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Gene · 5277

PIGA: phosphatidylinositol glycan anchor biosynthesis class A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PIGA: phosphatidylinositol glycan anchor biosynthesis class A. Genes, record 5277. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5277

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Gene

Symbol
PIGA
HGNC
Name
phosphatidylinositol glycan anchor biosynthesis class A
HGNC
NCBI Gene ID
5277
NCBI Gene
HGNC ID
HGNC:8957
HGNC
Ensembl
ENSG00000165195
NCBI Gene
Aliases
GPI3, MCAHS2, NEDEPH, PIG-A, PNH1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P37287Phosphatidylinositol N-acetylglucosaminyltransferase subunit A4840Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457593P37287Espacenet
EP 4650780 A22025-11-1910315P37287Espacenet
JP 2025529142 A2025-09-043470P37287Espacenet
US 12371689 B22025-07-293470P37287Espacenet
JP 2025517970 A2025-06-1210315P37287Espacenet
WO 2025093745 A12025-05-08269P37287Espacenet
JP 2025032204 A2025-03-1133415P37287Espacenet
JP 2025032204 A2025-03-1133416P37287Espacenet
JP 2024178415 A2024-12-24473P37287Espacenet
EP 4461818 A22024-11-1333415P37287Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants598

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePIGA papersNewest fiscal year
ZIAHL002315Immune Pathophysiology of Aplastic Anemia and Immunosuppressive Treatments182025
T32HL007525Training Program in Hematology92025
R01DK078244Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes52025
P30CA006973Regional Oncology Research Center42025
R01AI165570Investigating polymeric antibody assembly, structure, function and therapeutic potential42025
R01DK099551New Congenital Disorders of Glycosylation: Therapy and Models42025
UL1TR001863Yale Clinical and Translational Science Award42025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias32025
P30CA016520Abramson Cancer Center Support Grant32025
R35GM124780Investigating the impact of genetic variation on the ER stress response, protein folding, and disease32025

1 to 10 of 598Source NIH's project files

See all 598 nih grants

Papers1,372

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Breakthrough Hemolysis in Paroxysmal Nocturnal Hemoglobinuria: Mechanistic Insights and Management Strategies.Transfusion202642755219PubTator, text miningPubMed
Patterns of clonal hematopoiesis in aplastic anemia under immunosuppressive therapy.Leukemia202642693160PubTator, text miningPubMed
A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG.PLoS Genet202642672098PubTator, text miningPubMed
Does the 2-test in vitro genotoxicity battery of Ames plus in vitro micronucleus tests detect relevant substances that induce gene mutations in vivo?Mutat Res Genet Toxicol Environ Mutagen202642580787PubTator, text miningPubMed
Haemolytic Anaemia; Beyond Sickle Cell Anaemia: A Case Series of Patients With Paroxysmal Nocturnal Haemoglobinuria in Kenya.Case Rep Hematol202642529569PubTator, text miningPubMed
Investigation of Ethylene Oxide Genotoxicity Dose-Response to Inform Cancer Risk Assessment.Environ Mol Mutagen202642454540PubTator, text miningPubMed
Concurrent Loss of PIGA and ZRSR2 in a Patient With Paroxysmal Nocturnal Hemoglobinuria and Myelodysplastic Neoplasm.Int J Lab Hematol202642432858PubTator, text miningPubMed
Clonal Selection and Evolution after Treatment of Severe Aplastic Anemia.NEJM Evid202642047559PubTator, text miningPubMed
A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG.bioRxiv202642039650PubTator, text miningPubMed
Imputing causality and clonal dynamics from single-cell transcriptomics in paroxysmal nocturnal hemoglobinuria.Leukemia202642020783PubTator, text miningPubMed

1 to 10 of 1,372

See all 1,372 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5277

GET https://conductscience.org/api/genes/v1/5277/patents?page=2