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Gene · 5320

PLA2G2A: phospholipase A2 group IIA

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PLA2G2A: phospholipase A2 group IIA. Genes, record 5320. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5320

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Gene

Symbol
PLA2G2A
HGNC
Name
phospholipase A2 group IIA
HGNC
NCBI Gene ID
5320
NCBI Gene
HGNC ID
HGNC:9031
HGNC
Ensembl
ENSG00000188257
NCBI Gene
Aliases
MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P14555Phospholipase A2, membrane associated14417Ensembl, GeneID, HGNC

Source UniProt

Patents104

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4774000 A12026-07-151P14555Espacenet
JP 2026026192 A2026-02-1626P14555Espacenet
EP 4650780 A22025-11-199577P14555Espacenet
JP 2025147176 A2025-10-0610465P14555Espacenet
JP 2025147176 A2025-10-0610466P14555Espacenet
JP 2025529142 A2025-09-047363P14555Espacenet
WO 2025169993 A2025-08-146P14555Espacenet
US 12371689 B22025-07-297363P14555Espacenet
JP 2025517970 A2025-06-129577P14555Espacenet
JP 2025028160 A2025-02-2810465P14555Espacenet

1 to 10 of 104

See all 104 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
VARESPLADIBCHEMBL148674Phospholipase A2 group IIA inhibitorINHIBITORChEMBL
VARESPLADIB METHYLCHEMBL2105659Phospholipase A2 group IIA inhibitorINHIBITORChEMBL

Trials5

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04969991VARESPLADIBPHASE22025-05-15ClinicalTrials.gov
NCT01130246VARESPLADIB METHYLPHASE3ClinicalTrials.gov
NCT00743925VARESPLADIB METHYLPHASE2ClinicalTrials.gov
NCT00525954VARESPLADIB METHYLPHASE2ClinicalTrials.gov
NCT00455546VARESPLADIB METHYLPHASE2ClinicalTrials.gov

NIH grants1,438

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePLA2G2A papersNewest fiscal year
R35GM139641Action of Lipolytic Enzymes82025
P30CA016672Cancer Center Support Grant52025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
K24AI130263Immunopathology of Indirect Airway Hyperresponsiveness in Asthma32025
P30CA016058Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P30CA093373Cancer Center Support Grant P3032025
P30ES013508Center of Excellence in Environmental Toxicology32025
P40OD010960Viper Resource Grant at Texas A&M University-Kingsville32025
R01DK039773Mechanisms of Ischemic Kidney Injury and Repair32025

1 to 10 of 1,438Source NIH's project files

See all 1,438 nih grants

Papers3,288

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of Domain Formation During sPLA2 Activity by Biophotonics.Methods Mol Biol202742778863PubTator, text miningPubMed
Clusterin expression and germinal center morphometry help distinguish idiopathic multicentric castleman disease from select lymphadenopathies.Front Immunol202642824315PubTator, text miningPubMed
A systemic neuroendocrine immune axis in breast cancer revealed by MMD regularized cross tissue latent alignment across four independent cohorts.Comput Biol Med202642762681PubTator, text miningPubMed
Camphorquinone-induced phospholipase A2 and cyclooxygenase -2 expression and its roles in 8-isoprostane and prostaglandin E2 production of human dental pulp cells.J Dent Sci202642688640PubTator, text miningPubMed
Varespladib for snakebite envenoming: insights from therapeutic development and clinical trials.Expert Opin Investig Drugs202642685248PubTator, text miningPubMed
Preoperative Serum Alkaline Phosphatase Predicts Arteriovenous Fistula Maturation Failure.Kidney Int Rep202642569269PubTator, text miningPubMed
The Sind krait (Bungarus sindanus): Insights into natural history, venom toxicology, neurotoxic mechanisms, and future directions.Chem Biol Interact202642562291PubTator, text miningPubMed
Ramulus Mori alkaloids (SZ-A) sensitize triple-negative breast cancer to cisplatin via PLA2G2A-mediated ceramide metabolism.Chin J Nat Med202642476660PubTator, text miningPubMed
Comparison of the efficacy of varespladib and coral snake antivenom against the activities of the Amazon coral snake (Micrurus spixii) venom.Toxicon202642419684PubTator, text miningPubMed
Mutation detection in women diagnosed with endometrial cancer: a next-generation sequencing analysis.Mol Cell Oncol202642376597PubTator, text miningPubMed

1 to 10 of 3,288

See all 3,288 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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