ConductScience.org, home

Gene · 5337

PLD1: phospholipase D1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. PLD1: phospholipase D1. Genes, record 5337. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5337

On this page

Gene

Symbol
PLD1
HGNC
Name
phospholipase D1
HGNC
NCBI Gene ID
5337
NCBI Gene
HGNC ID
HGNC:9067
HGNC
Ensembl
ENSG00000075651
NCBI Gene
Aliases
CVDD, CVDP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13393Phospholipase D11,0742Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4803546 A12026-09-0942Q13393Espacenet
EP 4650780 A22025-11-196763Q13393Espacenet
EP 4641201 A22025-10-296545Q13393Espacenet
JP 2025517969 A2025-06-126545Q13393Espacenet
JP 2025517970 A2025-06-126763Q13393Espacenet
JP 2025032204 A2025-03-1133604Q13393Espacenet
EP 4461818 A22024-11-1333604Q13393Espacenet
JP 2024123008 A2024-09-107674Q13393Espacenet
JP 2023123507 A2023-09-05286Q13393Espacenet
JP 2023058610 A2023-04-2533604Q13393Espacenet

1 to 10 of 34

See all 34 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,119

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePLD1 papersNewest fiscal year
T32CA009592Microenvironmental Influences in Cancer82025
P30CA016672Cancer Center Support Grant62025
R01GM089771Phosphoinositide signaling in autophagy52025
P30CA043703Case Comprehensive Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
T32CA059366Cancer Biology Training Grant42025
P30CA006973Regional Oncology Research Center32025
P30CA013330Cancer Center Support Grant32025
R35GM128666Structure and regulation of lipid metabolism and transport32025
P20GM103436IDeA Networks of Biomedical Research Excellence in Kentucky22025

1 to 10 of 1,119Source NIH's project files

See all 1,119 nih grants

Papers1,924

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A case report of right ventricular cardiomyopathy with right ventricular diverticulum and atrial septal defect associated with biallelic PLD1 gene variants.Eur Heart J Case Rep202642799239PubTator, text miningPubMed
Novel compound heterozygous variants in the PLD1 gene causing cardiac valve dysplasia 1 complicated with dilated cardiomyopathy: a case report.Front Cardiovasc Med202642591229PubTator, text miningPubMed
Structural insights into the activation of phospholipase D1 by the small GTPase ARL11.J Biol Chem202642520942PubTator, text miningPubMed
PLD1 and PLD2 promote an immunosuppressive tumor microenvironment via CCL19-dependent macrophage polarization and PD-L1 induction.Exp Mol Med202642243532PubTator, text miningPubMed
Involvement of TRPA1 in Necrosis of Melanoma Cells via Phospholipase D1.Cells202642121861PubTator, text miningPubMed
Phospholipase D1 and phosphatidic acid are required for MVE fusion and exosome secretion.Biophys J202641947465PubTator, text miningPubMed
Quizartinib and omacetaxine mepesuccinate combination therapy in FLT3-ITD AML: a phase II trial.Nat Commun202641942459PubTator, text miningPubMed
Understanding the Molecular Basis of Pathological Retinal Angiogenesis: Roles of Lipids, Non-Coding RNAs, and Cellular Crosstalk.Invest Ophthalmol Vis Sci202641837574PubTator, text miningPubMed
Exploring the PLD1-tau interaction in Frontotemporal Dementia.bioRxiv202641726972PubTator, text miningPubMed
Shielding retinal pigment epithelium cells from high glucose-induced oxidative stress: the protective effect of phospholipase D (PLD) pathway inhibition.Biochim Biophys Acta Mol Cell Res202641617127PubTator, text miningPubMed

1 to 10 of 1,924

See all 1,924 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5337

GET https://conductscience.org/api/genes/v1/5337/patents?page=2