Gene · 5300
PIN1: peptidylprolyl cis/trans isomerase, NIMA-interacting 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PIN1: peptidylprolyl cis/trans isomerase, NIMA-interacting 1. Genes, record 5300. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5300
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 163 | 190 | Ensembl, GeneID, HGNC |
Source UniProt
Patents78
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4805736 A2 | 2026-09-16 | 15 | Q13526 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1232 | Q13526 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1232 | Q13526 | Espacenet |
| EP 4487869 A2 | 2025-01-08 | 400 | Q13526 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7577 | Q13526 | Espacenet |
| US 12023385 B2 | 2024-07-02 | 28 | Q13526 | Espacenet |
| KR 1020240027895 A | 2024-03-04 | 588 | Q13526 | Espacenet |
| US 11898154 B2 | 2024-02-13 | 55 | Q13526 | Espacenet |
| JP 2023036863 A | 2023-03-14 | 588 | Q13526 | Espacenet |
| EP 4119552 A1 | 2023-01-18 | 42 | Q13526 | Espacenet |
1 to 10 of 78
See all 78 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,100
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PIN1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 30 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 9 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 6 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 5 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 5 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| P50CA168504 | Dana Farber/Harvard Cancer Center Specialized Program of Research Excellence in Breast Cancer | 5 | 2025 |
| R35GM122459 | Development of cell-permeable peptides and proteins | 5 | 2025 |
1 to 10 of 2,100Source NIH's project files
See all 2,100 nih grantsPapers3,752
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The Pin1-cis P-tau Axis: A Key Common Early Pathogenic Driver, Biomarker and Therapeutic Target Across Neurodegenerative, Traumatic, and Vascular Cognitive Disorders. | Cells | 2026 | 42782751 | PubTator, text mining | PubMed |
| Nx3 Is a Z-Disk Structural and Signaling Hub That Is Reduced in Heart Failure. | Circ Res | 2026 | 42717863 | PubTator, text mining | PubMed |
| Beyond β-Adrenergic Receptor Brake: Compartment-Selective GRK2 Programs from Heart Failure to Cardio-Oncology. | Kinases Phosphatases | 2026 | 42614945 | PubTator, text mining | PubMed |
| Female chronic social defeat stress (femCSDS) maps synaptic, bioenergetic and metabolic proteome remodeling in the nucleus accumbens (NAc). | Front Syst Biol | 2026 | 42614171 | PubTator, text mining | PubMed |
| PIN1 enhances SUMOylation of YAP1 and inhibits ferroptosis via autophagy-dependent degradation of ACSL4 in cervical cancer. | Cell Death Discov | 2026 | 42481442 | PubTator, text mining | PubMed |
| Pin1 in cancer: Signaling mechanisms, structural basis and advances in inhibitor development. | Eur J Med Chem | 2026 | 42480355 | PubTator, text mining | PubMed |
| PIN1 inhibits ferroptosis in gastric cancer cells by regulating the CPEB1‑GPX4 pathway. | Oncol Rep | 2026 | 42438262 | PubTator, text mining | PubMed |
| Structure-Based Discovery of (E)- and (Z)-4-Oxobut-2-enoate Derivatives as Novel Covalent Pin1 Inhibitors with Antitumor Activity. | J Med Chem | 2026 | 42388100 | PubTator, text mining | PubMed |
| Proline-directed phosphorylation and prolyl isomerization oppose each other to regulate PSD-95 ubiquitination and excitatory synaptic plasticity. | Front Mol Neurosci | 2026 | 42381736 | PubTator, text mining | PubMed |
| Pin1 targets phosphorylated NCOA4 for K29/K48-linked ubiquitination to suppress ferritinophagy and ferroptosis in anaplastic thyroid cancer. | Cell Death Dis | 2026 | 42380121 | PubTator, text mining | PubMed |
1 to 10 of 3,752
See all 3,752 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5300
GET https://conductscience.org/api/genes/v1/5300/patents?page=2