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Gene · 5251

PHEX: phosphate regulating endopeptidase X-linked

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PHEX: phosphate regulating endopeptidase X-linked. Genes, record 5251. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5251

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Gene

Symbol
PHEX
HGNC
Name
phosphate regulating endopeptidase X-linked
HGNC
NCBI Gene ID
5251
NCBI Gene
HGNC ID
HGNC:8918
HGNC
Ensembl
ENSG00000102174
NCBI Gene
Aliases
HPDR, HPDR1, HYP, HYP1, LXHR, PEX, XLH
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P78562Phosphate-regulating neutral endopeptidase PHEX7490Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457569P78562Espacenet
EP 4641202 A22025-10-29580P78562Espacenet
JP 2025529142 A2025-09-043458P78562Espacenet
US 12371689 B22025-07-293458P78562Espacenet
KR 1020250017231 A2025-02-04580P78562Espacenet
US 11446398 B22022-09-2062489P78562Espacenet
US 11400116 B22022-08-02130P78562Espacenet
JP 2022524081 A2022-04-27165460P78562Espacenet
US 11078247 B22021-08-038403P78562Espacenet
US 10918740 B22021-02-167449P78562Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants767

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePHEX papersNewest fiscal year
UL1TR001863Yale Clinical and Translational Science Award92025
ZIADE000649Skeletal Disorders and Mineral Homeostasis Section82025
P30AR072581Indiana Core Center for Clinical Research in Musculoskeletal Health62025
P30CA054174Mays Cancer Center at UT Health SA32025
P30CA008748Cancer Center Support Grant22025
P30CA034196Cancer Center Support (CORE) Grant22025
P30DK045735Yale Diabetes Research Center22025
R01DK112955Repurposing rifampin to reduce elevated levels of blood and urine calcium in patients with inactivating mutations of CYP24A122025
T32MH018268Training Program in Childhood Neuropsychiatric Disorders22025
T32MH019836Postdoctoral Training Program in Stress and Trauma22025

1 to 10 of 767Source NIH's project files

See all 767 nih grants

Papers1,921

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
X-linked hypophosphatemic rickets: case report with perspectives and challenges.Einstein (Sao Paulo)202642820547PubTator, text miningPubMed
Expression of concern for "The critical interaction of the metallopeptidase PHEX with heparan sulfate proteoglycans" [Int. J. Biochem. Cell Biol. 40 (2008) 2781-2792].Int J Biochem Cell Biol202642805845PubTator, text miningPubMed
Exploring the Association of Angiotensin-(1-7) with Left Ventricular Mass Index in Youth with Hereditary Hypophosphatemia: A Pilot Study.Res Sq202642779992PubTator, text miningPubMed
Noncanonical Splice Site Disruption: +4 Intronic Variant in Phosphate-Regulating Endopeptidase Homolog, X-linked (PHEX Gene) Supported by In Silico Analysis in X-linked Hypophosphatemic Rickets.Cureus202642763725PubTator, text miningPubMed
Occult Maxillary Sinus Phosphaturic Mesenchymal Tumor Localized by 68 Ga-DOTATATE PET/CT After Repeated Negative Parathyroid Imaging.Clin Nucl Med202642725475PubTator, text miningPubMed
Uncovering sodium overload-associated gene signatures in chronic obstructive pulmonary disease through integrated bioinformatics and machine learning.J Thorac Dis202642724664PubTator, text miningPubMed
Synergistic Combination of Hypericin-Mediated Photodynamic Therapy and HIF-1α siRNA Inhibits Triple-Negative Breast Cancer via Inducing PANoptosis in vitro.Cancer Manag Res202642688896PubTator, text miningPubMed
Two variants in SLC34A3 in a patient with X-linked hypophosphatemia: a diagnostic and therapeutic dilemma.Pediatr Nephrol202642684400PubTator, text miningPubMed
Dental phenotypes associated with novel PHEX variants in X-linked hypophosphatemia.Arch Oral Biol202642612326PubTator, text miningPubMed
Effects of burosumab on macrophage polarization and TRPV1 expression in children with XLH.Endocr Connect202642560767PubTator, text miningPubMed

1 to 10 of 1,921

See all 1,921 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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