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PIK3CG: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

1 protein, 138 patents, 34 drugs, 268 trials, 5,123 NIH grants and 9,720 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPIK3CGHGNC
Namephosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaHGNC
NCBI Gene ID5294NCBI Gene
HGNC IDHGNC:8978HGNC
EnsemblENSG00000105851NCBI Gene
AliasesIMD97, PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3KNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P48736Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform1,102107Ensembl, GeneID, HGNCUniProt

Patents 138

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4661970 A12025-12-1762174P48736Espacenet
EP 4641201 A22025-10-297672P48736Espacenet
JP 2025147176 A2025-10-0614665P48736Espacenet
JP 2025147176 A2025-10-0614711P48736Espacenet
JP 2025517969 A2025-06-127672P48736Espacenet
WO 2025101914 A12025-05-152P48736Espacenet
JP 2025028160 A2025-02-2814665P48736Espacenet
JP 2025028160 A2025-02-2814711P48736Espacenet
KR 1020250010750 A2025-01-2114665P48736Espacenet
KR 1020250010750 A2025-01-2114711P48736Espacenet

Drugs 34

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APITOLISIBCHEMBL1922094PI3-kinase class I inhibitorINHIBITORChEMBL
AZD-6482CHEMBL2165191PI3-kinase class I inhibitorINHIBITORChEMBL
BGT-226CHEMBL3545096PI3-kinase class I inhibitorINHIBITORChEMBL
BGT-226 FREE BASECHEMBL3218578PI3-kinase class I inhibitorINHIBITORChEMBL
BUPARLISIBCHEMBL2017974PI3-kinase class I inhibitorINHIBITORChEMBL
CAL-263CHEMBL3545247PI3-kinase p110-gamma subunit inhibitorINHIBITORChEMBL
DACTOLISIBCHEMBL1879463PI3-kinase class I inhibitorINHIBITORChEMBL
DS-7423CHEMBL3545248PI3-kinase class I inhibitorINHIBITORChEMBL
DUVELISIBCHEMBL3039502PI3-kinase p110-gamma subunit inhibitorINHIBITORChEMBL
DUVELISIB MONOHYDRATECHEMBL5315125PI3-kinase p110-gamma subunit inhibitorINHIBITORChEMBL

Trials 268

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07447076PAXALISIBPHASE2ClinicalTrials.gov
NCT07439211EGANELISIBPHASE1ClinicalTrials.gov
NCT07391215PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT07293403DUVELISIBPHASE2ClinicalTrials.gov
NCT07287202PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT07001384DUVELISIBPHASE1ClinicalTrials.gov
NCT06810778DUVELISIBPHASE1/PHASE2ClinicalTrials.gov
NCT06757634GEDATOLISIBPHASE3ClinicalTrials.gov
NCT06533761EGANELISIBPHASE1ClinicalTrials.gov
NCT06208657PAXALISIBPHASE1/PHASE2ClinicalTrials.gov

NIH grants 5123

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant892,025NIH's project files
P30CA008748Cancer Center Support Grant792,025NIH's project files
P30CA016058Cancer Center Support Grant182,025NIH's project files
P30CA006973Regional Oncology Research Center132,025NIH's project files
P30CA068485Cancer Center Support Grant132,025NIH's project files
R01CA167426Role of PI3Kgamma in Tumor Progression and Metastasis132,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award102,025NIH's project files
P30CA016042Cancer Center Support Grant92,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant82,025NIH's project files
P30CA016086Cancer Center Support Grant82,025NIH's project files

Papers 9720

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42816667PubTator, text miningPubMed
42794945PubTator, text miningPubMed
42738248PubTator, text miningPubMed
42724825PubTator, text miningPubMed
42702742PubTator, text miningPubMed
42653865PubTator, text miningPubMed
42635598PubTator, text miningPubMed
42618717PubTator, text miningPubMed
42617420PubTator, text miningPubMed
42614945PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license