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PLCG1: phospholipase C gamma 1

1 protein, 32 patents, 0 drugs, 0 trials, 3,253 NIH grants and 5,273 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPLCG1HGNC
Namephospholipase C gamma 1HGNC
NCBI Gene ID5335NCBI Gene
HGNC IDHGNC:9065HGNC
EnsemblENSG00000124181NCBI Gene
AliasesIDAA, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P191741-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-11,2906Ensembl, GeneID, HGNCUniProt

Patents 32

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-199285P19174Espacenet
EP 4640849 A22025-10-291387P19174Espacenet
EP 4641201 A22025-10-299513P19174Espacenet
JP 2025519096 A2025-06-241387P19174Espacenet
JP 2025517969 A2025-06-129513P19174Espacenet
JP 2025517970 A2025-06-129285P19174Espacenet
JP 2024123008 A2024-09-107669P19174Espacenet
JP 2024512703 A2024-03-1957P19174Espacenet
KR 1020230166104 A2023-12-0647P19174Espacenet
US 11446398 B22022-09-2063355P19174Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3253

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIABC010304Biochemical Basis of T Cell Activation272,025NIH's project files
P30CA008748Cancer Center Support Grant262,025NIH's project files
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR222,025NIH's project files
P30CA016672Cancer Center Support Grant152,025NIH's project files
R01AI043957Structural Studies of a T cell Specific Tyrosine Kinase142,025NIH's project files
ZICBC010978Confocal Core for the Laboratory of Cellular and Molecular Biology102,025NIH's project files
P30CA068485Cancer Center Support Grant92,025NIH's project files
P30CA086862Cancer Center Support Grant92,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant82,025NIH's project files
T32AI007485Predoctoral Training Program in Immunology82,025NIH's project files

Papers 5273

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818098PubTator, text miningPubMed
42814554PubTator, text miningPubMed
42660817PubTator, text miningPubMed
42659620PubTator, text miningPubMed
42642422PubTator, text miningPubMed
42603278PubTator, text miningPubMed
42542590PubTator, text miningPubMed
42536112PubTator, text miningPubMed
42463032PubTator, text miningPubMed
42334621PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license