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PLG: plasminogen

1 protein, 284 patents, 9 drugs, 288 trials, 8,161 NIH grants and 29,616 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPLGHGNC
NameplasminogenHGNC
NCBI Gene ID5340NCBI Gene
HGNC IDHGNC:9071HGNC
EnsemblENSG00000122194NCBI Gene
AliasesHAE4NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00747Plasminogen81049Ensembl, GeneID, HGNCUniProt

Patents 284

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4770664 A12026-07-082P00747Espacenet
JP 2026009990 A2026-01-214P00747Espacenet
JP 2025539229 A2025-12-044P00747Espacenet
EP 4650780 A22025-11-194588P00747Espacenet
JP 2025169942 A2025-11-141208P00747Espacenet
JP 2025537179 A2025-11-144P00747Espacenet
EP 4641201 A22025-10-294144P00747Espacenet
JP 2025147176 A2025-10-0610513P00747Espacenet
JP 2025532862 A2025-10-0349P00747Espacenet
EP 4613285 A12025-09-104P00747Espacenet

Drugs 9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMEDIPLASECHEMBL2108361Plasminogen activatorACTIVATORChEMBL
AMINOCAPROIC ACIDCHEMBL1046Plasminogen inhibitorINHIBITORChEMBL
ANISTREPLASECHEMBL2108250Plasminogen activatorACTIVATORChEMBL
APROTININCHEMBL1201619Plasminogen inhibitorINHIBITORChEMBL
DEFIBROTIDECHEMBL2108396Plasminogen activatorACTIVATORChEMBL
DEFIBROTIDE SODIUMCHEMBL3707226Plasminogen activatorACTIVATORChEMBL
DESMOTEPLASECHEMBL2109084Plasminogen activatorACTIVATORChEMBL
STREPTOKINASECHEMBL2108147Plasminogen activatorACTIVATORChEMBL
TRANEXAMIC ACIDCHEMBL877Plasminogen inhibitorINHIBITORChEMBL

Trials 288

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07581457TRANEXAMIC ACIDClinicalTrials.gov
NCT07540702TRANEXAMIC ACIDClinicalTrials.gov
NCT07540026TRANEXAMIC ACIDClinicalTrials.gov
NCT07530016TRANEXAMIC ACIDClinicalTrials.gov
NCT07495748TRANEXAMIC ACIDClinicalTrials.gov
NCT07494032TRANEXAMIC ACIDClinicalTrials.gov
NCT07481682TRANEXAMIC ACIDClinicalTrials.gov
NCT07448415TRANEXAMIC ACIDPHASE2/PHASE3ClinicalTrials.gov
NCT07442643TRANEXAMIC ACIDClinicalTrials.gov
NCT07434453TRANEXAMIC ACIDClinicalTrials.gov

NIH grants 8161

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
T32GM008315Mechanisms of Trauma-Induced Coagulopathy462,025NIH's project files
R01HL055374Unraveling the role of tPA in the neurovascular unit272,025NIH's project files
P30CA008748Cancer Center Support Grant202,025NIH's project files
P30CA016672Cancer Center Support Grant152,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT152,025NIH's project files
P51OD011132Emory National Primate Research Center142,025NIH's project files
R01HL056051Fibrin(ogen) Structure and Interactions142,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award142,025NIH's project files
I01BX003441TPA Protects the Synapse in the Iscemic Brain132,025NIH's project files
R35GM119526Mechanistic Elucidation and Targeted Therapy of Organ Injury and Inflammation following Trauma112,025NIH's project files

Papers 29616

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819376PubTator, text miningPubMed
42813761PubTator, text miningPubMed
42803058PubTator, text miningPubMed
42802271PubTator, text miningPubMed
42793067PubTator, text miningPubMed
42790202PubTator, text miningPubMed
42785651PubTator, text miningPubMed
42780071PubTator, text miningPubMed
42779360PubTator, text miningPubMed
42768826PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license