Gene · 5341
PLEK: pleckstrin
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PLEK: pleckstrin. Genes, record 5341. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5341
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P08567 | Pleckstrin | 350 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents41
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 623 | P08567 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4388 | P08567 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15498 | P08567 | Espacenet |
| JP 2025138725 A | 2025-09-25 | 1865 | P08567 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 623 | P08567 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15498 | P08567 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4388 | P08567 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15498 | P08567 | Espacenet |
| WO 2024252368 A2 | 2024-12-12 | 29 | P08567 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15337 | P08567 | Espacenet |
1 to 10 of 41
See all 41 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,250
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PLEK papers | Newest fiscal year |
|---|---|---|---|
| ZIAAI000645 | Development and Clinical Application of Gene and Cell therapies for Patients with Immune Deficiencies | 12 | 2025 |
| ZIAAI000644 | Gene Therapy and Hematopoietic Stem Cell Research to Treat Inherited Primary Immune Deficiencies | 9 | 2025 |
| R01AI043957 | Structural Studies of a T cell Specific Tyrosine Kinase | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
| P30CA082709 | Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant | 5 | 2025 |
| R01AG031867 | Protein aggregation in inclusion body and myofibrillar myopathies | 5 | 2025 |
| ZIAAI000646 | Transgenic Animal Models Of Human Immune Defects | 5 | 2025 |
| P30DK017047 | Diabetes Research Center | 4 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 4 | 2025 |
1 to 10 of 2,250Source NIH's project files
See all 2,250 nih grantsPapers3,086
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Correction to: "Delivery of Pleckstrin-Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis". | Adv Sci (Weinh) | 2026 | 42809032 | PubTator, text mining | PubMed |
| Cancer-associated synonymous mutations target mRNA structures and protein activity. | Trends Cancer | 2026 | 42706007 | PubTator, text mining | PubMed |
| Pathogenic KIF1A variants differentially disrupt axonal trafficking and impede synaptic development. | J Cell Biol | 2026 | 42704317 | PubTator, text mining | PubMed |
| Single-cell transcriptomic analysis reveals systemic immune dysregulation and identifies PLEK as a candidate hub gene associated with CD8+ T-cell activation in myasthenia gravis. | J Neuroimmunol | 2026 | 42667813 | PubTator, text mining | PubMed |
| Genome-wide Analysis Highlights rs4671908 and rs2238431 as Predictors of Survival in Nasopharyngeal Carcinoma. | Anticancer Res | 2026 | 42203326 | PubTator, text mining | PubMed |
| Costunolide, a Sesquiterpene Lactone, Protects Against Platelet Activation and Thrombus Formation. | Cells | 2026 | 42193947 | PubTator, text mining | PubMed |
| Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Covalent Binder. | J Med Chem | 2026 | 42130460 | PubTator, text mining | PubMed |
| Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis. | Nature | 2026 | 42020739 | PubTator, text mining | PubMed |
| "EPAC1: Molecular architecture, physiological regulation, and therapeutic implications in diseases". | Int J Biochem Cell Biol | 2026 | 41966519 | PubTator, text mining | PubMed |
| Inflammatory arthritis irAE may represent a unique autoimmune disease primarily driven by T cells but likely not autoantibodies. | Sci Adv | 2026 | 41920990 | PubTator, text mining | PubMed |
1 to 10 of 3,086
See all 3,086 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5341
GET https://conductscience.org/api/genes/v1/5341/patents?page=2