ConductScience.org, home

Gene · 5318

PKP2: plakophilin 2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. PKP2: plakophilin 2. Genes, record 5318. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5318

On this page

Gene

Symbol
PKP2
HGNC
Name
plakophilin 2
HGNC
NCBI Gene ID
5318
NCBI Gene
HGNC ID
HGNC:9024
HGNC
Ensembl
ENSG00000057294
NCBI Gene
Aliases
ARVD9
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99959Plakophilin-28811Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026116276 A2026-07-094Q99959Espacenet
JP 2026502465 A2026-01-232Q99959Espacenet
JP 2026004568 A2026-01-1458098Q99959Espacenet
EP 4646218 A12025-11-122Q99959Espacenet
EP 4641201 A22025-10-2970Q99959Espacenet
JP 2025517969 A2025-06-1270Q99959Espacenet
WO 2024220722 A12024-10-2442Q99959Espacenet
JP 2024514110 A2024-03-2830Q99959Espacenet
JP 2024512483 A2024-03-197Q99959Espacenet
US 11883506 B22024-01-302Q99959Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,132

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePKP2 papersNewest fiscal year
R01AR041836Function of Desmoglein 1/Pemphigus Foliaceus Antigen212025
R01AR043380Desmoplakin Assembly and Function in Epidermis172025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center112025
R01HL132401Mechanisms and Therapeutic Targeting of DNA Damage in Dilated Cardiomyopathy Caused by LMNA Mutations72025
T32HL007227Pathophysiology of Myocardial Disease62025
T32HL007572Research Methods in Pediatric Cardiovascular Disease62025
P30CA016672Cancer Center Support Grant52025
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL52025
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling52025
R35HL160840Molecular Atlas of the Cardiac Intercalated Disc52025

1 to 10 of 1,132Source NIH's project files

See all 1,132 nih grants

Papers2,073

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Construction and characterization of a cardiac organoid ARVC disease model with its application in gene therapy targeting PKP2.Genes Dis202742733516PubTator, text miningPubMed
Acute effects of physical exercise in patients with arrhythmogenic cardiomyopathy harboring plakophilin-2 variants.Heart Rhythm202642785606PubTator, text miningPubMed
A two-gene prognostic model for lung adenocarcinoma using summary-data-based Mendelian randomization analysis and Cox proportional hazards regression.Future Sci OA202642758874PubTator, text miningPubMed
Flecainide reduces exercise-induced arrhythmic burden in PKP2-related arrhythmogenic cardiomyopathy.Europace202642748463PubTator, text miningPubMed
Biventricular arrhythmogenic cardiomyopathy due to a PKP2 mutation with severe heart failure and multifocal thromboembolism as the clinically apparent presentation: a case report.Eur Heart J Case Rep202642712920PubTator, text miningPubMed
Advanced imaging and multi-omics to characterize cardiomyocyte ageing and its electrocardiographic imprint in PKP2 arrhythmogenic cardiomyopathy.J Physiol202642681832PubTator, text miningPubMed
CDKN3, PKP2, ADM, MS4A1, FAM83A, and DKK1 Define a Posttranslational Modification (PTM)-Associated Prognostic Model for Lung Adenocarcinoma.Hum Mutat202642638932PubTator, text miningPubMed
Assessment of isochromosome 12p supports that pagetoid involvement of the rete testis represents spread of germ cell neoplasia in-situ.Hum Pathol202642628849PubTator, text miningPubMed
Exercise-induced ventricular arrhythmias: a marker of risk in arrhythmogenic cardiomyopathy.Heart202642567694PubTator, text miningPubMed
A Review of Cardiomyopathy Gene Variants as Drivers of Early-Onset Atrial Fibrillation: Linking Genotype to Phenotype in Precision Medicine.Eur Heart J Qual Care Clin Outcomes202642483946PubTator, text miningPubMed

1 to 10 of 2,073

See all 2,073 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5318

GET https://conductscience.org/api/genes/v1/5318/patents?page=2