Gene · 53637
S1PR5: sphingosine-1-phosphate receptor 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. S1PR5: sphingosine-1-phosphate receptor 5. Genes, record 53637. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/53637
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9H228 | Sphingosine 1-phosphate receptor 5 | 398 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents98
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 65289 | Q9H228 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 65291 | Q9H228 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5774 | Q9H228 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 310 | Q9H228 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3814 | Q9H228 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3814 | Q9H228 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5774 | Q9H228 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 35204 | Q9H228 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 35205 | Q9H228 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 310 | Q9H228 | Espacenet |
1 to 10 of 98
See all 98 patentsDrugs9
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMISELIMOD | CHEMBL3707375 | Sphingosine 1-phosphate receptor modulator | MODULATOR | ChEMBL |
| AMISELIMOD HYDROCHLORIDE | CHEMBL3707374 | Sphingosine 1-phosphate receptor modulator | MODULATOR | ChEMBL |
| ETRASIMOD | CHEMBL3358920 | Sphingosine 1-phosphate receptor Edg-8 modulator | MODULATOR | ChEMBL |
| ETRASIMOD ARGININE | CHEMBL3989933 | Sphingosine 1-phosphate receptor Edg-8 modulator | MODULATOR | ChEMBL |
| FINGOLIMOD | CHEMBL314854 | Sphingosine 1-phosphate receptor agonist | AGONIST | ChEMBL |
| FINGOLIMOD | CHEMBL314854 | Sphingosine 1-phosphate receptor binding agent | BINDING AGENT | ChEMBL |
| FINGOLIMOD HYDROCHLORIDE | CHEMBL544665 | Sphingosine 1-phosphate receptor agonist | AGONIST | ChEMBL |
| FINGOLIMOD LAURYL SULFATE | CHEMBL5095050 | Sphingosine 1-phosphate receptor binding agent | BINDING AGENT | ChEMBL |
| OZANIMOD | CHEMBL3707247 | Sphingosine 1-phosphate receptor 5 modulator | MODULATOR | ChEMBL |
Trials141
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07483632 | FINGOLIMOD | PHASE3 | ClinicalTrials.gov | |
| NCT07470879 | ETRASIMOD | PHASE2 | ClinicalTrials.gov | |
| NCT07459686 | ETRASIMOD ARGININE | ClinicalTrials.gov | ||
| NCT07271069 | OZANIMOD | ClinicalTrials.gov | ||
| NCT07243639 | ETRASIMOD | ClinicalTrials.gov | ||
| NCT07220252 | FINGOLIMOD | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT06862960 | OZANIMOD | PHASE2 | ClinicalTrials.gov | |
| NCT06529406 | OZANIMOD | PHASE4 | ClinicalTrials.gov | |
| NCT06424067 | FINGOLIMOD | PHASE2 | ClinicalTrials.gov | |
| NCT06408259 | FINGOLIMOD | PHASE3 | ClinicalTrials.gov |
1 to 10 of 141
See all 141 trialsNIH grants806
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | S1PR5 papers | Newest fiscal year |
|---|---|---|---|
| P01CA097132 | Sphingolipids in Cancer Biology and Therapy | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA016059 | Massey Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| IK6BX004477 | BLR&D Research Career Scientist Award Application | 3 | 2025 |
| ZICES102445 | Gene Expression and Microarrays | 3 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 2 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 2 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 2 | 2025 |
| P30DK120515 | San Diego Digestive Diseases Research Center | 2 | 2025 |
| R01AI066232 | Regulation of memory CD8 T cell development | 2 | 2025 |
1 to 10 of 806Source NIH's project files
See all 806 nih grantsPapers1,387
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Effects of sphingosine-1-phosphate receptor modulators on remyelination in multiple sclerosis: evidence from in vitro experiments, animal models and human studies. | Front Immunol | 2026 | 42780639 | PubTator, text mining | PubMed |
| Identification and functional experimental verification of efferocytosis-related diagnostic biomarkers for sepsis. | Int J Biochem Cell Biol | 2026 | 42777907 | PubTator, text mining | PubMed |
| [Pharmacological properties and clinical efficacy of sphingosine 1-phosphate (S1P) receptor modulator, Etrasimod (Velsipity® 2 mg tablets)]. | Nihon Yakurigaku Zasshi | 2026 | 42686559 | PubTator, text mining | PubMed |
| Rbp-Jκ controls NK cell late maturation and migration via chromatin landscape remodeling. | Proc Natl Acad Sci U S A | 2026 | 42679032 | PubTator, text mining | PubMed |
| Fungal Infections Associated with Sphingosine 1-Phosphate Receptor Modulators: Immunological Mechanisms, Clinical Patterns, and Management Considerations. | Microorganisms | 2026 | 42655205 | PubTator, text mining | PubMed |
| Granzyme K CD8⁺ T cells with tissue-resident features promote intestinal inflammation in patients with Crohn's disease. | Exp Mol Med | 2026 | 42409960 | PubTator, text mining | PubMed |
| The Role of Sphingosine-1-Phosphate Signaling in Cerebral Ischemia/Reperfusion Injury and Alzheimer's Disease Pathology. | Int J Mol Sci | 2026 | 42352925 | PubTator, text mining | PubMed |
| Sphingosine-1-phosphate: Mechanisms and therapeutic potential in wound repair. | Biomed Pharmacother | 2026 | 42308917 | PubTator, text mining | PubMed |
| Effects of Sphingosine 1-phosphate Modulators on Central Remyelination: A Systematic Review of Animal Models. | Cell Mol Neurobiol | 2026 | 42268470 | PubTator, text mining | PubMed |
| Sphingosine-1-Phosphate Is a Key Signaling Molecule in Normal Conditions and in Multiple Sclerosis. | Biochemistry (Mosc) | 2026 | 42219383 | PubTator, text mining | PubMed |
1 to 10 of 1,387
See all 1,387 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/53637
GET https://conductscience.org/api/genes/v1/53637/patents?page=2