Gene · 5337
PLD1: phospholipase D1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PLD1: phospholipase D1. Genes, record 5337. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5337
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13393 | Phospholipase D1 | 1,074 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents34
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4803546 A1 | 2026-09-09 | 42 | Q13393 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6763 | Q13393 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6545 | Q13393 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6545 | Q13393 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6763 | Q13393 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 33604 | Q13393 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 33604 | Q13393 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7674 | Q13393 | Espacenet |
| JP 2023123507 A | 2023-09-05 | 286 | Q13393 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 33604 | Q13393 | Espacenet |
1 to 10 of 34
See all 34 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,119
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PLD1 papers | Newest fiscal year |
|---|---|---|---|
| T32CA009592 | Microenvironmental Influences in Cancer | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| R01GM089771 | Phosphoinositide signaling in autophagy | 5 | 2025 |
| P30CA043703 | Case Comprehensive Cancer Center Support Grant | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| T32CA059366 | Cancer Biology Training Grant | 4 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 3 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 3 | 2025 |
| R35GM128666 | Structure and regulation of lipid metabolism and transport | 3 | 2025 |
| P20GM103436 | IDeA Networks of Biomedical Research Excellence in Kentucky | 2 | 2025 |
1 to 10 of 1,119Source NIH's project files
See all 1,119 nih grantsPapers1,924
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A case report of right ventricular cardiomyopathy with right ventricular diverticulum and atrial septal defect associated with biallelic PLD1 gene variants. | Eur Heart J Case Rep | 2026 | 42799239 | PubTator, text mining | PubMed |
| Novel compound heterozygous variants in the PLD1 gene causing cardiac valve dysplasia 1 complicated with dilated cardiomyopathy: a case report. | Front Cardiovasc Med | 2026 | 42591229 | PubTator, text mining | PubMed |
| Structural insights into the activation of phospholipase D1 by the small GTPase ARL11. | J Biol Chem | 2026 | 42520942 | PubTator, text mining | PubMed |
| PLD1 and PLD2 promote an immunosuppressive tumor microenvironment via CCL19-dependent macrophage polarization and PD-L1 induction. | Exp Mol Med | 2026 | 42243532 | PubTator, text mining | PubMed |
| Involvement of TRPA1 in Necrosis of Melanoma Cells via Phospholipase D1. | Cells | 2026 | 42121861 | PubTator, text mining | PubMed |
| Phospholipase D1 and phosphatidic acid are required for MVE fusion and exosome secretion. | Biophys J | 2026 | 41947465 | PubTator, text mining | PubMed |
| Quizartinib and omacetaxine mepesuccinate combination therapy in FLT3-ITD AML: a phase II trial. | Nat Commun | 2026 | 41942459 | PubTator, text mining | PubMed |
| Understanding the Molecular Basis of Pathological Retinal Angiogenesis: Roles of Lipids, Non-Coding RNAs, and Cellular Crosstalk. | Invest Ophthalmol Vis Sci | 2026 | 41837574 | PubTator, text mining | PubMed |
| Exploring the PLD1-tau interaction in Frontotemporal Dementia. | bioRxiv | 2026 | 41726972 | PubTator, text mining | PubMed |
| Shielding retinal pigment epithelium cells from high glucose-induced oxidative stress: the protective effect of phospholipase D (PLD) pathway inhibition. | Biochim Biophys Acta Mol Cell Res | 2026 | 41617127 | PubTator, text mining | PubMed |
1 to 10 of 1,924
See all 1,924 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5337
GET https://conductscience.org/api/genes/v1/5337/patents?page=2