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Gene · 53335

BCL11A: BCL11 transcription factor A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BCL11A: BCL11 transcription factor A. Genes, record 53335. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/53335

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Gene

Symbol
BCL11A
HGNC
Name
BCL11 transcription factor A
HGNC
NCBI Gene ID
53335
NCBI Gene
HGNC ID
HGNC:13221
HGNC
Ensembl
ENSG00000119866
NCBI Gene
Aliases
BCL11A-L, BCL11A-S, BCL11A-XL, CTIP1, DILOS, EVI9, HBFQTL5, SMARCM1, ZNF856
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H165BCL11 transcription factor A83517Ensembl, GeneID, HGNC

Source UniProt

Patents55

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1438654Q9H165Espacenet
JP 2025164846 A2025-10-3038Q9H165Espacenet
EP 4641201 A22025-10-2925074Q9H165Espacenet
JP 2025147176 A2025-10-0614790Q9H165Espacenet
JP 2025134087 A2025-09-16245Q9H165Espacenet
WO 2025141078 A12025-07-031Q9H165Espacenet
EP 4577658 A12025-07-026Q9H165Espacenet
JP 2025517969 A2025-06-1225074Q9H165Espacenet
JP 2025062604 A2025-04-148435Q9H165Espacenet
JP 2025032204 A2025-03-1125130Q9H165Espacenet

1 to 10 of 55

See all 55 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
EXAGAMGLOGENE AUTOTEMCELCHEMBL5095474B-cell lymphoma/leukemia 11A gene editing negative modulatorGENE EDITING NEGATIVE MODULATOR

Source ChEMBL

Trials7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07577817EXAGAMGLOGENE AUTOTEMCELEARLY_PHASE1ClinicalTrials.gov
NCT05951205EXAGAMGLOGENE AUTOTEMCELPHASE3ClinicalTrials.gov
NCT05477563EXAGAMGLOGENE AUTOTEMCELPHASE3ClinicalTrials.gov
NCT05356195EXAGAMGLOGENE AUTOTEMCELPHASE3ClinicalTrials.gov
NCT05329649EXAGAMGLOGENE AUTOTEMCELPHASE3ClinicalTrials.gov
NCT04208529EXAGAMGLOGENE AUTOTEMCELPHASE3ClinicalTrials.gov
NCT03745287EXAGAMGLOGENE AUTOTEMCELPHASE2/PHASE3ClinicalTrials.gov

NIH grants2,687

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBCL11A papersNewest fiscal year
R01DK103794Systematic Genetic Dissection of Human Erythropoiesis212025
U54DK106829Stem Cell and Transplantation Biology182025
R01HL119479Regulation of Hemoglobin Switching172025
RM1HG009490Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease152025
P30CA021765Cancer Center Support Grant (CCSG)142025
P30CA016672Cancer Center Support Grant122025
P30CA008748Cancer Center Support Grant112025
R35GM118062Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics102025
R01HL156647Base editing and prime editing for sickle cell disease92025
R35GM134744Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and Mechanisms82025

1 to 10 of 2,687Source NIH's project files

See all 2,687 nih grants

Papers3,029

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Human genetics implicates a BACH2-NRF2 axis in fetal haemoglobin activation.Nature202642816612PubTator, text miningPubMed
Clinical translation of CRISPR-Cas9 therapeutics in cancer and inherited genetic disorders.Front Genome Ed202642787623PubTator, text miningPubMed
CRISPR-Based Mediated Reactivation of Fetal Hemoglobin as a Therapeutic Strategy for Hemoglobinopathies: Evidence from Preclinical to Clinical Trials in Sickle Cell Disease and β-Thalassemia.Hemoglobin202642755327PubTator, text miningPubMed
SaCas9 and AsCas12a Ultra Enable Highly Efficient and Specific Gene Editing in Hematopoietic Stem and Progenitor Cells.Cell Biomater202642746631PubTator, text miningPubMed
A transcription factor-focused CRISPR screen identifies SKI as a BCL11A-independent repressor of ζ-globin.J Genet Genomics202642710656PubTator, text miningPubMed
Molecular genetics analysis of genes BCL11A, HBS1L-MYB, and HBG2 variants association in thalassemic children.Per Med202642708502PubTator, text miningPubMed
Global genetic modifiers of fetal hemoglobin in sickle cell disease: Systematic review and meta-analysis.iScience202642657270PubTator, text miningPubMed
Genetic Evidence for Unified Airway Disease: Shared Epithelial and Immune Architecture Across Major Airway Diseases.Int J Mol Sci202642653451PubTator, text miningPubMed
Long Non-Coding RNAs and Circular RNAs in the Pathobiology of T-Cell Lymphoma.Cancers (Basel)202642649850PubTator, text miningPubMed
Engineered lipid nanoparticles for in vivo and durable editing of haematopoietic stem cells within humanized mice.Nat Biomed Eng202642557300PubTator, text miningPubMed

1 to 10 of 3,029

See all 3,029 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/53335

GET https://conductscience.org/api/genes/v1/53335/patents?page=2