Gene · 5270
SERPINE2: serpin family E member 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SERPINE2: serpin family E member 2. Genes, record 5270. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5270
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P07093 | Glia-derived nexin | 398 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents87
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63221 | P07093 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1686 | P07093 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 12087 | P07093 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7688 | P07093 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7688 | P07093 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1686 | P07093 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 35477 | P07093 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 12087 | P07093 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 12087 | P07093 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 35477 | P07093 | Espacenet |
1 to 10 of 87
See all 87 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,163
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SERPINE2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| T32HL007427 | SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES | 6 | 2025 |
| T32CA009054 | A Training Program for Interdisciplinary Cancer Research | 5 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 4 | 2025 |
| UL1TR002345 | Washington University Institute of Clinical and Translational Sciences | 4 | 2025 |
| ZICAG000616 | Analysis of complex biological systems by high-throughput genomic technologies | 4 | 2025 |
| P30ES007033 | University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment | 3 | 2025 |
| R01HL055374 | Unraveling the role of tPA in the neurovascular unit | 3 | 2025 |
| T32CA009531 | Training Program in the Biology of Cancer | 3 | 2025 |
1 to 10 of 1,163Source NIH's project files
See all 1,163 nih grantsPapers2,089
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Cancer-associated fibroblast-derived interleukin-6 as a key driver of epithelial-mesenchymal transition and metastasis in oral squamous cell carcinoma. | J Dent Sci | 2026 | 42688644 | PubTator, text mining | PubMed |
| DeepPNI: a language- and graph-based model for mutation-driven protein-nucleic acid binding energetics. | Nucleic Acids Res | 2026 | 42605800 | PubTator, text mining | PubMed |
| [A Case of Adenocarcinoma of Esophagogastric Junction with CY1 in Which Staging Laparoscopy Was Useful in Deciding Whether to Continue Chemotherapy]. | Gan To Kagaku Ryoho | 2026 | 42551930 | PubTator, text mining | PubMed |
| The Biological Basis of the Merlin CP-GEP Assay: Integrin Signaling and Early Metastatic Competence in Cutaneous Melanoma. | Int J Dermatol | 2026 | 42545806 | PubTator, text mining | PubMed |
| Membrane proteomic profiling to identify candidate therapy targets for glioblastoma infiltration. | Neurooncol Adv | 2026 | 42534387 | PubTator, text mining | PubMed |
| CircSERPINE2 Induces Platinum Resistance in Ovarian Cancer via the miR-513a-5p/miR-526b-3p/SEMA7A Axis. | Recent Pat Anticancer Drug Discov | 2026 | 42515881 | PubTator, text mining | PubMed |
| snRNA-seq of acral melanoma reveals heterogeneity and identifies novel progression marker and cancer-associated fibroblasts subpopulation. | NPJ Precis Oncol | 2026 | 42469458 | PubTator, text mining | PubMed |
| A three-protein serum risk score for predicting immunotherapy response and prognosis in non-small cell lung cancer. | Int J Clin Exp Pathol | 2026 | 42466209 | PubTator, text mining | PubMed |
| The clinicopathological significance of METTL3/SERPINE2 immunoexpression in urothelial carcinoma of the urinary bladder. | Pol J Pathol | 2026 | 42458973 | PubTator, text mining | PubMed |
| Low Margin-To-Depth of Invasion Ratio Plus pN1 Predict Poor Prognosis in Oral Cancer Without Adverse Features. | Oral Dis | 2026 | 42458716 | PubTator, text mining | PubMed |
1 to 10 of 2,089
See all 2,089 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5270
GET https://conductscience.org/api/genes/v1/5270/patents?page=2