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PLK1: polo like kinase 1

1 protein, 80 patents, 8 drugs, 40 trials, 5,572 NIH grants and 12,637 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPLK1HGNC
Namepolo like kinase 1HGNC
NCBI Gene ID5347NCBI Gene
HGNC IDHGNC:9077HGNC
EnsemblENSG00000166851NCBI Gene
AliasesPLK, STPK13NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P53350Serine/threonine-protein kinase PLK160385Ensembl, GeneID, HGNCUniProt

Patents 80

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4825362 A12026-10-2149P53350Espacenet
EP 4803075 A12026-09-0949P53350Espacenet
WO 2026013165 A12026-01-152P53350Espacenet
EP 4650780 A22025-11-193982P53350Espacenet
EP 4641201 A22025-10-293562P53350Espacenet
EP 4641202 A22025-10-294761P53350Espacenet
JP 2025517969 A2025-06-123562P53350Espacenet
JP 2025517970 A2025-06-123982P53350Espacenet
JP 2025512950 A2025-04-2210P53350Espacenet
JP 2025505440 A2025-02-2649P53350Espacenet

Drugs 8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BI-2536CHEMBL513909Serine/threonine-protein kinase PLK1 inhibitorINHIBITORChEMBL
CAFUSERTIBCHEMBL3545354Serine/threonine-protein kinase PLK1 inhibitorINHIBITORChEMBL
GSK-461364CHEMBL1908394Serine/threonine-protein kinase PLK1 inhibitorINHIBITORChEMBL
HMN-214CHEMBL3991927Serine/threonine-protein kinase PLK1 inhibitorINHIBITORChEMBL
MK-1496CHEMBL5314387Serine/threonine-protein kinase PLK1 inhibitorINHIBITORChEMBL
ONVANSERTIBCHEMBL1738758Serine/threonine-protein kinase PLK1 inhibitorINHIBITORChEMBL
TAK-960CHEMBL2392545Serine/threonine-protein kinase PLK1 inhibitorINHIBITORChEMBL
VOLASERTIBCHEMBL1233528Serine/threonine-protein kinase PLK1 inhibitorINHIBITORChEMBL

Trials 40

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06736717ONVANSERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT06398587ONVANSERTIBPHASE2ClinicalTrials.gov
NCT06106308ONVANSERTIBPHASE2ClinicalTrials.gov
NCT05593328ONVANSERTIBPHASE2ClinicalTrials.gov
NCT05549661ONVANSERTIBPHASE1ClinicalTrials.gov
NCT05450965ONVANSERTIBPHASE2ClinicalTrials.gov
NCT05383196ONVANSERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT04752696ONVANSERTIBPHASE2ClinicalTrials.gov
NCT04446793ONVANSERTIBClinicalTrials.gov
NCT04005690ONVANSERTIBEARLY_PHASE1ClinicalTrials.gov

NIH grants 5572

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1172,025NIH's project files
P30CA008748Cancer Center Support Grant652,025NIH's project files
R01CA157429Overcoming Drug Resistance of Castration-Resistant Prostate Cancer352,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase282,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant252,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant242,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support232,025NIH's project files
P30CA023168Cancer Center Support Grant222,025NIH's project files
P30CA006973Regional Oncology Research Center212,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant202,025NIH's project files

Papers 12637

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42787848PubTator, text miningPubMed
42786371PubTator, text miningPubMed
42779575PubTator, text miningPubMed
42778195PubTator, text miningPubMed
42761981PubTator, text miningPubMed
42759549PubTator, text miningPubMed
42749405PubTator, text miningPubMed
42724831PubTator, text miningPubMed
42719140PubTator, text miningPubMed
42715328PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license