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Gene · 5307

PITX1: paired like homeodomain 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PITX1: paired like homeodomain 1. Genes, record 5307. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5307

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Gene

Symbol
PITX1
HGNC
Name
paired like homeodomain 1
HGNC
NCBI Gene ID
5307
NCBI Gene
HGNC ID
HGNC:9004
HGNC
Ensembl
ENSG00000069011
NCBI Gene
Aliases
BFT, CCF, POTX, PTX1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P78337Pituitary homeobox 13140Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456919P78337Espacenet
JP 2026004568 A2026-01-1456921P78337Espacenet
JP 2025147176 A2025-10-0615490P78337Espacenet
JP 2025028160 A2025-02-2815490P78337Espacenet
KR 1020250010750 A2025-01-2115490P78337Espacenet
JP 2024109657 A2024-08-1415329P78337Espacenet
US 11446398 B22022-09-2060955P78337Espacenet
US 11446398 B22022-09-2060958P78337Espacenet
JP 2022524081 A2022-04-27163926P78337Espacenet
JP 2022524081 A2022-04-27163929P78337Espacenet

1 to 10 of 22

See all 22 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,009

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePITX1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant62025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
P50HD103525WASHINGTON UNIVERSITY INTELLECTUAL AND DEVELOPMENTAL DISABILITIES RESEARCH CENTER42025
T32HG000040University of Michigan Training Program in Genomic Science42025
P01HD084387Developmental Mechanisms of Human Idiopathic Scoliosis32025
P30CA016672Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P30DK058404Molecular and Cellular Basis for Digestive Diseases32025
P30DK063491Diabetes Research Center (DRC)32025
U01CA167551Colon Cancer Family Registry Cohort32025

1 to 10 of 1,009Source NIH's project files

See all 1,009 nih grants

Papers1,358

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Fibroblast proliferative capacity predicts prognosis in idiopathic pulmonary fibrosis and identifies PITX1 as a growth-associated gene.Sarcoidosis Vasc Diffuse Lung Dis202642813314PubTator, text miningPubMed
Coarse-graining analysis for non-invasive, label-free, and quantitative evaluation of undulating motion in cultured oral mucosa epithelial cell sheets.Regen Ther202642733435PubTator, text miningPubMed
PITX1 facilitates the proliferation and tumorigenesis of NSCLC cells via potentiating PHB2-mediated AKT activity.Cell Signal202642731741PubTator, text miningPubMed
Generation of Functional GnRH-Responsive Pituitary-like Organoids from Ovine Embryonic Stem Cells.Cells202642587770PubTator, text miningPubMed
Phase-dependent dynamics of circulating cell-free mitochondrial DNA reflect distinct immunometabolic states.Rev Inst Med Trop Sao Paulo202642525119PubTator, text miningPubMed
LAMA5 links extracellular matrix organization to a candidate WNT-associated endothelial signaling niche during human chondrogenesis.iScience202642472097PubTator, text miningPubMed
Prenatal Diagnosis of PITX1-Related Limb Malformations in the Second Trimester.Prenat Diagn202642333653PubTator, text miningPubMed
Isoliquiritigenin Impedes Breast Cancer Progression through PITX1-PFKP-Mediated Glycolysis Reprogramming.Oncol Res202642065039PubTator, text miningPubMed
Cell-free mitochondrial DNA and microRNA-137 for early diagnosis of preeclampsia.Front Cardiovasc Med202641993856PubTator, text miningPubMed
Mitochondrial signals in the bloodstream: Peripheral signature of mitochondrial dysfunction in mental health. A systematic review.Neurosci Biobehav Rev202641921723PubTator, text miningPubMed

1 to 10 of 1,358

See all 1,358 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5307

GET https://conductscience.org/api/genes/v1/5307/patents?page=2