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Gene · 5300

PIN1: peptidylprolyl cis/trans isomerase, NIMA-interacting 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PIN1: peptidylprolyl cis/trans isomerase, NIMA-interacting 1. Genes, record 5300. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5300

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Gene

Symbol
PIN1
HGNC
Name
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
HGNC
NCBI Gene ID
5300
NCBI Gene
HGNC ID
HGNC:8988
HGNC
Ensembl
ENSG00000127445
NCBI Gene
Aliases
DOD, UBL5, dod
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13526Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1163190Ensembl, GeneID, HGNC

Source UniProt

Patents78

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4805736 A22026-09-1615Q13526Espacenet
EP 4650780 A22025-11-191232Q13526Espacenet
JP 2025517970 A2025-06-121232Q13526Espacenet
EP 4487869 A22025-01-08400Q13526Espacenet
JP 2024123008 A2024-09-107577Q13526Espacenet
US 12023385 B22024-07-0228Q13526Espacenet
KR 1020240027895 A2024-03-04588Q13526Espacenet
US 11898154 B22024-02-1355Q13526Espacenet
JP 2023036863 A2023-03-14588Q13526Espacenet
EP 4119552 A12023-01-1842Q13526Espacenet

1 to 10 of 78

See all 78 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,100

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePIN1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant302025
P30CA008748Cancer Center Support Grant122025
P30CA046934University of Colorado Cancer Center Support Grant92025
P30CA014195Cancer Center Support Grant (CCSG)62025
P30CA047904Cancer Center Support Grant62025
P30CA021765Cancer Center Support Grant (CCSG)52025
P30CA030199Cancer Center Support Grant (CCSG)52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P50CA168504Dana Farber/Harvard Cancer Center Specialized Program of Research Excellence in Breast Cancer52025
R35GM122459Development of cell-permeable peptides and proteins52025

1 to 10 of 2,100Source NIH's project files

See all 2,100 nih grants

Papers3,752

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Pin1-cis P-tau Axis: A Key Common Early Pathogenic Driver, Biomarker and Therapeutic Target Across Neurodegenerative, Traumatic, and Vascular Cognitive Disorders.Cells202642782751PubTator, text miningPubMed
Nx3 Is a Z-Disk Structural and Signaling Hub That Is Reduced in Heart Failure.Circ Res202642717863PubTator, text miningPubMed
Beyond β-Adrenergic Receptor Brake: Compartment-Selective GRK2 Programs from Heart Failure to Cardio-Oncology.Kinases Phosphatases202642614945PubTator, text miningPubMed
Female chronic social defeat stress (femCSDS) maps synaptic, bioenergetic and metabolic proteome remodeling in the nucleus accumbens (NAc).Front Syst Biol202642614171PubTator, text miningPubMed
PIN1 enhances SUMOylation of YAP1 and inhibits ferroptosis via autophagy-dependent degradation of ACSL4 in cervical cancer.Cell Death Discov202642481442PubTator, text miningPubMed
Pin1 in cancer: Signaling mechanisms, structural basis and advances in inhibitor development.Eur J Med Chem202642480355PubTator, text miningPubMed
PIN1 inhibits ferroptosis in gastric cancer cells by regulating the CPEB1‑GPX4 pathway.Oncol Rep202642438262PubTator, text miningPubMed
Structure-Based Discovery of (E)- and (Z)-4-Oxobut-2-enoate Derivatives as Novel Covalent Pin1 Inhibitors with Antitumor Activity.J Med Chem202642388100PubTator, text miningPubMed
Proline-directed phosphorylation and prolyl isomerization oppose each other to regulate PSD-95 ubiquitination and excitatory synaptic plasticity.Front Mol Neurosci202642381736PubTator, text miningPubMed
Pin1 targets phosphorylated NCOA4 for K29/K48-linked ubiquitination to suppress ferritinophagy and ferroptosis in anaplastic thyroid cancer.Cell Death Dis202642380121PubTator, text miningPubMed

1 to 10 of 3,752

See all 3,752 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5300

GET https://conductscience.org/api/genes/v1/5300/patents?page=2