ConductScience.org, home

Gene · 53637

S1PR5: sphingosine-1-phosphate receptor 5

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. S1PR5: sphingosine-1-phosphate receptor 5. Genes, record 53637. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/53637

On this page

Gene

Symbol
S1PR5
HGNC
Name
sphingosine-1-phosphate receptor 5
HGNC
NCBI Gene ID
53637
NCBI Gene
HGNC ID
HGNC:14299
HGNC
Ensembl
ENSG00000180739
NCBI Gene
Aliases
EDG8, Edg-8, S1P5, SPPR-1, SPPR-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H228Sphingosine 1-phosphate receptor 53982Ensembl, GeneID, HGNC

Source UniProt

Patents98

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465289Q9H228Espacenet
JP 2026004568 A2026-01-1465291Q9H228Espacenet
EP 4650780 A22025-11-195774Q9H228Espacenet
EP 4641202 A22025-10-29310Q9H228Espacenet
JP 2025529142 A2025-09-043814Q9H228Espacenet
US 12371689 B22025-07-293814Q9H228Espacenet
JP 2025517970 A2025-06-125774Q9H228Espacenet
JP 2025032204 A2025-03-1135204Q9H228Espacenet
JP 2025032204 A2025-03-1135205Q9H228Espacenet
KR 1020250017231 A2025-02-04310Q9H228Espacenet

1 to 10 of 98

See all 98 patents

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMISELIMODCHEMBL3707375Sphingosine 1-phosphate receptor modulatorMODULATORChEMBL
AMISELIMOD HYDROCHLORIDECHEMBL3707374Sphingosine 1-phosphate receptor modulatorMODULATORChEMBL
ETRASIMODCHEMBL3358920Sphingosine 1-phosphate receptor Edg-8 modulatorMODULATORChEMBL
ETRASIMOD ARGININECHEMBL3989933Sphingosine 1-phosphate receptor Edg-8 modulatorMODULATORChEMBL
FINGOLIMODCHEMBL314854Sphingosine 1-phosphate receptor agonistAGONISTChEMBL
FINGOLIMODCHEMBL314854Sphingosine 1-phosphate receptor binding agentBINDING AGENTChEMBL
FINGOLIMOD HYDROCHLORIDECHEMBL544665Sphingosine 1-phosphate receptor agonistAGONISTChEMBL
FINGOLIMOD LAURYL SULFATECHEMBL5095050Sphingosine 1-phosphate receptor binding agentBINDING AGENTChEMBL
OZANIMODCHEMBL3707247Sphingosine 1-phosphate receptor 5 modulatorMODULATORChEMBL

Trials141

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants806

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleS1PR5 papersNewest fiscal year
P01CA097132Sphingolipids in Cancer Biology and Therapy82025
P30CA008748Cancer Center Support Grant62025
P30CA016059Massey Cancer Center - Cancer Center Support Grant52025
IK6BX004477BLR&D Research Career Scientist Award Application32025
ZICES102445Gene Expression and Microarrays32025
P30CA016056Roswell Park Cancer Center Support Grant22025
P30CA016087Cancer Center Support Grant22025
P30DK020572Michigan Diabetes Research Center (MDRC)22025
P30DK120515San Diego Digestive Diseases Research Center22025
R01AI066232Regulation of memory CD8 T cell development22025

1 to 10 of 806Source NIH's project files

See all 806 nih grants

Papers1,387

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Effects of sphingosine-1-phosphate receptor modulators on remyelination in multiple sclerosis: evidence from in vitro experiments, animal models and human studies.Front Immunol202642780639PubTator, text miningPubMed
Identification and functional experimental verification of efferocytosis-related diagnostic biomarkers for sepsis.Int J Biochem Cell Biol202642777907PubTator, text miningPubMed
[Pharmacological properties and clinical efficacy of sphingosine 1-phosphate (S1P) receptor modulator, Etrasimod (Velsipity® 2 mg tablets)].Nihon Yakurigaku Zasshi202642686559PubTator, text miningPubMed
Rbp-Jκ controls NK cell late maturation and migration via chromatin landscape remodeling.Proc Natl Acad Sci U S A202642679032PubTator, text miningPubMed
Fungal Infections Associated with Sphingosine 1-Phosphate Receptor Modulators: Immunological Mechanisms, Clinical Patterns, and Management Considerations.Microorganisms202642655205PubTator, text miningPubMed
Granzyme K CD8⁺ T cells with tissue-resident features promote intestinal inflammation in patients with Crohn's disease.Exp Mol Med202642409960PubTator, text miningPubMed
The Role of Sphingosine-1-Phosphate Signaling in Cerebral Ischemia/Reperfusion Injury and Alzheimer's Disease Pathology.Int J Mol Sci202642352925PubTator, text miningPubMed
Sphingosine-1-phosphate: Mechanisms and therapeutic potential in wound repair.Biomed Pharmacother202642308917PubTator, text miningPubMed
Effects of Sphingosine 1-phosphate Modulators on Central Remyelination: A Systematic Review of Animal Models.Cell Mol Neurobiol202642268470PubTator, text miningPubMed
Sphingosine-1-Phosphate Is a Key Signaling Molecule in Normal Conditions and in Multiple Sclerosis.Biochemistry (Mosc)202642219383PubTator, text miningPubMed

1 to 10 of 1,387

See all 1,387 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/53637

GET https://conductscience.org/api/genes/v1/53637/patents?page=2