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Gene · 5351

PLOD1: procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PLOD1: procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. Genes, record 5351. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5351

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Gene

Symbol
PLOD1
HGNC
Name
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
HGNC
NCBI Gene ID
5351
NCBI Gene
HGNC ID
HGNC:9081
HGNC
Ensembl
ENSG00000083444
NCBI Gene
Aliases
EDS6, EDSKCL1, LH, LH1, LLH, PLOD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q02809Procollagen-lysine,2-oxoglutarate 5-dioxygenase 17270Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459072Q02809Espacenet
EP 4650780 A22025-11-19188Q02809Espacenet
JP 2025147176 A2025-10-0610522Q02809Espacenet
JP 2025529142 A2025-09-047381Q02809Espacenet
US 12371689 B22025-07-297381Q02809Espacenet
JP 2025517970 A2025-06-12188Q02809Espacenet
JP 2025028160 A2025-02-2810522Q02809Espacenet
KR 1020250010750 A2025-01-2110522Q02809Espacenet
JP 2024109657 A2024-08-1410529Q02809Espacenet
US 11446398 B22022-09-2066648Q02809Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants884

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePLOD1 papersNewest fiscal year
ZIAHD000256Collagen-related diseases42025
P30AI027763UCSF-Bay Area Center for AIDS Research32025
P30CA008748Cancer Center Support Grant32025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens22025
P01CA092584Structural Cell Biology of DNA Repair Machines22025
P20GM103436IDeA Networks of Biomedical Research Excellence in Kentucky22025
P20GM121327University of Kentucky Center for Cancer Metabolism22025
P30CA006973Regional Oncology Research Center22025
P30CA016086Cancer Center Support Grant22025
P30CA016520Abramson Cancer Center Support Grant22025

1 to 10 of 884Source NIH's project files

See all 884 nih grants

Papers1,607

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7-dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma.Adv Sci (Weinh)202642801660PubTator, text miningPubMed
Recombinant Production and Characterization of Human Enzymes Responsible for Collagen Lysine Post-translational Modifications.Methods Mol Biol202642681151PubTator, text miningPubMed
Between myopathy and mortality: Challenges in the diagnosis of PLOD1-related kyphoscoliotic Ehlers-Danlos syndrome.J Neuromuscul Dis202642667135PubTator, text miningPubMed
Metabolic-epigenetic reprogramming via the PLOD1-PFKP axis drives cisplatin resistance in HNSCC.Acta Pharm Sin B202642592154PubTator, text miningPubMed
Lactate-induced H3K4me3 histone mark promotes PLOD1-driven prostate cancer invasion.Cell Death Dis202642414254PubTator, text miningPubMed
PLOD1 Drives Head and Neck Squamous Cell Carcinoma Progression Through P4HA2-Mediated Activation of the FAK/PI3K/AKT/mTOR Axis.J Cell Mol Med202642400233PubTator, text miningPubMed
From Stress to Survival: Trophoblast-Derived Extracellular Vesicle Proteome Captures Aspirin-Driven Cellular Reprogramming in a Preeclampsia Model.Pharmaceutics202642357292PubTator, text miningPubMed
Structural and mechanistic insights into the catalytic versatility of lysyl hydroxylases in collagen post-translational modifications.J Biol Chem202642314906PubTator, text miningPubMed
Kyphoscoliotic Ehlers-Danlos syndrome due to a novel homozygous PLOD1 variant: severe vascular involvement and molecular diagnosis.BMC Med Genomics202642277864PubTator, text miningPubMed
Proteomic profiling of olfactory exfoliates from people with subjective cognitive complaints reveal networks of olfactory biomarkers of cognitive performance.Front Aging Neurosci202642253369PubTator, text miningPubMed

1 to 10 of 1,607

See all 1,607 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5351

GET https://conductscience.org/api/genes/v1/5351/patents?page=2