Gene · 5277
PIGA: phosphatidylinositol glycan anchor biosynthesis class A
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PIGA: phosphatidylinositol glycan anchor biosynthesis class A. Genes, record 5277. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5277
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P37287 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit A | 484 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents35
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 57593 | P37287 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 10315 | P37287 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3470 | P37287 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3470 | P37287 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 10315 | P37287 | Espacenet |
| WO 2025093745 A1 | 2025-05-08 | 269 | P37287 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 33415 | P37287 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 33416 | P37287 | Espacenet |
| JP 2024178415 A | 2024-12-24 | 473 | P37287 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 33415 | P37287 | Espacenet |
1 to 10 of 35
See all 35 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants598
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PIGA papers | Newest fiscal year |
|---|---|---|---|
| ZIAHL002315 | Immune Pathophysiology of Aplastic Anemia and Immunosuppressive Treatments | 18 | 2025 |
| T32HL007525 | Training Program in Hematology | 9 | 2025 |
| R01DK078244 | Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes | 5 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 4 | 2025 |
| R01AI165570 | Investigating polymeric antibody assembly, structure, function and therapeutic potential | 4 | 2025 |
| R01DK099551 | New Congenital Disorders of Glycosylation: Therapy and Models | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| P01CA066996 | Development of Novel Therapeutic Strategies in Human Leukemias | 3 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 3 | 2025 |
| R35GM124780 | Investigating the impact of genetic variation on the ER stress response, protein folding, and disease | 3 | 2025 |
1 to 10 of 598Source NIH's project files
See all 598 nih grantsPapers1,372
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Breakthrough Hemolysis in Paroxysmal Nocturnal Hemoglobinuria: Mechanistic Insights and Management Strategies. | Transfusion | 2026 | 42755219 | PubTator, text mining | PubMed |
| Patterns of clonal hematopoiesis in aplastic anemia under immunosuppressive therapy. | Leukemia | 2026 | 42693160 | PubTator, text mining | PubMed |
| A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG. | PLoS Genet | 2026 | 42672098 | PubTator, text mining | PubMed |
| Does the 2-test in vitro genotoxicity battery of Ames plus in vitro micronucleus tests detect relevant substances that induce gene mutations in vivo? | Mutat Res Genet Toxicol Environ Mutagen | 2026 | 42580787 | PubTator, text mining | PubMed |
| Haemolytic Anaemia; Beyond Sickle Cell Anaemia: A Case Series of Patients With Paroxysmal Nocturnal Haemoglobinuria in Kenya. | Case Rep Hematol | 2026 | 42529569 | PubTator, text mining | PubMed |
| Investigation of Ethylene Oxide Genotoxicity Dose-Response to Inform Cancer Risk Assessment. | Environ Mol Mutagen | 2026 | 42454540 | PubTator, text mining | PubMed |
| Concurrent Loss of PIGA and ZRSR2 in a Patient With Paroxysmal Nocturnal Hemoglobinuria and Myelodysplastic Neoplasm. | Int J Lab Hematol | 2026 | 42432858 | PubTator, text mining | PubMed |
| Clonal Selection and Evolution after Treatment of Severe Aplastic Anemia. | NEJM Evid | 2026 | 42047559 | PubTator, text mining | PubMed |
| A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG. | bioRxiv | 2026 | 42039650 | PubTator, text mining | PubMed |
| Imputing causality and clonal dynamics from single-cell transcriptomics in paroxysmal nocturnal hemoglobinuria. | Leukemia | 2026 | 42020783 | PubTator, text mining | PubMed |
1 to 10 of 1,372
See all 1,372 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5277
GET https://conductscience.org/api/genes/v1/5277/patents?page=2