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Gene · 5352

PLOD2: procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PLOD2: procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. Genes, record 5352. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5352

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Gene

Symbol
PLOD2
HGNC
Name
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
HGNC
NCBI Gene ID
5352
NCBI Gene
HGNC ID
HGNC:9082
HGNC
Ensembl
ENSG00000152952
NCBI Gene
Aliases
BRKS2, LH2, TLH
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00469Procollagen-lysine,2-oxoglutarate 5-dioxygenase 27370Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459079O00469Espacenet
EP 4650780 A22025-11-197741O00469Espacenet
EP 4641201 A22025-10-297799O00469Espacenet
JP 2025147176 A2025-10-0610526O00469Espacenet
JP 2025529142 A2025-09-043521O00469Espacenet
JP 2025529142 A2025-09-047382O00469Espacenet
US 12371689 B22025-07-293521O00469Espacenet
US 12371689 B22025-07-297382O00469Espacenet
JP 2025517969 A2025-06-127799O00469Espacenet
JP 2025517970 A2025-06-127741O00469Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants805

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePLOD2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant82025
P30CA016672Cancer Center Support Grant72025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
ZIAHD000256Collagen-related diseases42025
P30CA046934University of Colorado Cancer Center Support Grant32025
P30CA091842Cancer Center Support Grant32025
R01CA251067Elucidating pro-metastatic collagen modifying activities of lysyl hydroxylase 232025
T32CA153952T32: Predoctoral and Postdoctoral Training Program in Nanotechnology for Cancer Research32025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens22025
P20GM121327University of Kentucky Center for Cancer Metabolism22025

1 to 10 of 805Source NIH's project files

See all 805 nih grants

Papers1,610

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Phenotypic spectrum and quality of life in pediatric Bruck syndrome due to FKBP10 and PLOD2 variants: a 2-center United Arab Emirates experience.JBMR Plus202642741659PubTator, text miningPubMed
CCL5 and GLUT1 define leader cells in collective invasion of colorectal cancer.J Pathol202642583704PubTator, text miningPubMed
L-leucine-incorporated 3D-printed SilMA hydrogel scaffolds promote calvarial defect repair with PLOD2-associated collagen remodeling.Mater Today Bio202642576944PubTator, text miningPubMed
PLOD2 promotes colorectal cancer progression and immune escape via attenuating CD8+ T cells function.Int Immunopharmacol202642503264PubTator, text miningPubMed
Extending the global landscape of Bruck syndrome: Case series of Indonesian and Ukrainian patients with PLOD2 pathogenic variants and literature review.Bone Rep202642471862PubTator, text miningPubMed
Prospective exploratory pilot study of 18 F-FMISO PET/CT for assessing tumor hypoxia in soft tissue sarcomas.Cancer Imaging202642321847PubTator, text miningPubMed
Structural and mechanistic insights into the catalytic versatility of lysyl hydroxylases in collagen post-translational modifications.J Biol Chem202642314906PubTator, text miningPubMed
Mapping cell type-resolved transcriptomic profiles to patient survival in pancreatic cancer.Cancer Cell202642276047PubTator, text miningPubMed
Clinical Variability Within the PLOD2-Associated Phenotypic Continuum: Three Novel Variants in Four Patients from a Descriptive Case Series.Genes (Basel)202642195013PubTator, text miningPubMed
Salvianolic Acid B Inhibited LH2 Expression to Reduce Collagen Synthesis in Pulmonary Fibrosis.J Cell Mol Med202642179136PubTator, text miningPubMed

1 to 10 of 1,610

See all 1,610 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5352

GET https://conductscience.org/api/genes/v1/5352/patents?page=2