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Gene · 5245

PHB1: prohibitin 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PHB1: prohibitin 1. Genes, record 5245. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5245

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Gene

Symbol
PHB1
HGNC
Name
prohibitin 1
HGNC
NCBI Gene ID
5245
NCBI Gene
HGNC ID
HGNC:8912
HGNC
Ensembl
ENSG00000167085
NCBI Gene
Aliases
BAP32, HEL-215, HEL-S-54e, PHB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35232Prohibitin 12726Ensembl, GeneID, HGNC

Source UniProt

Patents100

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12605438 B22026-04-216P35232Espacenet
JP 2026004568 A2026-01-1459144P35232Espacenet
EP 4650780 A22025-11-194003P35232Espacenet
EP 4641203 A22025-10-29129P35232Espacenet
JP 2025147176 A2025-10-0610322P35232Espacenet
JP 2025147176 A2025-10-0610323P35232Espacenet
JP 2025147176 A2025-10-0610324P35232Espacenet
JP 2025147176 A2025-10-0615482P35232Espacenet
JP 2025529142 A2025-09-047340P35232Espacenet
US 12371689 B22025-07-297340P35232Espacenet

1 to 10 of 100

See all 100 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,649

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePHB1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
P40OD010440Caenorhabditis Genetics Center92025
P30CA008748Cancer Center Support Grant82025
R01HD007857Sex Hormone Receptor Component And The Cell Genome62025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control52025
P30CA036727Buffett Cancer Center Support Grant42025
R01CA172310Novel Targeted Anticancer Agents from Marine Cyanobacteria42025
U54CA1186381/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership42025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
P30CA022453CANCER CENTER SUPPORT GRANT32025

1 to 10 of 1,649Source NIH's project files

See all 1,649 nih grants

Papers3,130

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
[The mitochondrial protein encoded by circUSP25 promotes colon cancer cell proliferation and migration].Nan Fang Yi Ke Da Xue Xue Bao202642812058PubTator, text miningPubMed
Prohibitin 2 mediates the mitochondrial protective effect of the whey-derived tetrapeptide Gly-Thr-Trp-Tyr.Biochem Biophys Res Commun202642785177PubTator, text miningPubMed
A Transport-Driven Conceptual Framework for the Biodegradation of FFF-Printed PLA/PHB Structures: Integrating Evidence from Complementary Experimental Studies.J Funct Biomater202642783683PubTator, text miningPubMed
Extracellular vesicle-based therapies in IBD: immunomodulation, regeneration, and translation.Front Immunol202642769978PubTator, text miningPubMed
Prohibitin controls MRS2-Mediated mitochondrial Mg2+ uptake to Shape bioenergetics.Cell Rep202642658678PubTator, text miningPubMed
Motif-Cluster: Motif driven prioritization of transcription factor binding clusters.PLoS Comput Biol202642555666PubTator, text miningPubMed
Downregulation of PHB1 due to Loss of VHL Protein Expression Promotes the Malignancy Progression of Kidney Renal Clear Cell Carcinoma.Front Biosci (Landmark Ed)202642530252PubTator, text miningPubMed
[Molecular mechanisms of the geroprotective effect of exosomes in the simulation of inflammaging in the culture of human fibroblasts.]Adv Gerontol202642502941PubTator, text miningPubMed
Protein Profile of Multiple Myeloma-Derived Extracellular Vesicles for the Discovery of Novel Myeloma-Related Biomarkers.Cancer Sci202642460505PubTator, text miningPubMed
Addendum: In situ architecture of the human prohibitin complex.Nat Cell Biol202642410115PubTator, text miningPubMed

1 to 10 of 3,130

See all 3,130 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5245

GET https://conductscience.org/api/genes/v1/5245/patents?page=2