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Gene · 53345

TM6SF2: transmembrane 6 superfamily member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TM6SF2: transmembrane 6 superfamily member 2. Genes, record 53345. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/53345

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Gene

Symbol
TM6SF2
HGNC
Name
transmembrane 6 superfamily member 2
HGNC
NCBI Gene ID
53345
NCBI Gene
HGNC ID
HGNC:11861
HGNC
Ensembl
ENSG00000213996
NCBI Gene
Aliases
Lpr4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9BZW4Transmembrane 6 superfamily member 23770Ensembl, GeneID, HGNC

Source UniProt

Patents15

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026151930 A12026-07-16319Q9BZW4Espacenet
JP 2026004568 A2026-01-1467734Q9BZW4Espacenet
EP 4640849 A22025-10-291636Q9BZW4Espacenet
EP 4641201 A22025-10-2911078Q9BZW4Espacenet
JP 2025529142 A2025-09-044698Q9BZW4Espacenet
US 12371689 B22025-07-294698Q9BZW4Espacenet
JP 2025519096 A2025-06-241636Q9BZW4Espacenet
JP 2025517969 A2025-06-1211078Q9BZW4Espacenet
US 11446398 B22022-09-2090587Q9BZW4Espacenet
US 11400116 B22022-08-02366Q9BZW4Espacenet

1 to 10 of 15

See all 15 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants915

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTM6SF2 papersNewest fiscal year
U01DK061734Clinical Research on Nonalcoholic Fatty Liver Disease192025
P30DK120515San Diego Digestive Diseases Research Center182025
UL1TR001863Yale Clinical and Translational Science Award132025
P30DK020572Michigan Diabetes Research Center (MDRC)112025
UL1TR001881UCLA Clinical and Translational Science Institute112025
P30DK063491Diabetes Research Center (DRC)102025
U01DK061737Collaborative Clinical Research in Nonalcoholic Steatohepatitis92025
U01DK061738Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)92025
R01DK090066PNPLA3 in Susceptibility and Resistance to Fatty Liver Disease82025
U01DK061732Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Clinical Center-Cleveland site82025

1 to 10 of 915Source NIH's project files

See all 915 nih grants

Papers1,658

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Subtyping metabolic dysfunction-associated steatotic liver disease using electronic health record-linked genomic cohorts reveals diverse etiologies and progression.Nat Commun202642823416PubTator, text miningPubMed
PNPLA3 Is Associated With Hepatocellular Carcinoma, While a Five-Variant Polygenic Risk Score Shows Limited Discrimination in Korean Patients With MASLD.J Gastroenterol Hepatol202642802015PubTator, text miningPubMed
A variance QTL approach to uncover gene-fish oil supplement interaction loci for 14 circulating unsaturated fatty acid traits.HGG Adv202642760785PubTator, text miningPubMed
Ultra-rapid progression of MAFLD to cirrhosis and post-transplant steatosis in a patient with a polygenic risk profile.MedScience202642758280PubTator, text miningPubMed
Liver Fibrosis and IRS1 rs2972146 Are Associated With Weight Loss Response After Metabolic Bariatric Surgery.Diabetes Obes Metab202642755140PubTator, text miningPubMed
Risk Factors and Definition of Younger-Onset Metabolic Dysfunction-Associated Steatotic Liver Disease Cirrhosis.Clin Gastroenterol Hepatol202642749101PubTator, text miningPubMed
Structure and function of TM6SF1 reveals role in mTORC1 signaling.Proc Natl Acad Sci U S A202642735304PubTator, text miningPubMed
Ferroptosis, immune activation and MASH-related HCC.Gut202642722415PubTator, text miningPubMed
MBOAT7 rs641738 TT genotype is associated with poorer survival in MASLD-related hepatocellular carcinoma.Front Oncol202642656337PubTator, text miningPubMed
Beyond Fat: Reframing MASLD Through Genetics, Clonal Biology, and Precision Hepatology.Pharmaceuticals (Basel)202642653643PubTator, text miningPubMed

1 to 10 of 1,658

See all 1,658 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/53345

GET https://conductscience.org/api/genes/v1/53345/patents