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PIK3R1: phosphoinositide-3-kinase regulatory subunit 1

1 protein, 103 patents, 28 drugs, 203 trials, 23,190 NIH grants and 65,600 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPIK3R1HGNC
Namephosphoinositide-3-kinase regulatory subunit 1HGNC
NCBI Gene ID5295NCBI Gene
HGNC IDHGNC:8979HGNC
EnsemblENSG00000145675NCBI Gene
AliasesAGM7, GRB1, IMD36, p85, p85-ALPHA, p85alphaNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P27986Phosphatidylinositol 3-kinase regulatory subunit alpha724105Ensembl, GeneID, HGNCUniProt

Patents 103

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1915087P27986Espacenet
EP 4641201 A22025-10-2917932P27986Espacenet
EP 4641202 A22025-10-297390P27986Espacenet
JP 2025517969 A2025-06-1217932P27986Espacenet
JP 2025517970 A2025-06-1215087P27986Espacenet
JP 2025032204 A2025-03-1133453P27986Espacenet
JP 2025032204 A2025-03-1133454P27986Espacenet
KR 1020250017231 A2025-02-047390P27986Espacenet
EP 4461818 A22024-11-1333453P27986Espacenet
EP 4461818 A22024-11-1333454P27986Espacenet

Drugs 28

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APITOLISIBCHEMBL1922094PI3-kinase class I inhibitorINHIBITORChEMBL
AZD-6482CHEMBL2165191PI3-kinase class I inhibitorINHIBITORChEMBL
BGT-226CHEMBL3545096PI3-kinase class I inhibitorINHIBITORChEMBL
BGT-226 FREE BASECHEMBL3218578PI3-kinase class I inhibitorINHIBITORChEMBL
BUPARLISIBCHEMBL2017974PI3-kinase class I inhibitorINHIBITORChEMBL
DACTOLISIBCHEMBL1879463PI3-kinase class I inhibitorINHIBITORChEMBL
DS-7423CHEMBL3545248PI3-kinase class I inhibitorINHIBITORChEMBL
GEDATOLISIBCHEMBL592445PI3-kinase class I inhibitorINHIBITORChEMBL
GSK-1059615CHEMBL3544966PI3-kinase class I inhibitorINHIBITORChEMBL
IZORLISIBCHEMBL1684984PI3-kinase class I inhibitorINHIBITORChEMBL

Trials 203

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07447076PAXALISIBPHASE2ClinicalTrials.gov
NCT07391215PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT07287202PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT06757634GEDATOLISIBPHASE3ClinicalTrials.gov
NCT06208657PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT06190899GEDATOLISIBPHASE1/PHASE2ClinicalTrials.gov
NCT05501886GEDATOLISIBPHASE3ClinicalTrials.gov
NCT05183204PAXALISIBPHASE2ClinicalTrials.gov
NCT05009992PAXALISIBPHASE2ClinicalTrials.gov
NCT04906096PAXALISIBPHASE2ClinicalTrials.gov

NIH grants 23190

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant5352,025NIH's project files
P30CA008748Cancer Center Support Grant3902,025NIH's project files
P30CA068485Cancer Center Support Grant1012,025NIH's project files
P30CA006973Regional Oncology Research Center872,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)682,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award672,025NIH's project files
P30CA016058Cancer Center Support Grant642,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant562,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant552,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program542,025NIH's project files

Papers 65600

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822966PubTator, text miningPubMed
42821811PubTator, text miningPubMed
42821795PubTator, text miningPubMed
42821792PubTator, text miningPubMed
42820858PubTator, text miningPubMed
42814929PubTator, text miningPubMed
42812104PubTator, text miningPubMed
42808410PubTator, text miningPubMed
42806054PubTator, text miningPubMed
42789045PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license