923P49763Espacenet
JP 2025065465 A2025-04-178P49763Espacenet
JP 2025028160 A2025-02-2810298P49763Espacenet
KR 1020250010750 A2025-01-2110298P49763Espacenet
EP 4491229 A22025-01-15177P49763Espacenet
WO 2024252368 A22024-12-12218P49763Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AFLIBERCEPTCHEMBL1742982Placenta growth factor inhibitorINHIBITORChEMBL
CONBERCEPTCHEMBL2108313Placenta growth factor inhibitorINHIBITORChEMBL
TB-403CHEMBL2109545Placenta growth factor inhibitorINHIBITORChEMBL

Trials 401

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07557121AFLIBERCEPTPHASE2ClinicalTrials.gov
NCT07520318AFLIBERCEPTPHASE2/PHASE3ClinicalTrials.gov
NCT07496567AFLIBERCEPTPHASE2/PHASE3ClinicalTrials.gov
NCT07489131AFLIBERCEPTPHASE3ClinicalTrials.gov
NCT07482176AFLIBERCEPTPHASE3ClinicalTrials.gov
NCT07449936AFLIBERCEPTPHASE3ClinicalTrials.gov
NCT07440225AFLIBERCEPTPHASE2/PHASE3ClinicalTrials.gov
NCT07434713AFLIBERCEPTClinicalTrials.gov
NCT07423429AFLIBERCEPTClinicalTrials.gov
NCT07390253AFLIBERCEPTClinicalTrials.gov

NIH grants 4060

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition602,025NIH's project files
P30CA016672Cancer Center Support Grant412,025NIH's project files
T32HL105324Hypertension and Cardiorenal Research Training Program222,025NIH's project files
P30CA008748Cancer Center Support Grant192,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award162,025NIH's project files
P20GM121334Mississippi Center of Excellence in Perinatal Research, Phase 2142,025NIH's project files
P30CA006973Regional Oncology Research Center132,025NIH's project files
UG1HD027915NICHD maternal fetal medicine units network92,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant82,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant82,025NIH's project files

Papers 12642

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827416PubTator, text miningPubMed
42801806PubTator, text miningPubMed
42800417PubTator, text miningPubMed
42796224PubTator, text miningPubMed
42793748PubTator, text miningPubMed
42791229PubTator, text miningPubMed
42787653PubTator, text miningPubMed
42787613PubTator, text miningPubMed
42787257PubTator, text miningPubMed
42786879PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license