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PLAT: plasminogen activator, tissue type

1 protein, 254 patents, 8 drugs, 264 trials, 8,043 NIH grants and 32,774 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPLATHGNC
Nameplasminogen activator, tissue typeHGNC
NCBI Gene ID5327NCBI Gene
HGNC IDHGNC:9051HGNC
EnsemblENSG00000104368NCBI Gene
AliasesT-PA, TPANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00750Tissue-type plasminogen activator56211Ensembl, GeneID, HGNCUniProt

Patents 254

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4780482 A12026-07-291P00750Espacenet
EP 4770664 A12026-07-083P00750Espacenet
JP 2026520004 A2026-06-191P00750Espacenet
EP 4713445 A22026-03-251P00750Espacenet
WO 2025257350 A12025-12-18268P00750Espacenet
EP 4650780 A22025-11-19483P00750Espacenet
JP 2025169942 A2025-11-141211P00750Espacenet
JP 2025169942 A2025-11-141214P00750Espacenet
EP 4640849 A22025-10-2955P00750Espacenet
EP 4641201 A22025-10-29340P00750Espacenet

Drugs 8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALTEPLASECHEMBL1201593Tissue-type plasminogen activator exogenous proteinEXOGENOUS PROTEINChEMBL
AMINOCAPROIC ACIDCHEMBL1046Tissue-type plasminogen activator inhibitorINHIBITORChEMBL
DUTEPLASECHEMBL2108375Tissue-type plasminogen activator exogenous proteinEXOGENOUS PROTEINChEMBL
LANOTEPLASECHEMBL2108499Tissue-type plasminogen activator exogenous proteinEXOGENOUS PROTEINChEMBL
MONTEPLASECHEMBL2108426Tissue-type plasminogen activator exogenous proteinEXOGENOUS PROTEINChEMBL
PAMITEPLASECHEMBL2108072Tissue-type plasminogen activator exogenous proteinEXOGENOUS PROTEINChEMBL
RETEPLASECHEMBL2107885Tissue-type plasminogen activator exogenous proteinEXOGENOUS PROTEINChEMBL
TENECTEPLASECHEMBL2108791Tissue-type plasminogen activator exogenous proteinEXOGENOUS PROTEINChEMBL

Trials 264

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07606807TENECTEPLASEPHASE3ClinicalTrials.gov
NCT07603700ALTEPLASEClinicalTrials.gov
NCT07603440TENECTEPLASEPHASE3ClinicalTrials.gov
NCT07519889ALTEPLASEClinicalTrials.gov
NCT07519889TENECTEPLASEClinicalTrials.gov
NCT07476898TENECTEPLASEPHASE3ClinicalTrials.gov
NCT07475936TENECTEPLASEClinicalTrials.gov
NCT07471256TENECTEPLASEPHASE3ClinicalTrials.gov
NCT07432373ALTEPLASEClinicalTrials.gov
NCT07375966TENECTEPLASEPHASE2ClinicalTrials.gov

NIH grants 8043

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
T32GM008315Mechanisms of Trauma-Induced Coagulopathy602,025NIH's project files
R01HL055374Unraveling the role of tPA in the neurovascular unit422,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award302,025NIH's project files
U54GM104942West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health232,025NIH's project files
ZIANS003043Novel Insights Into Cerebral Ischemic Pathophysiology In Humans222,025NIH's project files
I01BX000347Cerebral Arteriole Structure/Function in Diabetic Ischemic Brain Injury192,025NIH's project files
P30CA008748Cancer Center Support Grant152,025NIH's project files
U01NS086872NIH StrokeNet National Clinical Coordinating Center (NCC)142,025NIH's project files
P30CA016672Cancer Center Support Grant132,025NIH's project files
P51OD011132Emory National Primate Research Center132,025NIH's project files

Papers 32774

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822011PubTator, text miningPubMed
42811903PubTator, text miningPubMed
42811433PubTator, text miningPubMed
42801661PubTator, text miningPubMed
42788987PubTator, text miningPubMed
42785651PubTator, text miningPubMed
42782234PubTator, text miningPubMed
42777900PubTator, text miningPubMed
42772781PubTator, text miningPubMed
42772058PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license