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PIM1: Pim-1 proto-oncogene, serine/threonine kinase

1 protein, 74 patents, 3 drugs, 9 trials, 2,767 NIH grants and 4,952 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPIM1HGNC
NamePim-1 proto-oncogene, serine/threonine kinaseHGNC
NCBI Gene ID5292NCBI Gene
HGNC IDHGNC:8986HGNC
EnsemblENSG00000137193NCBI Gene
AliasesPIMNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P11309Serine/threonine-protein kinase pim-1313192Ensembl, GeneID, HGNCUniProt

Patents 74

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458073P11309Espacenet
EP 4650780 A22025-11-199324P11309Espacenet
EP 4641201 A22025-10-299561P11309Espacenet
JP 2025517969 A2025-06-129561P11309Espacenet
JP 2025517970 A2025-06-129324P11309Espacenet
EP 4487869 A22025-01-08398P11309Espacenet
JP 2024509935 A2024-03-0536P11309Espacenet
KR 1020240027895 A2024-03-04586P11309Espacenet
JP 2023036863 A2023-03-14586P11309Espacenet
US 11446398 B22022-09-2063773P11309Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZD-1208CHEMBL3545423Serine/threonine-protein kinase PIM inhibitorINHIBITORChEMBL
LGH-447CHEMBL3651966Serine/threonine-protein kinase PIM inhibitorINHIBITORChEMBL
SGI-1776CHEMBL1952329Serine/threonine-protein kinase PIM inhibitorINHIBITORChEMBL

Trials 9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02370706LGH-447PHASE1ClinicalTrials.gov
NCT02160951LGH-447PHASE1ClinicalTrials.gov
NCT02144038LGH-447PHASE1ClinicalTrials.gov
NCT02078609LGH-447PHASE1ClinicalTrials.gov
NCT01588548AZD-1208PHASE12015-08-19ClinicalTrials.gov
NCT01489722AZD-1208PHASE1ClinicalTrials.gov
NCT01456689LGH-447PHASE1ClinicalTrials.gov
NCT01239108SGI-1776PHASE1ClinicalTrials.gov
NCT00848601SGI-1776PHASE1ClinicalTrials.gov

NIH grants 2767

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant382,025NIH's project files
P30CA016672Cancer Center Support Grant382,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant202,025NIH's project files
P30CA138313Medical University of South Carolina - Cancer Center Support Grant142,025NIH's project files
P30CA016058Cancer Center Support Grant132,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center102,025NIH's project files
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT102,025NIH's project files
P30CA033572Cancer Center Support Grant82,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)72,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant72,025NIH's project files

Papers 4952

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822254PubTator, text miningPubMed
42816331PubTator, text miningPubMed
42814612PubTator, text miningPubMed
42814177PubTator, text miningPubMed
42806053PubTator, text miningPubMed
42769123PubTator, text miningPubMed
42754234PubTator, text miningPubMed
42738605PubTator, text miningPubMed
42723345PubTator, text miningPubMed
42695015PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license