Gene · 5336
PLCG2: phospholipase C gamma 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PLCG2: phospholipase C gamma 2. Genes, record 5336. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5336
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P16885 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | 1,265 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents32
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4640849 A2 | 2025-10-29 | 3767 | P16885 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 23291 | P16885 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 3767 | P16885 | Espacenet |
| JP 2025518710 A | 2025-06-19 | 1 | P16885 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 23291 | P16885 | Espacenet |
| JP 2025062601 A | 2025-04-14 | 28 | P16885 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7671 | P16885 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 63365 | P16885 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 166336 | P16885 | Espacenet |
| JP 2022523514 A | 2022-04-25 | 28 | P16885 | Espacenet |
1 to 10 of 32
See all 32 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,705
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PLCG2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 44 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 26 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 22 | 2025 |
| ZIAHL002346 | Tumor microenvironment in CLL and MCL: pathogenesis, targets, and therapy | 20 | 2025 |
| U24AG021886 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) | 19 | 2025 |
| R01CA177292 | Targeted Therapies for Lymphoid Malignancies | 14 | 2025 |
| P30AG066444 | Alzheimer's Disease Research Center | 9 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 9 | 2025 |
| P01AG026276 | Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study | 8 | 2025 |
| P30AG066519 | The Alzheimer's Disease Research Center at the University of California, Irvine | 7 | 2025 |
1 to 10 of 2,705Source NIH's project files
See all 2,705 nih grantsPapers3,625
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Identification of genetic variants associated with monogenic autoinflammatory diseases in patients with Still's disease using next-generation sequencing. | Immunol Res | 2026 | 42821198 | PubTator, text mining | PubMed |
| NFAM1 organizes a lipid raft-restricted DAPP1-PLCG2 module to drive M2-like GAM polarization via Ca²⁺-NFAT1 signaling in glioma. | Neuro Oncol | 2026 | 42820763 | PubTator, text mining | PubMed |
| BTK/BCL2 dual targeting enhances apoptosis in marginal zone lymphoma: preclinical activity of tacabrutideg (BGB-16673) and sonrotoclax. | Haematologica | 2026 | 42817838 | PubTator, text mining | PubMed |
| Gut microbiota-activated PLCγ2 monocytes drive atrial fibrillation. | Nat Commun | 2026 | 42805985 | PubTator, text mining | PubMed |
| A functionally distinct HPA-1a-specific alloantibody associated with fetal/neonatal alloimmune thrombocytopenia that activates platelets via FcγRIIa. | Transfusion | 2026 | 42799830 | PubTator, text mining | PubMed |
| Picropodophyllotoxin Suppresses Factor Xa Activity, Platelet Aggregation, and Arterial Thrombosis. | Biomolecules | 2026 | 42793169 | PubTator, text mining | PubMed |
| Single-Cell RNA Sequencing Reveals Immune Dysregulation and Candidate Drug Targets in Endometriosis. | Cells | 2026 | 42782802 | PubTator, text mining | PubMed |
| ALOX5-Mediated LTA4 Production Enhances PLCG2/IP3 Signaling and Exacerbates Calcification in Human Aortic Valve Interstitial Cells. | Acta Cardiol Sin | 2026 | 42781302 | PubTator, text mining | PubMed |
| A functional prognostic model predicts progression-free survival in patients with relapsed chronic lymphocytic leukemia treated with ibrutinib + venetoclax. | Hemasphere | 2026 | 42757031 | PubTator, text mining | PubMed |
| TREM2 as a central hub of neuroimmune-metabolic crosstalk in central nervous system disorders: from microglial biology to therapeutic targeting. | Front Immunol | 2026 | 42694654 | PubTator, text mining | PubMed |
1 to 10 of 3,625
See all 3,625 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5336
GET https://conductscience.org/api/genes/v1/5336/patents?page=2