Gene · 5339
PLEC: plectin
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PLEC: plectin. Genes, record 5339. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5339
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q15149 | Plectin | 4,684 | 14 | Ensembl, GeneID, HGNC |
Source UniProt
Patents57
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58216 | Q15149 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5521 | Q15149 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 777 | Q15149 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5134 | Q15149 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 777 | Q15149 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5134 | Q15149 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5521 | Q15149 | Espacenet |
| JP 2024009871 A | 2024-01-23 | 5 | Q15149 | Espacenet |
| JP 2023155262 A | 2023-10-20 | 1 | Q15149 | Espacenet |
| JP 2023036612 A | 2023-03-14 | 1 | Q15149 | Espacenet |
1 to 10 of 57
See all 57 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,833
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PLEC papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| R01AR041836 | Function of Desmoglein 1/Pemphigus Foliaceus Antigen | 9 | 2025 |
| R01AR043380 | Desmoplakin Assembly and Function in Epidermis | 8 | 2025 |
| P30CA044579 | University of Virginia Cancer Center Support Grant | 6 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 6 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 4 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 3 | 2025 |
| P30CA016042 | Cancer Center Support Grant | 3 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,833Source NIH's project files
See all 1,833 nih grantsPapers2,747
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Graft Biology in the CRISPR Era: From Tissue Fusion to Genome Compatibility. | Plant Environ Interact | 2026 | 42761838 | PubTator, text mining | PubMed |
| Recurrent Severe Viral-Induced Rhabdomyolysis Associated With Underlying Genetic Variants in a Young Adult: A Case Report. | Cureus | 2026 | 42755847 | PubTator, text mining | PubMed |
| The role of plectin as a druggable target in papillary thyroid carcinoma: therapeutic potential of troglitazone. | Front Immunol | 2026 | 42719128 | PubTator, text mining | PubMed |
| Trio-Based Whole-Exome Sequencing Identifies Convergent Epithelial Junction-Related Pathways in Syndromic Hidradenitis Suppurativa. | Dermatology | 2026 | 42709635 | PubTator, text mining | PubMed |
| Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer. | Front Immunol | 2026 | 42676425 | PubTator, text mining | PubMed |
| AI-guided design of plectin-1-targeted 68Ga-radiotracers reveals EP300-mediated membrane relocalization of plectin-1 in pancreatic ductal adenocarcinoma. | J Nanobiotechnology | 2026 | 42675478 | PubTator, text mining | PubMed |
| Genetics-Informed Mapping Identifies a CRIM1-Associated Endocardial Inflammatory Remodeling State in Acute Myocardial Infarction. | Med Sci Monit | 2026 | 42661361 | PubTator, text mining | PubMed |
| Microtubule and cytoskeletal destabilization gene expression in the brain vasculature after experimental diffuse traumatic brain injury: Implications for neurodegenerative disease later in life. | Neurosci Lett | 2026 | 42660275 | PubTator, text mining | PubMed |
| Targeting the PLEC/TPM4 cytoskeletal axis: DT-13 inhibits colorectal cancer metastasis through direct binding to PLEC and inactivation of Akt/ERK signaling. | Phytomedicine | 2026 | 42648206 | PubTator, text mining | PubMed |
| FLNA promotes the progression of diabetic retinopathy by increasing M1 macrophages. | Int J Ophthalmol | 2026 | 42639319 | PubTator, text mining | PubMed |
1 to 10 of 2,747
See all 2,747 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5339
GET https://conductscience.org/api/genes/v1/5339/patents?page=2