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Gene · 5270

SERPINE2: serpin family E member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SERPINE2: serpin family E member 2. Genes, record 5270. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5270

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Gene

Symbol
SERPINE2
HGNC
Name
serpin family E member 2
HGNC
NCBI Gene ID
5270
NCBI Gene
HGNC ID
HGNC:8951
HGNC
Ensembl
ENSG00000135919
NCBI Gene
Aliases
GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI, nexin
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07093Glia-derived nexin3982Ensembl, GeneID, HGNC

Source UniProt

Patents87

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463221P07093Espacenet
EP 4650780 A22025-11-191686P07093Espacenet
JP 2025147176 A2025-10-0612087P07093Espacenet
JP 2025529142 A2025-09-047688P07093Espacenet
US 12371689 B22025-07-297688P07093Espacenet
JP 2025517970 A2025-06-121686P07093Espacenet
JP 2025032204 A2025-03-1135477P07093Espacenet
JP 2025028160 A2025-02-2812087P07093Espacenet
KR 1020250010750 A2025-01-2112087P07093Espacenet
EP 4461818 A22024-11-1335477P07093Espacenet

1 to 10 of 87

See all 87 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,163

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSERPINE2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant62025
T32HL007427SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES62025
T32CA009054A Training Program for Interdisciplinary Cancer Research52025
P30CA010815Consolidated Basic Cancer Research Program42025
UL1TR002345Washington University Institute of Clinical and Translational Sciences42025
ZICAG000616Analysis of complex biological systems by high-throughput genomic technologies42025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment32025
R01HL055374Unraveling the role of tPA in the neurovascular unit32025
T32CA009531Training Program in the Biology of Cancer32025

1 to 10 of 1,163Source NIH's project files

See all 1,163 nih grants

Papers2,089

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cancer-associated fibroblast-derived interleukin-6 as a key driver of epithelial-mesenchymal transition and metastasis in oral squamous cell carcinoma.J Dent Sci202642688644PubTator, text miningPubMed
DeepPNI: a language- and graph-based model for mutation-driven protein-nucleic acid binding energetics.Nucleic Acids Res202642605800PubTator, text miningPubMed
[A Case of Adenocarcinoma of Esophagogastric Junction with CY1 in Which Staging Laparoscopy Was Useful in Deciding Whether to Continue Chemotherapy].Gan To Kagaku Ryoho202642551930PubTator, text miningPubMed
The Biological Basis of the Merlin CP-GEP Assay: Integrin Signaling and Early Metastatic Competence in Cutaneous Melanoma.Int J Dermatol202642545806PubTator, text miningPubMed
Membrane proteomic profiling to identify candidate therapy targets for glioblastoma infiltration.Neurooncol Adv202642534387PubTator, text miningPubMed
CircSERPINE2 Induces Platinum Resistance in Ovarian Cancer via the miR-513a-5p/miR-526b-3p/SEMA7A Axis.Recent Pat Anticancer Drug Discov202642515881PubTator, text miningPubMed
snRNA-seq of acral melanoma reveals heterogeneity and identifies novel progression marker and cancer-associated fibroblasts subpopulation.NPJ Precis Oncol202642469458PubTator, text miningPubMed
A three-protein serum risk score for predicting immunotherapy response and prognosis in non-small cell lung cancer.Int J Clin Exp Pathol202642466209PubTator, text miningPubMed
The clinicopathological significance of METTL3/SERPINE2 immunoexpression in urothelial carcinoma of the urinary bladder.Pol J Pathol202642458973PubTator, text miningPubMed
Low Margin-To-Depth of Invasion Ratio Plus pN1 Predict Poor Prognosis in Oral Cancer Without Adverse Features.Oral Dis202642458716PubTator, text miningPubMed

1 to 10 of 2,089

See all 2,089 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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