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PIK3R2: phosphoinositide-3-kinase regulatory subunit 2

1 protein, 32 patents, 28 drugs, 203 trials, 3,400 NIH grants and 5,722 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPIK3R2HGNC
Namephosphoinositide-3-kinase regulatory subunit 2HGNC
NCBI Gene ID5296NCBI Gene
HGNC IDHGNC:8980HGNC
EnsemblENSG00000105647NCBI Gene
AliasesMPPH, MPPH1, P85B, p85, p85-BETA, p85betaNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O00459Phosphatidylinositol 3-kinase regulatory subunit beta7288Ensembl, GeneID, HGNCUniProt

Patents 32

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19545O00459Espacenet
EP 4641201 A22025-10-29384O00459Espacenet
JP 2025517969 A2025-06-12384O00459Espacenet
JP 2025517970 A2025-06-12545O00459Espacenet
JP 2024123008 A2024-09-107631O00459Espacenet
US 11446398 B22022-09-2062516O00459Espacenet
US 11446398 B22022-09-2063156O00459Espacenet
US 11446398 B22022-09-2063159O00459Espacenet
JP 2022524081 A2022-04-27165487O00459Espacenet
JP 2022524081 A2022-04-27166127O00459Espacenet

Drugs 28

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APITOLISIBCHEMBL1922094PI3-kinase class I inhibitorINHIBITORChEMBL
AZD-6482CHEMBL2165191PI3-kinase class I inhibitorINHIBITORChEMBL
BGT-226CHEMBL3545096PI3-kinase class I inhibitorINHIBITORChEMBL
BGT-226 FREE BASECHEMBL3218578PI3-kinase class I inhibitorINHIBITORChEMBL
BUPARLISIBCHEMBL2017974PI3-kinase class I inhibitorINHIBITORChEMBL
DACTOLISIBCHEMBL1879463PI3-kinase class I inhibitorINHIBITORChEMBL
DS-7423CHEMBL3545248PI3-kinase class I inhibitorINHIBITORChEMBL
GEDATOLISIBCHEMBL592445PI3-kinase class I inhibitorINHIBITORChEMBL
GSK-1059615CHEMBL3544966PI3-kinase class I inhibitorINHIBITORChEMBL
IZORLISIBCHEMBL1684984PI3-kinase class I inhibitorINHIBITORChEMBL

Trials 203

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07447076PAXALISIBPHASE2ClinicalTrials.gov
NCT07391215PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT07287202PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT06757634GEDATOLISIBPHASE3ClinicalTrials.gov
NCT06208657PAXALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT06190899GEDATOLISIBPHASE1/PHASE2ClinicalTrials.gov
NCT05501886GEDATOLISIBPHASE3ClinicalTrials.gov
NCT05183204PAXALISIBPHASE2ClinicalTrials.gov
NCT05009992PAXALISIBPHASE2ClinicalTrials.gov
NCT04906096PAXALISIBPHASE2ClinicalTrials.gov

NIH grants 3400

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant662,025NIH's project files
P30CA008748Cancer Center Support Grant412,025NIH's project files
P30CA068485Cancer Center Support Grant192,025NIH's project files
P30DK036836Diabetes Research Center152,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program112,025NIH's project files
P30CA016058Cancer Center Support Grant112,025NIH's project files
R01NS058721ACC: Callosal Agenesis as a Window into Common Neurodevelopmental Disorders112,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes102,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant102,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant102,025NIH's project files

Papers 5722

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826079PubTator, text miningPubMed
42814813PubTator, text miningPubMed
42724360PubTator, text miningPubMed
42688965PubTator, text miningPubMed
42662823PubTator, text miningPubMed
42604788PubTator, text miningPubMed
42594169PubTator, text miningPubMed
42584803PubTator, text miningPubMed
42575983PubTator, text miningPubMed
42515581PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license