Gene · 5245
PHB1: prohibitin 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PHB1: prohibitin 1. Genes, record 5245. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5245
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P35232 | Prohibitin 1 | 272 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents100
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12605438 B2 | 2026-04-21 | 6 | P35232 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 59144 | P35232 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4003 | P35232 | Espacenet |
| EP 4641203 A2 | 2025-10-29 | 129 | P35232 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 10322 | P35232 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 10323 | P35232 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 10324 | P35232 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15482 | P35232 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7340 | P35232 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7340 | P35232 | Espacenet |
1 to 10 of 100
See all 100 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,649
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PHB1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 9 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| R01HD007857 | Sex Hormone Receptor Component And The Cell Genome | 6 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 5 | 2025 |
| P30CA036727 | Buffett Cancer Center Support Grant | 4 | 2025 |
| R01CA172310 | Novel Targeted Anticancer Agents from Marine Cyanobacteria | 4 | 2025 |
| U54CA118638 | 1/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership | 4 | 2025 |
| ZIACP010121 | Molecular Epidemiology Studies of Occupational and Environmental Exposures | 4 | 2025 |
| P30CA022453 | CANCER CENTER SUPPORT GRANT | 3 | 2025 |
1 to 10 of 1,649Source NIH's project files
See all 1,649 nih grantsPapers3,130
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| [The mitochondrial protein encoded by circUSP25 promotes colon cancer cell proliferation and migration]. | Nan Fang Yi Ke Da Xue Xue Bao | 2026 | 42812058 | PubTator, text mining | PubMed |
| Prohibitin 2 mediates the mitochondrial protective effect of the whey-derived tetrapeptide Gly-Thr-Trp-Tyr. | Biochem Biophys Res Commun | 2026 | 42785177 | PubTator, text mining | PubMed |
| A Transport-Driven Conceptual Framework for the Biodegradation of FFF-Printed PLA/PHB Structures: Integrating Evidence from Complementary Experimental Studies. | J Funct Biomater | 2026 | 42783683 | PubTator, text mining | PubMed |
| Extracellular vesicle-based therapies in IBD: immunomodulation, regeneration, and translation. | Front Immunol | 2026 | 42769978 | PubTator, text mining | PubMed |
| Prohibitin controls MRS2-Mediated mitochondrial Mg2+ uptake to Shape bioenergetics. | Cell Rep | 2026 | 42658678 | PubTator, text mining | PubMed |
| Motif-Cluster: Motif driven prioritization of transcription factor binding clusters. | PLoS Comput Biol | 2026 | 42555666 | PubTator, text mining | PubMed |
| Downregulation of PHB1 due to Loss of VHL Protein Expression Promotes the Malignancy Progression of Kidney Renal Clear Cell Carcinoma. | Front Biosci (Landmark Ed) | 2026 | 42530252 | PubTator, text mining | PubMed |
| [Molecular mechanisms of the geroprotective effect of exosomes in the simulation of inflammaging in the culture of human fibroblasts.] | Adv Gerontol | 2026 | 42502941 | PubTator, text mining | PubMed |
| Protein Profile of Multiple Myeloma-Derived Extracellular Vesicles for the Discovery of Novel Myeloma-Related Biomarkers. | Cancer Sci | 2026 | 42460505 | PubTator, text mining | PubMed |
| Addendum: In situ architecture of the human prohibitin complex. | Nat Cell Biol | 2026 | 42410115 | PubTator, text mining | PubMed |
1 to 10 of 3,130
See all 3,130 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5245
GET https://conductscience.org/api/genes/v1/5245/patents?page=2