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Gene · 5336

PLCG2: phospholipase C gamma 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PLCG2: phospholipase C gamma 2. Genes, record 5336. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5336

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Gene

Symbol
PLCG2
HGNC
Name
phospholipase C gamma 2
HGNC
NCBI Gene ID
5336
NCBI Gene
HGNC ID
HGNC:9066
HGNC
Ensembl
ENSG00000197943
NCBI Gene
Aliases
APLAID, FCAS3, PLC-IV, PLC-gamma-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P168851-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-21,2658Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4640849 A22025-10-293767P16885Espacenet
EP 4641201 A22025-10-2923291P16885Espacenet
JP 2025519096 A2025-06-243767P16885Espacenet
JP 2025518710 A2025-06-191P16885Espacenet
JP 2025517969 A2025-06-1223291P16885Espacenet
JP 2025062601 A2025-04-1428P16885Espacenet
JP 2024123008 A2024-09-107671P16885Espacenet
US 11446398 B22022-09-2063365P16885Espacenet
JP 2022524081 A2022-04-27166336P16885Espacenet
JP 2022523514 A2022-04-2528P16885Espacenet

1 to 10 of 32

See all 32 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,705

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePLCG2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant442025
P30CA008748Cancer Center Support Grant262025
P30CA016058Cancer Center Support Grant222025
ZIAHL002346Tumor microenvironment in CLL and MCL: pathogenesis, targets, and therapy202025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)192025
R01CA177292Targeted Therapies for Lymphoid Malignancies142025
P30AG066444Alzheimer's Disease Research Center92025
P30DK034854Integrated Epithelial and Muscosal Biology92025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study82025
P30AG066519The Alzheimer's Disease Research Center at the University of California, Irvine72025

1 to 10 of 2,705Source NIH's project files

See all 2,705 nih grants

Papers3,625

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of genetic variants associated with monogenic autoinflammatory diseases in patients with Still's disease using next-generation sequencing.Immunol Res202642821198PubTator, text miningPubMed
NFAM1 organizes a lipid raft-restricted DAPP1-PLCG2 module to drive M2-like GAM polarization via Ca²⁺-NFAT1 signaling in glioma.Neuro Oncol202642820763PubTator, text miningPubMed
BTK/BCL2 dual targeting enhances apoptosis in marginal zone lymphoma: preclinical activity of tacabrutideg (BGB-16673) and sonrotoclax.Haematologica202642817838PubTator, text miningPubMed
Gut microbiota-activated PLCγ2 monocytes drive atrial fibrillation.Nat Commun202642805985PubTator, text miningPubMed
A functionally distinct HPA-1a-specific alloantibody associated with fetal/neonatal alloimmune thrombocytopenia that activates platelets via FcγRIIa.Transfusion202642799830PubTator, text miningPubMed
Picropodophyllotoxin Suppresses Factor Xa Activity, Platelet Aggregation, and Arterial Thrombosis.Biomolecules202642793169PubTator, text miningPubMed
Single-Cell RNA Sequencing Reveals Immune Dysregulation and Candidate Drug Targets in Endometriosis.Cells202642782802PubTator, text miningPubMed
ALOX5-Mediated LTA4 Production Enhances PLCG2/IP3 Signaling and Exacerbates Calcification in Human Aortic Valve Interstitial Cells.Acta Cardiol Sin202642781302PubTator, text miningPubMed
A functional prognostic model predicts progression-free survival in patients with relapsed chronic lymphocytic leukemia treated with ibrutinib + venetoclax.Hemasphere202642757031PubTator, text miningPubMed
TREM2 as a central hub of neuroimmune-metabolic crosstalk in central nervous system disorders: from microglial biology to therapeutic targeting.Front Immunol202642694654PubTator, text miningPubMed

1 to 10 of 3,625

See all 3,625 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5336

GET https://conductscience.org/api/genes/v1/5336/patents?page=2