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PLAU: plasminogen activator, urokinase

1 protein, 32 patents, 1 drug, 16 trials, 6,100 NIH grants and 22,244 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPLAUHGNC
Nameplasminogen activator, urokinaseHGNC
NCBI Gene ID5328NCBI Gene
HGNC IDHGNC:9052HGNC
EnsemblENSG00000122861NCBI Gene
AliasesATF, BDPLT5, QPD, UPA, URK, u-PANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00749Urokinase-type plasminogen activator431156Ensembl, GeneID, HGNCUniProt

Patents 32

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2025262265 A12025-12-2623P00749Espacenet
WO 2025257350 A12025-12-18267P00749Espacenet
EP 4650780 A22025-11-199170P00749Espacenet
WO 2025225410 A2025-10-309P00749Espacenet
EP 4640849 A22025-10-291367P00749Espacenet
EP 4641201 A22025-10-299417P00749Espacenet
EP 4641203 A22025-10-29272P00749Espacenet
JP 2025147176 A2025-10-0610492P00749Espacenet
JP 2025519096 A2025-06-241367P00749Espacenet
JP 2025517967 A2025-06-12272P00749Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
UROKINASECHEMBL1201420Urokinase-type plasminogen activator exogenous proteinEXOGENOUS PROTEINChEMBL

Trials 16

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603700UROKINASEClinicalTrials.gov
NCT07047326UROKINASEClinicalTrials.gov
NCT04792944UROKINASEClinicalTrials.gov
NCT04420351UROKINASEPHASE3ClinicalTrials.gov
NCT03716375UROKINASEClinicalTrials.gov
NCT03578822UROKINASEPHASE3ClinicalTrials.gov
NCT03541668UROKINASEPHASE3ClinicalTrials.gov
NCT03108833UROKINASEPHASE2ClinicalTrials.gov
NCT02854592UROKINASEClinicalTrials.gov
NCT02414802UROKINASEClinicalTrials.gov

NIH grants 6100

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant562,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT232,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant222,025NIH's project files
R01HL055374Unraveling the role of tPA in the neurovascular unit222,025NIH's project files
ZIADE000699Cell surface proteolysis in development, tissue repair, and malignancy202,025NIH's project files
P30CA008748Cancer Center Support Grant162,025NIH's project files
ZIAAI000929Vaccines and Therapeutics for Anthrax152,025NIH's project files
I01BX003441TPA Protects the Synapse in the Iscemic Brain132,025NIH's project files
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant112,025NIH's project files
P51OD011132Emory National Primate Research Center112,025NIH's project files

Papers 22244

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826661PubTator, text miningPubMed
42815788PubTator, text miningPubMed
42806572PubTator, text miningPubMed
42804753PubTator, text miningPubMed
42793067PubTator, text miningPubMed
42782790PubTator, text miningPubMed
42774172PubTator, text miningPubMed
42772524PubTator, text miningPubMed
42769801PubTator, text miningPubMed
42768826PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license