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Gene · 5341

PLEK: pleckstrin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PLEK: pleckstrin. Genes, record 5341. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5341

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Gene

Symbol
PLEK
HGNC
Name
pleckstrin
HGNC
NCBI Gene ID
5341
NCBI Gene
HGNC ID
HGNC:9070
HGNC
Ensembl
ENSG00000115956
NCBI Gene
Aliases
P47, PLEK1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P08567Pleckstrin3508Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-29623P08567Espacenet
EP 4641202 A22025-10-294388P08567Espacenet
JP 2025147176 A2025-10-0615498P08567Espacenet
JP 2025138725 A2025-09-251865P08567Espacenet
JP 2025517969 A2025-06-12623P08567Espacenet
JP 2025028160 A2025-02-2815498P08567Espacenet
KR 1020250017231 A2025-02-044388P08567Espacenet
KR 1020250010750 A2025-01-2115498P08567Espacenet
WO 2024252368 A22024-12-1229P08567Espacenet
JP 2024109657 A2024-08-1415337P08567Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,250

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePLEK papersNewest fiscal year
ZIAAI000645Development and Clinical Application of Gene and Cell therapies for Patients with Immune Deficiencies122025
ZIAAI000644Gene Therapy and Hematopoietic Stem Cell Research to Treat Inherited Primary Immune Deficiencies92025
R01AI043957Structural Studies of a T cell Specific Tyrosine Kinase62025
P30CA016672Cancer Center Support Grant52025
P30CA068485Cancer Center Support Grant52025
P30CA082709Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant52025
R01AG031867Protein aggregation in inclusion body and myofibrillar myopathies52025
ZIAAI000646Transgenic Animal Models Of Human Immune Defects52025
P30DK017047Diabetes Research Center42025
P30ES006694Southwest Environmental Health Sciences Center42025

1 to 10 of 2,250Source NIH's project files

See all 2,250 nih grants

Papers3,086

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Correction to: "Delivery of Pleckstrin-Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis".Adv Sci (Weinh)202642809032PubTator, text miningPubMed
Cancer-associated synonymous mutations target mRNA structures and protein activity.Trends Cancer202642706007PubTator, text miningPubMed
Pathogenic KIF1A variants differentially disrupt axonal trafficking and impede synaptic development.J Cell Biol202642704317PubTator, text miningPubMed
Single-cell transcriptomic analysis reveals systemic immune dysregulation and identifies PLEK as a candidate hub gene associated with CD8+ T-cell activation in myasthenia gravis.J Neuroimmunol202642667813PubTator, text miningPubMed
Genome-wide Analysis Highlights rs4671908 and rs2238431 as Predictors of Survival in Nasopharyngeal Carcinoma.Anticancer Res202642203326PubTator, text miningPubMed
Costunolide, a Sesquiterpene Lactone, Protects Against Platelet Activation and Thrombus Formation.Cells202642193947PubTator, text miningPubMed
Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Covalent Binder.J Med Chem202642130460PubTator, text miningPubMed
Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis.Nature202642020739PubTator, text miningPubMed
"EPAC1: Molecular architecture, physiological regulation, and therapeutic implications in diseases".Int J Biochem Cell Biol202641966519PubTator, text miningPubMed
Inflammatory arthritis irAE may represent a unique autoimmune disease primarily driven by T cells but likely not autoantibodies.Sci Adv202641920990PubTator, text miningPubMed

1 to 10 of 3,086

See all 3,086 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5341

GET https://conductscience.org/api/genes/v1/5341/patents?page=2