Gene · 5378
PMS1: PMS1 homolog 1, mismatch repair system component
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PMS1: PMS1 homolog 1, mismatch repair system component. Genes, record 5378. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5378
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P54277 | PMS1 protein homolog 1 | 932 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents90
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 13408 | P54277 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 15302 | P54277 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 15302 | P54277 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 13408 | P54277 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7734 | P54277 | Espacenet |
| US 11504404 B2 | 2022-11-22 | 167 | P54277 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 64367 | P54277 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 167338 | P54277 | Espacenet |
| JP 2021169490 A | 2021-10-28 | 253 | P54277 | Espacenet |
| KR 1020210129616 A | 2021-10-28 | 39 | P54277 | Espacenet |
1 to 10 of 90
See all 90 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,260
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PMS1 papers | Newest fiscal year |
|---|---|---|---|
| R01GM050006 | Enzymology of Mismatch Repair in Yeast | 20 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 16 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 15 | 2025 |
| R01NS049206 | Huntington's Disease Repeat Instability and Pathogenesis | 8 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 6 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 6 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 6 | 2025 |
| R35GM134872 | Roles for Mismatch Repair Proteins in Maintaining Genome Stability | 5 | 2025 |
| ZIADK057808 | Understanding the mutational mechanism responsible for the Repeat Expansion Diseases | 5 | 2025 |
| ZIAES065089 | Studies Of DNA Mismatch Repair | 5 | 2025 |
1 to 10 of 1,260Source NIH's project files
See all 1,260 nih grantsPapers1,886
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Prevalence of pathogenic germline variants and indications for testing in a diverse community-based endometrial cancer cohort. | Gynecol Oncol | 2026 | 42822083 | PubTator, text mining | PubMed |
| Targeted quantification assays for DNA repair and handling proteins and interactions in Huntington's disease models. | bioRxiv | 2026 | 42619717 | PubTator, text mining | PubMed |
| Human PMS1-dependent non-canonical mismatch repair engages with MBD4 to repair methylated CpG deamination. | Nucleic Acids Res | 2026 | 42578366 | PubTator, text mining | PubMed |
| Potential advantage of clinical exome sequencing in BRCA1/2-negative families: a retrospective study of a cohort of 500 patients at a high-risk for hereditary cancers. | J Med Genet | 2026 | 42498519 | PubTator, text mining | PubMed |
| Transcriptomics Reveals L-Carnitine to Enhance Semen Quality in Malabari Bucks via Nutrigenomic Regulation of Key Biological Processes Associated With Male Fertility. | Reprod Domest Anim | 2026 | 42429318 | PubTator, text mining | PubMed |
| Identification and validation of biomarkers related to mismatch repair for prognosis prediction in glioma. | Front Immunol | 2026 | 42416056 | PubTator, text mining | PubMed |
| A retrospective study of differential prognostic factors in early-onset versus late-onset colorectal cancer: a comprehensive clinical and machine learning analysis. | PeerJ | 2026 | 42405254 | PubTator, text mining | PubMed |
| Mismatch repair dissection by in vivo RNAi reveals dose-dependent modulators of somatic instability and proteome remodeling in Huntington's disease. | bioRxiv | 2026 | 42395360 | PubTator, text mining | PubMed |
| Computational Analysis of Differentially Expressed Genes in Arsenic-Induced Carcinogenesis and Their Effect on Human Repair Mechanisms. | Environ Mol Mutagen | 2026 | 42219787 | PubTator, text mining | PubMed |
| Clonal relationship in a rare pulmonary mixed tumor: shared ALK fusion in atypical carcinoid and adenocarcinoma-a case report. | Transl Lung Cancer Res | 2026 | 42170278 | PubTator, text mining | PubMed |
1 to 10 of 1,886
See all 1,886 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5378
GET https://conductscience.org/api/genes/v1/5378/patents?page=2