ConductScience.org, home

Gene · 5338

PLD2: phospholipase D2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. PLD2: phospholipase D2. Genes, record 5338. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5338

On this page

Gene

Symbol
PLD2
HGNC
Name
phospholipase D2
HGNC
NCBI Gene ID
5338
NCBI Gene
HGNC ID
HGNC:9068
HGNC
Ensembl
ENSG00000129219
NCBI Gene
Aliases
PLD1C
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14939Phospholipase D29336Ensembl, GeneID, HGNC

Source UniProt

Patents12

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457947O14939Espacenet
EP 4650780 A22025-11-192163O14939Espacenet
EP 4640849 A22025-10-29256O14939Espacenet
EP 4641201 A22025-10-291734O14939Espacenet
JP 2025519096 A2025-06-24256O14939Espacenet
JP 2025517969 A2025-06-121734O14939Espacenet
JP 2025517970 A2025-06-122163O14939Espacenet
US 11446398 B22022-09-2063422O14939Espacenet
JP 2022524081 A2022-04-27166393O14939Espacenet
JP 2019054813 A2019-04-11238382O14939Espacenet

1 to 10 of 12

See all 12 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants992

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePLD2 papersNewest fiscal year
T32CA009592Microenvironmental Influences in Cancer92025
R35GM118167Cellular Decision Making42025
P30CA043703Case Comprehensive Cancer Center Support Grant32025
R37GM058615Mechanisms and Physiology of COPI Transport32025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)32025
P30CA006973Regional Oncology Research Center22025
P30CA013330Cancer Center Support Grant22025
P30CA062203Cancer Center Support Grant22025
P30CA068485Cancer Center Support Grant22025
P30CA086862Cancer Center Support Grant22025

1 to 10 of 992Source NIH's project files

See all 992 nih grants

Papers1,399

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Phospholipase D2 acts upstream of PI4P 5-kinases in the response of neurons to extracellular viscosity.iScience202642699044PubTator, text miningPubMed
Metabolic Heterogeneity Across Heart Failure Subtypes Defined by Integrative Multi-Omics Analysis.J Cardiovasc Transl Res202642380371PubTator, text miningPubMed
PLD1 and PLD2 promote an immunosuppressive tumor microenvironment via CCL19-dependent macrophage polarization and PD-L1 induction.Exp Mol Med202642243532PubTator, text miningPubMed
The enigmatic role of tumor dormancy cells in gynecologic cancers.Front Immunol202642220495PubTator, text miningPubMed
Involvement of TRPA1 in Necrosis of Melanoma Cells via Phospholipase D1.Cells202642121861PubTator, text miningPubMed
Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation.Adv Sci (Weinh)202642011901PubTator, text miningPubMed
Global molecular landscape of early MASLD progression in human obesity.Elife202641870035PubTator, text miningPubMed
Corrigendum to 'Optimizing functional recovery after acute ischemic stroke through intensity and frequency of rehabilitation: The critical role of HIF-1α/PLD2/mTOR signaling mechanisms' [Experimental Neurology 397 (2026) 115568].
Exp Neurol202641794599PubTator, text miningPubMed
Exosomes: Roles and Therapeutic Potential in Pain.Biomedicines202641751313PubTator, text miningPubMed
Functionalized Biomaterials in the Investigation of the Effects of Fluid Shear Forces in the Immune Regulation of Cancer Progression and Metastasis.J Funct Biomater202641745543PubTator, text miningPubMed

1 to 10 of 1,399

See all 1,399 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5338

GET https://conductscience.org/api/genes/v1/5338/patents