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Gene · 5244

ABCB4: ATP binding cassette subfamily B member 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ABCB4: ATP binding cassette subfamily B member 4. Genes, record 5244. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5244

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Gene

Symbol
ABCB4
HGNC
Name
ATP binding cassette subfamily B member 4
HGNC
NCBI Gene ID
5244
NCBI Gene
HGNC ID
HGNC:45
HGNC
Ensembl
ENSG00000005471
NCBI Gene
Aliases
ABC21, GBD1, ICP3, MDR2, MDR2/3, MDR3, PFIC-3, PGY3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P21439Phosphatidylcholine translocator ABCB41,2864Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-2182P21439Espacenet
JP 2025169942 A2025-11-14866P21439Espacenet
EP 4641201 A22025-10-292104P21439Espacenet
JP 2025529142 A2025-09-04190P21439Espacenet
US 12371689 B22025-07-29190P21439Espacenet
JP 2025517969 A2025-06-122104P21439Espacenet
JP 2025062604 A2025-04-147643P21439Espacenet
JP 2023521663 A2023-05-2581P21439Espacenet
US 11446398 B22022-09-207643P21439Espacenet
US 11400116 B22022-08-024494P21439Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,715

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleABCB4 papersNewest fiscal year
P30DK034989Yale Liver Center242025
IK6BX004601BLR&D Research Career Scientist Award222025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease172025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology102025
U01DK062453Colorado Center of Childhood Liver Disease ResearchNetwork82025
P30DK026743UCSF Liver Center72025
P30DK034854Integrated Epithelial and Muscosal Biology72025
R01DK057993Pathophysiology of Biliary Disease72025
U01DK062497Clinical Center for Cholestatic Liver Disease in Children72025
UL1TR001863Yale Clinical and Translational Science Award72025

1 to 10 of 1,715Source NIH's project files

See all 1,715 nih grants

Papers3,400

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Metformin Drives Hepatocyte Molecular Reprogramming Through a Fibroblast Growth Factor 1-Fibroblast Growth Factor Receptor 4-T-Box Transcription Factor 3 Axis in Cholestasis.Cell Mol Gastroenterol Hepatol202642822673PubTator, text miningPubMed
Heterozygous CFTR variants associated with low-phospholipid-associated cholelithiasis phenotypes expand hepatobiliary disorders spectrum.J Cyst Fibros202642791119PubTator, text miningPubMed
Early predictors of pruritus response in children with PFIC treated with odevixibat.Dig Liver Dis202642773017PubTator, text miningPubMed
Novel genetic variants and atypical phenotypes in pediatric progressive familial intrahepatic cholestasis.Pediatr Res202642754724PubTator, text miningPubMed
Identification of a new, likely pathogenic, heterozygous ABCB4 variant causing low phospholipid-associated cholelithiasis.BMJ Case Rep202642728079PubTator, text miningPubMed
Blood Bile Acids for Inflammatory Bowel Disease Diagnosis and Disease Activity Assessment: A Metabolomics Meta-Analysis.J Proteome Res202642695907PubTator, text miningPubMed
Use of Next-Generation Sequencing and Whole-Exome Sequencing in the Diagnosis of Adult-Onset Familial Intrahepatic Cholestasis: Challenges in Interpreting Variants of Uncertain Significance.Diagnostics (Basel)202642587573PubTator, text miningPubMed
Trends and Characteristics of Drug-Resistant Tuberculosis: A Five-Year Study at a Major Specialized Hospital in Guizhou, China (2018-2023).Infect Drug Resist202642572727PubTator, text miningPubMed
Adenosine triphosphate-binding cassette transporters: key players in maintaining fetal health during pregnancy.Front Endocrinol (Lausanne)202642534682PubTator, text miningPubMed
Correction to "POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation".Adv Sci (Weinh)202642532019PubTator, text miningPubMed

1 to 10 of 3,400

See all 3,400 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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