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Gene · 5268

SERPINB5: serpin family B member 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SERPINB5: serpin family B member 5. Genes, record 5268. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5268

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Gene

Symbol
SERPINB5
HGNC
Name
serpin family B member 5
HGNC
NCBI Gene ID
5268
NCBI Gene
HGNC ID
HGNC:8949
HGNC
Ensembl
ENSG00000206075
NCBI Gene
Aliases
PI5, maspin
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P36952Serpin B53754Ensembl, GeneID, HGNC

Source UniProt

Patents97

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11207P36952Espacenet
JP 2026004568 A2026-01-1463196P36952Espacenet
JP 2025013347 A2025-01-24207P36952Espacenet
EP 4487869 A22025-01-08440P36952Espacenet
EP 4406585 A22024-07-31207P36952Espacenet
KR 1020240027895 A2024-03-04696P36952Espacenet
JP 2023036863 A2023-03-14696P36952Espacenet
JP 2023011696 A2023-01-24207P36952Espacenet
JP 2023011697 A2023-01-24207P36952Espacenet
US 11446398 B22022-09-2078093P36952Espacenet

1 to 10 of 97

See all 97 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,207

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSERPINB5 papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
P30CA022453CANCER CENTER SUPPORT GRANT92025
P30ES006694Southwest Environmental Health Sciences Center72025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant62025
P30CA006973Regional Oncology Research Center52025
P30CA008748Cancer Center Support Grant42025
P30CA016086Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
P30CA076292Moffitt Cancer Center Support Grant42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025

1 to 10 of 1,207Source NIH's project files

See all 1,207 nih grants

Papers2,479

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Trichostatin A ameliorates ulcerative colitis via the SERPINB5-mediated MMP9/RLN2 signaling pathway.Pathol Res Pract202642735487PubTator, text miningPubMed
Identification and validation of an alternatively spliced novel isoform of maspin that modulate genes involved in inflammatory and apoptotic pathways.Gene202642731685PubTator, text miningPubMed
PPM1B suppresses cervical carcinoma invasion by dephosphorylating MYPT1 at Thr853 and inactivating the PRMT5 epigenetic axis.Eur J Cell Biol202642585950PubTator, text miningPubMed
Diagnostic utility of p57Kip2, p53, and maspin in classifying hydatidiform moles.Sci Rep202642457916PubTator, text miningPubMed
CRISPR/Cas9-mediated miR-21 editing in high-grade urothelial carcinoma cells and its biological effects.Mol Biol Rep202642319574PubTator, text miningPubMed
Maspin Modulates Malignant Phenotypes Depending on Subcellular Localization in Pancreatic Ductal Adenocarcinoma Cell Lines.Cancers (Basel)202642279399PubTator, text miningPubMed
Emphysema Shapes a Pro-Inflammatory Immune Microenvironment in Pulmonary Adenocarcinoma: A Pilot Immune Transcriptomic Profiling Study.Int J Mol Sci202642123542PubTator, text miningPubMed
Myoepithelial cell cartography: A review of immunohistochemical markers in salivary gland neoplasms.Histol Histopathol202642052808PubTator, text miningPubMed
Correction: METTL3/YTHDF1 drives M1 macrophage polarization and aggravates ulcerative colitis progression by regulating m6A modification of SerpinB5 mRNA and FBXO32-dependent NF-κB pathway.J Gastroenterol202641961123PubTator, text miningPubMed
Molecular mechanisms and therapeutic strategies: DNA methylation in pancreatic cancer.Cancer Biol Ther202641879036PubTator, text miningPubMed

1 to 10 of 2,479

See all 2,479 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5268

GET https://conductscience.org/api/genes/v1/5268/patents?page=2