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PKD2: polycystin 2, transient receptor potential cation channel

1 protein, 56 patents, 0 drugs, 0 trials, 2,938 NIH grants and 5,803 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPKD2HGNC
Namepolycystin 2, transient receptor potential cation channelHGNC
NCBI Gene ID5311NCBI Gene
HGNC IDHGNC:9009HGNC
EnsemblENSG00000118762NCBI Gene
AliasesAPKD2, PC2, PKD4, Pc-2, TRPP2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13563Polycystin-296831Ensembl, GeneID, HGNCUniProt

Patents 56

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4719492 A22026-04-0812Q13563Espacenet
JP 2026004568 A2026-01-1458403Q13563Espacenet
EP 4650780 A22025-11-19944Q13563Espacenet
EP 4641201 A22025-10-29664Q13563Espacenet
JP 2025529142 A2025-09-043498Q13563Espacenet
JP 2025528887 A2025-09-025Q13563Espacenet
US 12371689 B22025-07-293498Q13563Espacenet
KR 1020250112316 A2025-07-235Q13563Espacenet
JP 2025517969 A2025-06-12664Q13563Espacenet
JP 2025517970 A2025-06-12944Q13563Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2938

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01DK058816ADPKD: Disease Spectrum & Genotype-Phenotype Correlations592,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award212,025NIH's project files
P30DK084567Mayo Center for Cell Signaling in Gastroenterology202,025NIH's project files
ZIADK075042The role of PKD proteins in regulating tubular morphology182,025NIH's project files
P30DK034989Yale Liver Center162,025NIH's project files
R01DK059418Polycystins, cilia, and extracellular vesicles in C. elegans162,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase152,025NIH's project files
R01GM060992Intraflagellar Transport Proteins in Mice152,025NIH's project files
R01DK059597Investigation of common disease mechanisms in nonsyndromic and syndromic PKD132,025NIH's project files
U54DK126126Kansas PKD Research and Translation Core Center132,025NIH's project files

Papers 5803

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42814551PubTator, text miningPubMed
42809393PubTator, text miningPubMed
42801810PubTator, text miningPubMed
42796377PubTator, text miningPubMed
42794351PubTator, text miningPubMed
42779593PubTator, text miningPubMed
42772449PubTator, text miningPubMed
42751568PubTator, text miningPubMed
42741939PubTator, text miningPubMed
42741279PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license