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PIK3CA: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

1 protein, 211 patents, 37 drugs, 395 trials, 11,384 NIH grants and 39,468 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPIK3CAHGNC
Namephosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaHGNC
NCBI Gene ID5290NCBI Gene
HGNC IDHGNC:8975HGNC
EnsemblENSG00000121879NCBI Gene
AliasesCCM4, CLAPO, CLOVE, CWS5, HMH, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alphaNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P42336Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform1,068135Ensembl, GeneID, HGNCUniProt

Patents 211

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026172356 A12026-08-202P42336Espacenet
WO 2026143130 A12026-07-021P42336Espacenet
JP 2026509320 A2026-03-181P42336Espacenet
WO 2026013052 A12026-01-151P42336Espacenet
WO 2025247348 A12025-12-041P42336Espacenet
JP 2025538147 A2025-11-261P42336Espacenet
EP 4650780 A22025-11-192277P42336Espacenet
WO 2025231327 A12025-11-061P42336Espacenet
EP 4641201 A22025-10-291850P42336Espacenet
JP 2025535066 A2025-10-221P42336Espacenet

Drugs 37

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALPELISIBCHEMBL2396661PI3-kinase p110-alpha subunit inhibitorINHIBITORChEMBL
APITOLISIBCHEMBL1922094PI3-kinase class I inhibitorINHIBITORChEMBL
AZD-6482CHEMBL2165191PI3-kinase class I inhibitorINHIBITORChEMBL
BAY-1082439CHEMBL3644672PI3-kinase p110-alpha subunit inhibitorINHIBITORChEMBL
BGT-226CHEMBL3545096PI3-kinase class I inhibitorINHIBITORChEMBL
BGT-226 FREE BASECHEMBL3218578PI3-kinase class I inhibitorINHIBITORChEMBL
BUPARLISIBCHEMBL2017974PI3-kinase class I inhibitorINHIBITORChEMBL
COPANLISIBCHEMBL3218576PI3-kinase p110-alpha subunit inhibitorINHIBITORChEMBL
COPANLISIB HYDROCHLORIDECHEMBL3545068PI3-kinase p110-alpha subunit inhibitorINHIBITORChEMBL
DACTOLISIBCHEMBL1879463PI3-kinase class I inhibitorINHIBITORChEMBL

Trials 395

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07558733SERABELISIBPHASE1/PHASE2ClinicalTrials.gov
NCT07543822ALPELISIBPHASE2ClinicalTrials.gov
NCT07543250INAVOLISIBClinicalTrials.gov
NCT07522697INAVOLISIBPHASE2ClinicalTrials.gov
NCT07447076PAXALISIBPHASE2ClinicalTrials.gov
NCT07441512INAVOLISIBPHASE2ClinicalTrials.gov
NCT07405801INAVOLISIBPHASE2ClinicalTrials.gov
NCT07391215PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT07368998INAVOLISIBPHASE2ClinicalTrials.gov
NCT07347600INAVOLISIBClinicalTrials.gov

NIH grants 11384

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant8232,025NIH's project files
P30CA016672Cancer Center Support Grant7142,025NIH's project files
P30CA006973Regional Oncology Research Center1372,025NIH's project files
P30CA068485Cancer Center Support Grant1012,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award942,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant902,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant612,025NIH's project files
P30CA016058Cancer Center Support Grant592,025NIH's project files
P30CA016086Cancer Center Support Grant592,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant582,025NIH's project files

Papers 39468

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827142PubTator, text miningPubMed
42825943PubTator, text miningPubMed
42823758PubTator, text miningPubMed
42823566PubTator, text miningPubMed
42820858PubTator, text miningPubMed
42820048PubTator, text miningPubMed
42817923PubTator, text miningPubMed
42817873PubTator, text miningPubMed
42817222PubTator, text miningPubMed
42814223PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license