Gene · 538
ATP7A: ATPase copper transporting alpha
12 sourcesgene-search-2026-11-11-0.2.0
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ConductScience Library. ATP7A: ATPase copper transporting alpha. Genes, record 538. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/538
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Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q04656 | Copper-transporting ATPase 1 | 1,500 | 22 | Ensembl, GeneID, HGNC |
Source UniProt
Patents19
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 334 | Q04656 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7002 | Q04656 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6877 | Q04656 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 532 | Q04656 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 532 | Q04656 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6877 | Q04656 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7002 | Q04656 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 7365 | Q04656 | Espacenet |
| JP 2023521663 A | 2023-05-25 | 333 | Q04656 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 7365 | Q04656 | Espacenet |
1 to 10 of 19
See all 19 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,344
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ATP7A papers | Newest fiscal year |
|---|---|---|---|
| R01DK071865 | Molecular Mechanisms of Active Copper Transport | 27 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 17 | 2025 |
| R01GM079465 | Chemical Probes to Study Copper Biology | 16 | 2025 |
| I01BX001232 | Cu importer CTR1 Cys189 oxidation in atherosclerosis | 10 | 2025 |
| R01EY015625 | Hermansky-Pudlak syndrome and melanosome formation | 9 | 2025 |
| I01CX000916 | Signaling Pathways and Therapeutic Targeting of Leukemic Cells | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| R01GM083144 | Characterization of mammalian COG complex-interacting Golgi trafficking machinery | 7 | 2025 |
| T32CA070085 | Training Program in Signal Transduction and Cancer | 6 | 2025 |
| R01DK117396 | Copper Homeostasis and Liver Function | 5 | 2025 |
1 to 10 of 1,344Source NIH's project files
See all 1,344 nih grantsPapers3,096
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Hijacking dead tumor cells for lung-targeted and gene-augmented cuproptosis therapy. | Biomaterials | 2027 | 42800426 | PubTator, text mining | PubMed |
| Mechanistic role of eIF4E in the hallmarks of cancer: A translational control perspective. | Crit Rev Oncol Hematol | 2026 | 42826912 | PubTator, text mining | PubMed |
| Roles of cuproptosis in central nervous system tumors: from molecular mechanisms to therapeutic prospects. | Front Cell Dev Biol | 2026 | 42812787 | PubTator, text mining | PubMed |
| Copper-Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF-α/ATP7A Axis. | Adv Sci (Weinh) | 2026 | 42801650 | PubTator, text mining | PubMed |
| Copper homeostasis in macrophages: regulatory mechanisms and immunological implications. | Front Chem | 2026 | 42769650 | PubTator, text mining | PubMed |
| Dysregulated KMT2D mutant targeting immunogenic rewiring to overcome epigenetic entropy promotes follicular lymphomagenesis. | Exp Hematol Oncol | 2026 | 42745287 | PubTator, text mining | PubMed |
| Investigation of the high-spin S2 states in photosystem II using Mn X-ray absorption spectroscopy with insights from XFEL crystallography. | Biochim Biophys Acta Bioenerg | 2026 | 42722122 | PubTator, text mining | PubMed |
| Copper, cuproptosis, and cancer: biology concepts of a novel cell death. | Apoptosis | 2026 | 42693224 | PubTator, text mining | PubMed |
| Plasma anti-ATP7A/ATP7B/COPT1 autoantibodies as potential biomarkers for breast cancer detection. | Clin Immunol | 2026 | 42660209 | PubTator, text mining | PubMed |
| Copper Metabolism-Related Cell Death in Kidney Diseases: Molecular Mechanisms, Disease-Specific Evidence, and Translational Implications. | Int J Mol Sci | 2026 | 42653078 | PubTator, text mining | PubMed |
1 to 10 of 3,096
See all 3,096 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
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GET https://conductscience.org/api/genes/v1/538/patents