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Gene · 5339

PLEC: plectin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PLEC: plectin. Genes, record 5339. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5339

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Gene

Symbol
PLEC
HGNC
Name
plectin
HGNC
NCBI Gene ID
5339
NCBI Gene
HGNC ID
HGNC:9069
HGNC
Ensembl
ENSG00000178209
NCBI Gene
Aliases
EBS1, EBS5A, EBS5B, EBS5C, EBS5D, EBSMD, EBSND, EBSO, EBSOG, EBSPA, HD1, LGMD2Q, LGMDR17, PCN, PLEC1, PLEC1b, PLTN
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15149Plectin4,68414Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458216Q15149Espacenet
EP 4650780 A22025-11-195521Q15149Espacenet
EP 4640849 A22025-10-29777Q15149Espacenet
EP 4641201 A22025-10-295134Q15149Espacenet
JP 2025519096 A2025-06-24777Q15149Espacenet
JP 2025517969 A2025-06-125134Q15149Espacenet
JP 2025517970 A2025-06-125521Q15149Espacenet
JP 2024009871 A2024-01-235Q15149Espacenet
JP 2023155262 A2023-10-201Q15149Espacenet
JP 2023036612 A2023-03-141Q15149Espacenet

1 to 10 of 57

See all 57 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,833

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePLEC papersNewest fiscal year
P30CA008748Cancer Center Support Grant102025
P30CA016672Cancer Center Support Grant92025
R01AR041836Function of Desmoglein 1/Pemphigus Foliaceus Antigen92025
R01AR043380Desmoplakin Assembly and Function in Epidermis82025
P30CA044579University of Virginia Cancer Center Support Grant62025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center62025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal42025
P30CA006973Regional Oncology Research Center32025
P30CA016042Cancer Center Support Grant32025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant32025

1 to 10 of 1,833Source NIH's project files

See all 1,833 nih grants

Papers2,747

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Graft Biology in the CRISPR Era: From Tissue Fusion to Genome Compatibility.Plant Environ Interact202642761838PubTator, text miningPubMed
Recurrent Severe Viral-Induced Rhabdomyolysis Associated With Underlying Genetic Variants in a Young Adult: A Case Report.Cureus202642755847PubTator, text miningPubMed
The role of plectin as a druggable target in papillary thyroid carcinoma: therapeutic potential of troglitazone.Front Immunol202642719128PubTator, text miningPubMed
Trio-Based Whole-Exome Sequencing Identifies Convergent Epithelial Junction-Related Pathways in Syndromic Hidradenitis Suppurativa.Dermatology202642709635PubTator, text miningPubMed
Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer.Front Immunol202642676425PubTator, text miningPubMed
AI-guided design of plectin-1-targeted 68Ga-radiotracers reveals EP300-mediated membrane relocalization of plectin-1 in pancreatic ductal adenocarcinoma.J Nanobiotechnology202642675478PubTator, text miningPubMed
Genetics-Informed Mapping Identifies a CRIM1-Associated Endocardial Inflammatory Remodeling State in Acute Myocardial Infarction.Med Sci Monit202642661361PubTator, text miningPubMed
Microtubule and cytoskeletal destabilization gene expression in the brain vasculature after experimental diffuse traumatic brain injury: Implications for neurodegenerative disease later in life.Neurosci Lett202642660275PubTator, text miningPubMed
Targeting the PLEC/TPM4 cytoskeletal axis: DT-13 inhibits colorectal cancer metastasis through direct binding to PLEC and inactivation of Akt/ERK signaling.Phytomedicine202642648206PubTator, text miningPubMed
FLNA promotes the progression of diabetic retinopathy by increasing M1 macrophages.Int J Ophthalmol202642639319PubTator, text miningPubMed

1 to 10 of 2,747

See all 2,747 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5339

GET https://conductscience.org/api/genes/v1/5339/patents?page=2