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Gene · 5308

PITX2: paired like homeodomain 2

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. PITX2: paired like homeodomain 2. Genes, record 5308. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/5308

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
PITX2
HGNC
Name
paired like homeodomain 2
HGNC
NCBI Gene ID
5308
NCBI Gene
HGNC ID
HGNC:9005
HGNC
Ensembl
ENSG00000164093
NCBI Gene
Aliases
ARP1, ASGD4, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99697Pituitary homeobox 23173Ensembl, GeneID, HGNC

Source UniProt

Patents59

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456924Q99697Espacenet
JP 2026004568 A2026-01-1456926Q99697Espacenet
EP 4650780 A22025-11-197112Q99697Espacenet
EP 4641201 A22025-10-297012Q99697Espacenet
JP 2025147176 A2025-10-0615491Q99697Espacenet
JP 2025517969 A2025-06-127012Q99697Espacenet
JP 2025517970 A2025-06-127112Q99697Espacenet
JP 2025028160 A2025-02-2815491Q99697Espacenet
KR 1020250010750 A2025-01-2115491Q99697Espacenet
JP 2024151104 A2024-10-2431Q99697Espacenet

1 to 10 of 59

See all 59 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants3,178

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL402025
P30DK063491Diabetes Research Center (DRC)182025
P30EY007003University of Michigan Vision Research Center152025
R01NS017950Precursors of Stroke Incidence and Prognosis142025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal132025
R01HL118761Pitx2 in atrial fibrillation112025
ZIAAI000738Control of G-protein Signaling: Role of RGSs102025
P30CA008748Cancer Center Support Grant82025
P30CA016672Cancer Center Support Grant82025
R01DA036596Regulation of Neuronal GPCR Signaling82025

1 to 10 of 3,178Source NIH's project files

See all 3,178 nih grants

Papers4,092

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818334PubTator, text miningPubMed
42805970PubTator, text miningPubMed
42765034PubTator, text miningPubMed
42762433PubTator, text miningPubMed
42755888PubTator, text miningPubMed
42728069PubTator, text miningPubMed
42702404PubTator, text miningPubMed
42667103PubTator, text miningPubMed
42648599PubTator, text miningPubMed
42439392PubTator, text miningPubMed

1 to 10 of 4,092

See all 4,092 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5308

GET https://conductscience.org/api/genes/v1/5308/patents?page=2