Gene · 53345
TM6SF2: transmembrane 6 superfamily member 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TM6SF2: transmembrane 6 superfamily member 2. Genes, record 53345. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/53345
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9BZW4 | Transmembrane 6 superfamily member 2 | 377 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents15
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026151930 A1 | 2026-07-16 | 319 | Q9BZW4 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 67734 | Q9BZW4 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1636 | Q9BZW4 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 11078 | Q9BZW4 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4698 | Q9BZW4 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4698 | Q9BZW4 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1636 | Q9BZW4 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 11078 | Q9BZW4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 90587 | Q9BZW4 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 366 | Q9BZW4 | Espacenet |
1 to 10 of 15
See all 15 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants915
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TM6SF2 papers | Newest fiscal year |
|---|---|---|---|
| U01DK061734 | Clinical Research on Nonalcoholic Fatty Liver Disease | 19 | 2025 |
| P30DK120515 | San Diego Digestive Diseases Research Center | 18 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 13 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 11 | 2025 |
| UL1TR001881 | UCLA Clinical and Translational Science Institute | 11 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 10 | 2025 |
| U01DK061737 | Collaborative Clinical Research in Nonalcoholic Steatohepatitis | 9 | 2025 |
| U01DK061738 | Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) | 9 | 2025 |
| R01DK090066 | PNPLA3 in Susceptibility and Resistance to Fatty Liver Disease | 8 | 2025 |
| U01DK061732 | Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Clinical Center-Cleveland site | 8 | 2025 |
1 to 10 of 915Source NIH's project files
See all 915 nih grantsPapers1,658
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Subtyping metabolic dysfunction-associated steatotic liver disease using electronic health record-linked genomic cohorts reveals diverse etiologies and progression. | Nat Commun | 2026 | 42823416 | PubTator, text mining | PubMed |
| PNPLA3 Is Associated With Hepatocellular Carcinoma, While a Five-Variant Polygenic Risk Score Shows Limited Discrimination in Korean Patients With MASLD. | J Gastroenterol Hepatol | 2026 | 42802015 | PubTator, text mining | PubMed |
| A variance QTL approach to uncover gene-fish oil supplement interaction loci for 14 circulating unsaturated fatty acid traits. | HGG Adv | 2026 | 42760785 | PubTator, text mining | PubMed |
| Ultra-rapid progression of MAFLD to cirrhosis and post-transplant steatosis in a patient with a polygenic risk profile. | MedScience | 2026 | 42758280 | PubTator, text mining | PubMed |
| Liver Fibrosis and IRS1 rs2972146 Are Associated With Weight Loss Response After Metabolic Bariatric Surgery. | Diabetes Obes Metab | 2026 | 42755140 | PubTator, text mining | PubMed |
| Risk Factors and Definition of Younger-Onset Metabolic Dysfunction-Associated Steatotic Liver Disease Cirrhosis. | Clin Gastroenterol Hepatol | 2026 | 42749101 | PubTator, text mining | PubMed |
| Structure and function of TM6SF1 reveals role in mTORC1 signaling. | Proc Natl Acad Sci U S A | 2026 | 42735304 | PubTator, text mining | PubMed |
| Ferroptosis, immune activation and MASH-related HCC. | Gut | 2026 | 42722415 | PubTator, text mining | PubMed |
| MBOAT7 rs641738 TT genotype is associated with poorer survival in MASLD-related hepatocellular carcinoma. | Front Oncol | 2026 | 42656337 | PubTator, text mining | PubMed |
| Beyond Fat: Reframing MASLD Through Genetics, Clonal Biology, and Precision Hepatology. | Pharmaceuticals (Basel) | 2026 | 42653643 | PubTator, text mining | PubMed |
1 to 10 of 1,658
See all 1,658 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/53345
GET https://conductscience.org/api/genes/v1/53345/patents