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Gene · 5378

PMS1: PMS1 homolog 1, mismatch repair system component

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PMS1: PMS1 homolog 1, mismatch repair system component. Genes, record 5378. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5378

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Gene

Symbol
PMS1
HGNC
Name
PMS1 homolog 1, mismatch repair system component
HGNC
NCBI Gene ID
5378
NCBI Gene
HGNC ID
HGNC:9121
HGNC
Ensembl
ENSG00000064933
NCBI Gene
Aliases
HNPCC3, MLH2, PMSL1, hPMS1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P54277PMS1 protein homolog 19321Ensembl, GeneID, HGNC

Source UniProt

Patents90

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1913408P54277Espacenet
EP 4641201 A22025-10-2915302P54277Espacenet
JP 2025517969 A2025-06-1215302P54277Espacenet
JP 2025517970 A2025-06-1213408P54277Espacenet
JP 2024123008 A2024-09-107734P54277Espacenet
US 11504404 B22022-11-22167P54277Espacenet
US 11446398 B22022-09-2064367P54277Espacenet
JP 2022524081 A2022-04-27167338P54277Espacenet
JP 2021169490 A2021-10-28253P54277Espacenet
KR 1020210129616 A2021-10-2839P54277Espacenet

1 to 10 of 90

See all 90 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,260

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePMS1 papersNewest fiscal year
R01GM050006Enzymology of Mismatch Repair in Yeast202025
P30CA016672Cancer Center Support Grant162025
P30CA008748Cancer Center Support Grant152025
R01NS049206Huntington's Disease Repeat Instability and Pathogenesis82025
P01CA092584Structural Cell Biology of DNA Repair Machines62025
P30CA016056Roswell Park Cancer Center Support Grant62025
P30CA016058Cancer Center Support Grant62025
R35GM134872Roles for Mismatch Repair Proteins in Maintaining Genome Stability52025
ZIADK057808Understanding the mutational mechanism responsible for the Repeat Expansion Diseases52025
ZIAES065089Studies Of DNA Mismatch Repair52025

1 to 10 of 1,260Source NIH's project files

See all 1,260 nih grants

Papers1,886

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Prevalence of pathogenic germline variants and indications for testing in a diverse community-based endometrial cancer cohort.Gynecol Oncol202642822083PubTator, text miningPubMed
Targeted quantification assays for DNA repair and handling proteins and interactions in Huntington's disease models.bioRxiv202642619717PubTator, text miningPubMed
Human PMS1-dependent non-canonical mismatch repair engages with MBD4 to repair methylated CpG deamination.Nucleic Acids Res202642578366PubTator, text miningPubMed
Potential advantage of clinical exome sequencing in BRCA1/2-negative families: a retrospective study of a cohort of 500 patients at a high-risk for hereditary cancers.J Med Genet202642498519PubTator, text miningPubMed
Transcriptomics Reveals L-Carnitine to Enhance Semen Quality in Malabari Bucks via Nutrigenomic Regulation of Key Biological Processes Associated With Male Fertility.Reprod Domest Anim202642429318PubTator, text miningPubMed
Identification and validation of biomarkers related to mismatch repair for prognosis prediction in glioma.Front Immunol202642416056PubTator, text miningPubMed
A retrospective study of differential prognostic factors in early-onset versus late-onset colorectal cancer: a comprehensive clinical and machine learning analysis.PeerJ202642405254PubTator, text miningPubMed
Mismatch repair dissection by in vivo RNAi reveals dose-dependent modulators of somatic instability and proteome remodeling in Huntington's disease.bioRxiv202642395360PubTator, text miningPubMed
Computational Analysis of Differentially Expressed Genes in Arsenic-Induced Carcinogenesis and Their Effect on Human Repair Mechanisms.Environ Mol Mutagen202642219787PubTator, text miningPubMed
Clonal relationship in a rare pulmonary mixed tumor: shared ALK fusion in atypical carcinoid and adenocarcinoma-a case report.Transl Lung Cancer Res202642170278PubTator, text miningPubMed

1 to 10 of 1,886

See all 1,886 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5378

GET https://conductscience.org/api/genes/v1/5378/patents?page=2