Gene · 53335
BCL11A: BCL11 transcription factor A
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. BCL11A: BCL11 transcription factor A. Genes, record 53335. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/53335
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9H165 | BCL11 transcription factor A | 835 | 17 | Ensembl, GeneID, HGNC |
Source UniProt
Patents55
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 38654 | Q9H165 | Espacenet |
| JP 2025164846 A | 2025-10-30 | 38 | Q9H165 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 25074 | Q9H165 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 14790 | Q9H165 | Espacenet |
| JP 2025134087 A | 2025-09-16 | 245 | Q9H165 | Espacenet |
| WO 2025141078 A1 | 2025-07-03 | 1 | Q9H165 | Espacenet |
| EP 4577658 A1 | 2025-07-02 | 6 | Q9H165 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 25074 | Q9H165 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 8435 | Q9H165 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 25130 | Q9H165 | Espacenet |
1 to 10 of 55
See all 55 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| EXAGAMGLOGENE AUTOTEMCEL | CHEMBL5095474 | B-cell lymphoma/leukemia 11A gene editing negative modulator | GENE EDITING NEGATIVE MODULATOR |
Source ChEMBL
Trials7
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07577817 | EXAGAMGLOGENE AUTOTEMCEL | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT05951205 | EXAGAMGLOGENE AUTOTEMCEL | PHASE3 | ClinicalTrials.gov | |
| NCT05477563 | EXAGAMGLOGENE AUTOTEMCEL | PHASE3 | ClinicalTrials.gov | |
| NCT05356195 | EXAGAMGLOGENE AUTOTEMCEL | PHASE3 | ClinicalTrials.gov | |
| NCT05329649 | EXAGAMGLOGENE AUTOTEMCEL | PHASE3 | ClinicalTrials.gov | |
| NCT04208529 | EXAGAMGLOGENE AUTOTEMCEL | PHASE3 | ClinicalTrials.gov | |
| NCT03745287 | EXAGAMGLOGENE AUTOTEMCEL | PHASE2/PHASE3 | ClinicalTrials.gov |
NIH grants2,687
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | BCL11A papers | Newest fiscal year |
|---|---|---|---|
| R01DK103794 | Systematic Genetic Dissection of Human Erythropoiesis | 21 | 2025 |
| U54DK106829 | Stem Cell and Transplantation Biology | 18 | 2025 |
| R01HL119479 | Regulation of Hemoglobin Switching | 17 | 2025 |
| RM1HG009490 | Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease | 15 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 14 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 12 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 11 | 2025 |
| R35GM118062 | Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics | 10 | 2025 |
| R01HL156647 | Base editing and prime editing for sickle cell disease | 9 | 2025 |
| R35GM134744 | Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and Mechanisms | 8 | 2025 |
1 to 10 of 2,687Source NIH's project files
See all 2,687 nih grantsPapers3,029
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Human genetics implicates a BACH2-NRF2 axis in fetal haemoglobin activation. | Nature | 2026 | 42816612 | PubTator, text mining | PubMed |
| Clinical translation of CRISPR-Cas9 therapeutics in cancer and inherited genetic disorders. | Front Genome Ed | 2026 | 42787623 | PubTator, text mining | PubMed |
| CRISPR-Based Mediated Reactivation of Fetal Hemoglobin as a Therapeutic Strategy for Hemoglobinopathies: Evidence from Preclinical to Clinical Trials in Sickle Cell Disease and β-Thalassemia. | Hemoglobin | 2026 | 42755327 | PubTator, text mining | PubMed |
| SaCas9 and AsCas12a Ultra Enable Highly Efficient and Specific Gene Editing in Hematopoietic Stem and Progenitor Cells. | Cell Biomater | 2026 | 42746631 | PubTator, text mining | PubMed |
| A transcription factor-focused CRISPR screen identifies SKI as a BCL11A-independent repressor of ζ-globin. | J Genet Genomics | 2026 | 42710656 | PubTator, text mining | PubMed |
| Molecular genetics analysis of genes BCL11A, HBS1L-MYB, and HBG2 variants association in thalassemic children. | Per Med | 2026 | 42708502 | PubTator, text mining | PubMed |
| Global genetic modifiers of fetal hemoglobin in sickle cell disease: Systematic review and meta-analysis. | iScience | 2026 | 42657270 | PubTator, text mining | PubMed |
| Genetic Evidence for Unified Airway Disease: Shared Epithelial and Immune Architecture Across Major Airway Diseases. | Int J Mol Sci | 2026 | 42653451 | PubTator, text mining | PubMed |
| Long Non-Coding RNAs and Circular RNAs in the Pathobiology of T-Cell Lymphoma. | Cancers (Basel) | 2026 | 42649850 | PubTator, text mining | PubMed |
| Engineered lipid nanoparticles for in vivo and durable editing of haematopoietic stem cells within humanized mice. | Nat Biomed Eng | 2026 | 42557300 | PubTator, text mining | PubMed |
1 to 10 of 3,029
See all 3,029 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/53335
GET https://conductscience.org/api/genes/v1/53335/patents?page=2